摘要:
Disclosed are compositions and methods for preventing or reducing harm resulting from pathogen infection. For example, disclosed are peptides that inhibit the processing of toxins normally cleaved by proprotein convertase enzymes.
摘要:
Disclosed are compositions and methods for preventing or reducing harm resulting from pathogen infection. For example, disclosed are peptides that inhibit the processing of toxins normally cleaved by proprotein convertase enzymes.
摘要:
One aspect of the present invention can include an operating lever of a vehicular seat provided at a front face, an upper face, or a back face of a seat, including a seat cushion and a seat back, and a first lever and a second lever. The first lever and the second lever are axially supported pivotably to each other on one end sides in length directions. An other end side in the length direction of the first lever is axially supported pivotably to the seat and is connected to a lock mechanism capable of changing a state of an attitude of the seat. The other end side in the length direction of the second lever is formed as an operating portion. The attitude of the seat can be operated while bending the first lever in two stages around axial shafts on sides of both ends in the length direction of the first lever by operating an operating portion of the second lever in a direction of being remote from the seat.
摘要:
A file operations engine is provided that manages many user interactions with their files via a computer system. The operation engine may provide a user with the option to keep both files that have a file name conflict. It may further permit the user to rename a file involved with a file name conflict. The operations engine may also automatically rename one of the files of a file name conflict by appending a character to a root of the filename. The character may include the lowest integer available for the root in a destination for the files. The operations engine may provide the option to keep both files as part of a pre-calculation of potential errors for a requested operation. The operations engine may place file name conflicts in an error queue and permit the user to select an option to keep both files after the conflict is encountered.
摘要:
To date, those skilled in the art have never considered that cultured plant cells respond to gibberellins. However, to comprehensively and conveniently identify and isolate gibberellin responsive genes, cultured cells, which are uniform and easy to handle, are appropriate. Considering the advantages of cultured cells, the present inventors developed methods for identifying and isolating gibberellin responsive genes using cultured cells. After pre-culturing cells in an auxin-free medium, they examined whether or not changes in gene expression could be detected. As a result, it was surprisingly revealed that changes in the expression of some genes could be detected after gibberellin treatment.
摘要:
Provided is bone or bone tissue supplemented with at least a therapeutically useful compound, wherein said compound is concentrated within the bone matrix. Also provided is a method of supplementing bone and bone tissue.
摘要:
The present invention relates to the cloning of human pro-protein converting enzyme 5 (PC5) CDNA isolated from human adrenal gland messenger RNA. Additionally, this invention relates to a method for reducing restenosis occurring at an injured vascular site comprising delivering to the injured site an antisense nucleic acid to suppress the expression of human PC5.
摘要:
This invention relates to a novel and seventh member of the subtilisin-kexin family isolated from rat, which has been named rPC7. The rat spleen cDNA has been totally sequenced. A shorter DNA sequence has been obtained for human, which corresponds to a portion of the catalytic region of a human pro-hormone convertase corresponding to the rat pro-hormone convertase. PC7 clearly distinguishes from the other mammalian members of the subtilisin-kexin family. Its tissue distribution is ubiquitous, but its presence is particularly remarkable in lymphoid tissues. It is present in LoVo cells that are able to cleave the HIV gp160 protein into active gp120/gp41 proteins and that are deficient in other effective pro-hormone convertases known up to date. Therefore, it is proposed that PC7 is a good candidate as a maturation enzyme responsible for the conversion of HIV gp160 protein in target CD.sup.+4 cells.
摘要:
It is provided PACE4 inhibitors and their uses for treating infection, cancer. Particularly, it is provided a method or use for the treatment of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the PACE4 inhibitors or the composition disclosed.
摘要:
Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation, reducing tumor growth, reducing metastasis formation, preventing and/or treating cancer. Also provided are methods for lowering PACE4 activity, reducing the proliferation of a cell, reducing tumor growth and/or treating and preventing cancer. Methods for screening PACE4 inhibitors and cell proliferation inhibitors are further provided.