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1.发明授权公开(公告)号：US08524906B2
公开(公告)日：2013-09-03
申请号：US13211502
申请日：2011-08-17
申请人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
发明人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
IPC分类号： A61K31/4365 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kgamma的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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2.发明申请公开(公告)号：US20120039849A1
公开(公告)日：2012-02-16
申请号：US13211502
申请日：2011-08-17
申请人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
发明人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
IPC分类号： A61K31/437 , A61K31/497 , A61P25/00 , A61P29/00 , C12N9/99 , A61P37/06 , A61K38/21 , A61K38/07 , A61K39/395 , C07D471/04 , A61P37/02
CPC分类号： C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07279469B2
公开(公告)日：2007-10-09
申请号：US10715111
申请日：2003-11-17
申请人： Albert C. Pierce , Michael Amost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
发明人： Albert C. Pierce , Michael Amost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
IPC分类号： A61K31/541 , A61K31/55 , A61K31/4196 , A61K31/5377 , C07D417/02 , C07D413/02
CPC分类号： C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07902239B2
公开(公告)日：2011-03-08
申请号：US11774702
申请日：2007-07-09
申请人： Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
发明人： Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
IPC分类号： A61K31/541 , A61K31/55 , A61K31/4196 , A61K31/5377
CPC分类号： C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08686143B2
公开(公告)日：2014-04-01
申请号：US13280670
申请日：2011-10-25
申请人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
发明人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20120157429A1
公开(公告)日：2012-06-21
申请号：US13280670
申请日：2011-10-25
申请人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
发明人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
IPC分类号： A61K31/506 , C07D403/04 , C07D413/14 , A61K31/5377 , C07D403/10 , C12N9/99 , A61P9/00 , A61P25/28 , A61P37/00 , A61P37/06 , A61P29/00 , C07D401/04 , A61P35/00
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20080014189A1
公开(公告)日：2008-01-17
申请号：US11774702
申请日：2007-07-09
申请人： Albert Pierce , Michael Arnost , Robert Davies , Cornelia Forster , Vincent Galullo , Ronald Gray , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco Salituro , Jian Wang
发明人： Albert Pierce , Michael Arnost , Robert Davies , Cornelia Forster , Vincent Galullo , Ronald Gray , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco Salituro , Jian Wang
IPC分类号： A61K38/50 , A61K31/4196 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/47 , A61K31/505 , A61P19/00 , A61P3/00 , C07D239/28 , C07D239/24 , A61P9/00 , A61P37/08 , A61P35/00 , A61P25/28 , A61P11/06 , A61K31/519 , A61K31/5377 , A61K31/555 , A61K31/573 , A61K31/675
CPC分类号： C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20100160287A1
公开(公告)日：2010-06-24
申请号：US12564156
申请日：2009-09-22
申请人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
发明人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
IPC分类号： A61K31/506 , C07D401/04 , C07D403/04 , C07D417/10 , C07D403/10 , C07D405/10 , A61P35/00 , A61P9/00 , A61P19/08 , A61P37/06 , A61P29/00 , A61P37/00 , A61P31/12 , C12N5/00
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08232406B2
公开(公告)日：2012-07-31
申请号：US12942395
申请日：2010-11-09
申请人： David J. Lauffer , Robert J. Davies , Dean Stamos , Alexander Aronov , David D. Deininger , Ronald Grey, Jr. , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Kira McGinty
发明人： David J. Lauffer , Robert J. Davies , Dean Stamos , Alexander Aronov , David D. Deininger , Ronald Grey, Jr. , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Kira McGinty
IPC分类号： A61K31/4439
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20110059936A1
公开(公告)日：2011-03-10
申请号：US12942395
申请日：2010-11-09
申请人： David J. Lauffer , Robert J. Davies , Dean Stamos , Alexander Aronov , David D. Deininger , Ronald Grey, JR. , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Kira McGinty
发明人： David J. Lauffer , Robert J. Davies , Dean Stamos , Alexander Aronov , David D. Deininger , Ronald Grey, JR. , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Kira McGinty
IPC分类号： A61K31/497 , A61K31/5377 , A61K31/496 , A61K31/444 , A61K31/4439 , A61K31/501 , A61K31/537 , A61P35/00 , A61P35/04
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
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