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1.发明申请Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US20090311283A1
公开(公告)日：2009-12-17
申请号：US11976998
申请日：2007-10-30
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
CPC分类号： C07K14/005 , A61K31/7088 , A61K2039/53 , A61K2039/55516 , A61K2039/6031 , A61K2039/70 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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2.发明授权Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 失效使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US06689363B1
公开(公告)日：2004-02-10
申请号：US09239043
申请日：1999-01-27
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , A61K2039/70 , C07K14/005 , C07K14/33 , C07K14/4746 , C07K14/705 , C07K14/70539 , C07K14/82 , C12N2730/10122 , C12N2740/16022 , C12N2760/16122 , C12N2770/24222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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3.发明申请Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US20110097352A9
公开(公告)日：2011-04-28
申请号：US11976998
申请日：2007-10-30
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
CPC分类号： C07K14/005 , A61K31/7088 , A61K2039/53 , A61K2039/55516 , A61K2039/6031 , A61K2039/70 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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公开(公告)号：US06419931B1
公开(公告)日：2002-07-16
申请号：US08197484
申请日：1994-02-16
IPC分类号： A61K39295
CPC分类号： C07K14/005 , A61K39/00 , C07K14/33 , C07K14/705 , C12N2710/20022 , C12N2730/10122 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2760/16122 , C12N2770/24222
摘要： Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions, of CTL-inducing peptide and an adjuvant or a lipidated peptide which induces a helper T cell (HTL) response stimulate the antigen specific CTL response. Among the viral antigens to which the CTL responses are effectively induced in humans are those of hepatitis B. The CTL response may be optimized by a regimen of two or more booster administrations. Cocktails of two or more CTL inducing peptides are employed to optimize epitope and/or MHC class I restricted coverage.
摘要翻译： 细胞毒性T淋巴细胞反应有效地诱导到感兴趣的抗原，特别是病毒，细菌，寄生虫和肿瘤抗原。 诱导CTL诱导肽的组合物，诱导辅助性T细胞（HTL）应答的佐剂或脂质化肽的组合物刺激抗原特异性CTL应答。 在人类中有效诱导CTL反应的病毒抗原是乙型肝炎的病毒抗原。可以通过两次或更多次加强给药的方案来优化CTL应答。 使用两种或更多种CTL诱导肽的鸡尾酒优化表位和/或MHC I类限制覆盖。
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公开(公告)号：US06322789B1
公开(公告)日：2001-11-27
申请号：US08464496
申请日：1995-06-05
IPC分类号： A61K3929
CPC分类号： C07K14/005 , A61K39/00 , C12N2730/10122
摘要： Cytotoxic T lymphocyte-stimulating peptides induce HLA-restricted responses to hepatitis B virus antigens. The peptides, derived from CTL epitopic regions of both HBV surface and nucleocapsid antigens, are particularly useful in the treatment and prevention of HBV infection, including the treatment of chronically infected HBV carriers. The peptides can be formulated as HBV vaccines and pharmaceutical compositions, such as lipid-containing compositions for enhancing the HLA-restricted CTL responses. The peptides are also useful in diagnostic methods, such as predicting which HBV-infected individuals are prone to developing chronic infection.
摘要翻译： 细胞毒性T淋巴细胞刺激肽诱导对乙型肝炎病毒抗原的HLA限制性应答。 源自HBV表面和核衣壳抗原的CTL表位区的肽特别可用于治疗和预防HBV感染，包括治疗慢性感染的HBV携带者。 肽可以配制成HBV疫苗和药物组合物，例如用于增强HLA限制性CTL应答的含脂质组合物。 这些肽也可用于诊断方法，例如预测哪些HBV感染个体易发展为慢性感染。
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公开(公告)号：US20080160089A1
公开(公告)日：2008-07-03
申请号：US11701229
申请日：2007-01-31
CPC分类号： A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/385 , A61K47/59 , A61K47/593 , A61K47/595 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/585 , A61K2039/6093 , C08G18/4266 , C08G71/02 , C08G71/04 , C08G2230/00 , C12N2710/14143 , C12N2710/20034 , C12N2740/16134 , C12N2760/16134
摘要： The present invention provides synthetic vaccines against a variety of pathogenic organisms and tumor cells in humans and other mammals based on biodegradable polymers containing polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) and immunostimulatory adjuvants. The vaccines can be formulated as a liquid dispersion of polymer particles or molecules in which are dispersed an immunostimulatory adjuvant, such as a TLR agonist, and whole protein or peptidic antigens containing MHC class I or class II epitopes derived from organism or tumor cell proteins. Methods of inducing an immune response via intracellular mechanisms to the pathogenic organism or tumor cells specific for the antigen in the invention compositions are also included.
摘要翻译： 本发明基于含有聚酯酰胺（PEA），聚酯氨基甲酸酯（PEUR）和聚酯尿素（PEU）和免疫刺激性佐剂的生物可降解聚合物，提供针对人类和其它哺乳动物中各种致病生物体和肿瘤细胞的合成疫苗。 疫苗可以配制成聚合物颗粒或分子的液体分散体，其中分散有免疫刺激佐剂，例如TLR激动剂，以及含有衍生自生物体或肿瘤细胞蛋白的MHC I类或II类表位的全蛋白或肽抗原。 还包括通过细胞内机制诱导本发明组合物中针对抗原特异性的致病生物体或肿瘤细胞的免疫应答的方法。
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