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1.发明申请Magnetic resonance imaging using contrast agents bioactivated by enzymatic cleavage 审中-公开使用通过酶裂解生物活化的造影剂的磁共振成像公开(公告)号：US20050201943A1
公开(公告)日：2005-09-15
申请号：US11119630
申请日：2005-05-02
CPC分类号： A61K49/14 , A61K49/085
摘要： The present invention relates to contrast agents for diagnostic magnetic resonance imaging. In particular, this invention relates to novel compounds which exhibit surprisingly improved relaxivity due to improved binding of an amino acid targeting group within the molecules to proteins following specific cleavage of the agent by a peptidase. This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for contrast enhancement during magnetic resonance imaging.
摘要翻译： 本发明涉及用于诊断磁共振成像的造影剂。 特别地，本发明涉及新颖的化合物，其由于肽酶在特异性切割试剂后由于改善了分子内的氨基酸靶向基团与蛋白质的结合而出现惊人的改善的松弛度。 本发明还涉及包含这些化合物的药物组合物和在磁共振成像期间使用化合物和组合物进行对比度增强的方法。
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公开(公告)号：US20070111947A1
公开(公告)日：2007-05-17
申请号：US11581677
申请日：2006-10-16
申请人： Thomas McMurry , Andrew Kolodziej , Alan Carpenter , Simon Jones , Philip Graham , Richard Looby , Shrikumar Nair , Xifang Wang , Kirsten Overoye-Chan , John Barrett
发明人： Thomas McMurry , Andrew Kolodziej , Alan Carpenter , Simon Jones , Philip Graham , Richard Looby , Shrikumar Nair , Xifang Wang , Kirsten Overoye-Chan , John Barrett
CPC分类号： C07K7/08 , A61K38/00 , A61K47/62 , A61K47/64 , A61K47/6911 , A61K49/14 , A61K51/088 , C07K7/06
摘要： Fibrin targeted therapeutic agents for the treatment of thromboembolism, infection, and cancer are provided.
摘要翻译： 提供了用于治疗血栓栓塞，感染和癌症的纤维蛋白靶向治疗剂。
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公开(公告)号：US20070185311A1
公开(公告)日：2007-08-09
申请号：US11564648
申请日：2006-11-29
申请人： Zhaoda Zhang , John Amedio , Peter Caravan , Stephane Dumas , Andrew Kolodziej , Thomas McMurry
发明人： Zhaoda Zhang , John Amedio , Peter Caravan , Stephane Dumas , Andrew Kolodziej , Thomas McMurry
IPC分类号： C07K7/06
CPC分类号： C07K7/08 , A61K47/64 , A61K49/0039 , A61K49/0041 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/122 , A61K49/124 , A61K49/14 , A61K51/088 , C07K1/1077 , C07K7/06
摘要： Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
摘要翻译： 描述了肽和肽靶向多聚体造影剂，以及制造和使用造影剂的方法。
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公开(公告)号：US20060039861A1
公开(公告)日：2006-02-23
申请号：US11098665
申请日：2005-04-04
申请人： Zhaoda Zhang , John Amedio , Peter Caravan , Stephane Dumas , Andrew Kolodziej , Thomas McMurry
发明人： Zhaoda Zhang , John Amedio , Peter Caravan , Stephane Dumas , Andrew Kolodziej , Thomas McMurry
CPC分类号： C07K7/08 , A61K47/64 , A61K49/0039 , A61K49/0041 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/122 , A61K49/124 , A61K49/14 , A61K51/088 , C07K1/1077 , C07K7/06
摘要： Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
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公开(公告)号：US20050074411A1
公开(公告)日：2005-04-07
申请号：US10786791
申请日：2004-02-25
申请人： Zhaoda Zhang , John Amedio , Peter Caravan , Stephane Dumas , Andrew Kolodziej , Thomas McMurry
发明人： Zhaoda Zhang , John Amedio , Peter Caravan , Stephane Dumas , Andrew Kolodziej , Thomas McMurry
CPC分类号： C07K7/08 , A61K47/64 , A61K49/0039 , A61K49/0041 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/122 , A61K49/124 , A61K49/14 , A61K51/088 , C07K1/1077 , C07K7/06
摘要： Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
摘要翻译： 描述了肽和肽靶向多聚体造影剂，以及制造和使用造影剂的方法。
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公开(公告)号：US20070020184A1
公开(公告)日：2007-01-25
申请号：US11526302
申请日：2006-09-25
申请人： Thomas McMurry , Hironao Sijiki , Daniel Scott , Randall Lauffer
发明人： Thomas McMurry , Hironao Sijiki , Daniel Scott , Randall Lauffer
IPC分类号： A61K49/10 , C07F5/00 , C07D257/02
CPC分类号： A61K49/085 , A61B6/507 , A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , C07F9/091
摘要： The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
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公开(公告)号：US20070003479A1
公开(公告)日：2007-01-04
申请号：US11472842
申请日：2006-06-22
申请人： Thomas McMurry , Hironao Sijiki , Daniel Scott , Randall Lauffer
发明人： Thomas McMurry , Hironao Sijiki , Daniel Scott , Randall Lauffer
CPC分类号： A61K49/085 , A61B6/507 , A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , C07F9/091
摘要： The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
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公开(公告)号：US20070020185A1
公开(公告)日：2007-01-25
申请号：US11526312
申请日：2006-09-25
申请人： Thomas McMurry , Hironao Sijiki , Daniel Scott , Randall Lauffer
发明人： Thomas McMurry , Hironao Sijiki , Daniel Scott , Randall Lauffer
CPC分类号： A61K49/085 , A61B6/507 , A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , C07F9/091
摘要： The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
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公开(公告)号：US20060275216A1
公开(公告)日：2006-12-07
申请号：US11504851
申请日：2006-08-16
申请人： Randall Lauffer , Thomas McMurry , Stephen Dunham , Daniel Scott , David Parmelee , Stephane Dumas
发明人： Randall Lauffer , Thomas McMurry , Stephen Dunham , Daniel Scott , David Parmelee , Stephane Dumas
IPC分类号： A61K49/10
CPC分类号： A61K49/14 , A61K49/0002 , A61K49/0017 , A61K49/0019 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106
摘要： The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
摘要翻译： 本发明涉及用于磁共振成像和光学成像的改进诊断剂。 特别地，本发明涉及允许灵敏检测组织内特定生物活性的MRI和光学成像剂。 这些试剂是在特异性生物活性存在下在体内生物活化的前体药物对比剂。 本发明还涉及包含这些试剂的药物组合物以及使用包含该试剂的试剂和组合物的方法。
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公开(公告)号：US20060148683A1
公开(公告)日：2006-07-06
申请号：US10492108
申请日：2002-10-16
申请人： Thomas McMurry , Robert Weisskoff
发明人： Thomas McMurry , Robert Weisskoff
CPC分类号： A61K49/0056 , A61K38/08 , A61K38/12 , A61K38/49 , A61K49/0039 , A61K49/0041 , A61K49/0043
摘要： Optical agents that contain a fibrin binding moiety covalently linked to an optical dye are described, as well as methods of treating intravascular lesions in a patient using such optical agents.
摘要翻译： 描述了包含与光学染料共价连接的纤维蛋白结合部分的光学剂，以及使用这种光学剂治疗患者的血管内病变的方法。
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