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公开(公告)号：US4335108A
公开(公告)日：1982-06-15
申请号：US180682
申请日：1980-08-25
摘要： Disclosed and claimed is an improved fermentation process for preparing the known antibiotic U-43,120, herein referred to as paulomycin. Also disclosed and claimed are the novel and useful antibiotics paulomycin A and paulomycin B.
摘要翻译： 公开和要求保护的是用于制备已知抗生素U-43,120（在本文中称为保罗霉素）的改进的发酵方法。 还公开并要求保护的是新型有用的抗生素保罗霉素A和保宝霉素B.
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公开(公告)号：US4505895A
公开(公告)日：1985-03-19
申请号：US480604
申请日：1983-03-30
CPC分类号： C12P1/06
摘要： Novel and useful antibiotics designated 273a.sub.1.spsb..alpha. and 273a.sub.1.spsb..beta. can be produced in a fermentation using Streptomyces paulus, strain 273, NRRL 12251. These antibiotics are active against various Gram-positive bacteria. Also, these antibiotics are, advantageously, soluble in aqueous solutions.
摘要翻译： 在使用链霉菌（Streptomyces paulus），菌株273，NRRL 12251的发酵中可以产生名为273a1α和273a1β的新型和有用的抗生素。这些抗生素对各种革兰氏阳性细菌具有活性。 而且，这些抗生素有利地可溶于水溶液。
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公开(公告)号：US4430495A
公开(公告)日：1984-02-07
申请号：US419244
申请日：1982-09-17
摘要： Novel and useful ribonucleotides of analogs of the well known antibiotics lincomycin and clindamycin. These ribonucleotides are unexpectedly highly active against Streptococcus hemolyticus and Staphylococcus aureus in vivo. These ribonucleotides are prepared by using resting cell or cell-free extracts of Streptomyces rochei, NRRL 3533, or cell-free extracts of Streptomyces coelicolor, NRRL 3532.
摘要翻译： 新型和有用的核糖核苷酸类似物的众所周知的抗生素林可霉素和克林霉素。 这些核糖核苷酸在体内对溶血链球菌和金黄色葡萄球菌意外高度活跃。 这些核糖核苷酸是通过使用链霉菌（Streptomyces rochei），NRRL 3533的静止细胞或无细胞提取物或无链球菌链霉菌NRRL 3532的提取物来制备的。
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4.发明授权Process for producing 10.dbd.dihydrosteffimycin and 10.dbd.dihydrosteffimycin B and microorganisms for producing same 失效制备10 =二氢酪蛋白霉素和10 =二氢去氧霉素B的方法及其生产微生物
公开(公告)号：US4264726A
公开(公告)日：1981-04-28
申请号：US129532
申请日：1980-03-12
IPC分类号： C07H15/252 , C12P19/56 , C12P19/46 , C12N1/14
CPC分类号： C12R1/045 , C07H15/252 , C12P19/56 , Y10S435/827 , Y10S435/911
摘要： Antibiotics 10-dihydrosteffimycin (U-58,875), and 10-dihydrosteffimycin B (U-58,874) are produced by carbon 10 ketonic carbonyl reduction in fermentation processes using the known antibiotics steffimycin and steffimycin B, respectively, as starting materials. These novel antibiotics are active against various microorganisms, for example, Bacillus subtilis, Bacillus cereus, Sarcina lutea, Streptococcus pyogenes, and Mycobacterium avium. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.
摘要翻译： 作为起始原料，使用已知的抗生素Steffimycin和steffimycin B作为起始原料，通过发酵过程中的碳10酮羰基还原制备了抗生素10-二氢去氧霉素（U-58,875）和10-二氢酪蛋白霉素B（U-58,874）。 这些新型抗生素对各种微生物具有活性，例如枯草芽孢杆菌，蜡状芽孢杆菌，黄连，链球菌和鸟分枝杆菌。 因此，这些抗生素可用于抑制各种环境中上述微生物的生长。
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公开(公告)号：US4116769A
公开(公告)日：1978-09-26
申请号：US851861
申请日：1977-11-16
IPC分类号： C12D9/20
CPC分类号： C12P29/00 , Y10S435/803 , Y10S435/822 , Y10S435/886
摘要： Bioconversion of the antibiotic steffimycinone to the antibiotic steffimycinol. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes. Steffimycinol is converted to 7-deoxysteffimycinol by a microaerophilic Aeromonas hydrophila fermentation. 7-Deoxysteffimycinol is active against Sarcina lutea, Bacillus cereus, and B. subtilis. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.
摘要翻译： 将抗生素Steffimycinone生物转化为抗生素steffimycinol。 Steffimycinol对各种微生物有活性，例如枯草芽孢杆菌，鸟分枝杆菌和化脓性链球菌。 通过微嗜酸气单胞菌嗜水气单胞菌发酵将Steffimycinol转化为7-脱氧硫嘧啶。 7-脱氧半胱氨酰霉素对黄体，蜡状芽孢杆菌和枯草芽孢杆菌具有活性。 因此，这些抗生素可用于抑制各种环境中上述微生物的生长。
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公开(公告)号：US4106994A
公开(公告)日：1978-08-15
申请号：US851866
申请日：1977-11-16
IPC分类号： C12D9/14
CPC分类号： C12P29/00 , Y10S435/803 , Y10S435/822 , Y10S435/886
摘要： Bioconversion of the antibiotic steffimycinone to the antibiotic steffimycinol. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes. Steffimycinol is converted to 7-deoxysteffimycinol by a microaerophilic Aeromonas hydrophila fermentation. 7-Deoxysteffimycinol is active against Sarcina lutea, Bacillus cereus, and B. subtilis. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.
摘要翻译： 将抗生素Steffimycinone生物转化为抗生素steffimycinol。 Steffimycinol对各种微生物有活性，例如枯草芽孢杆菌，鸟分枝杆菌和化脓性链球菌。 通过微嗜性嗜水气单胞菌嗜水气单胞菌发酵将Steffimycinol转化为7-脱氧硫嘧啶醇。 7-脱氧半胱氨酰霉素对黄体，蜡状芽孢杆菌和枯草芽孢杆菌具有活性。 因此，这些抗生素可用于抑制各种环境中上述微生物的生长。
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公开(公告)号：US4077844A
公开(公告)日：1978-03-07
申请号：US782621
申请日：1977-03-30
IPC分类号： C12D9/18
CPC分类号： C12P29/00 , Y10S435/803 , Y10S435/822 , Y10S435/886
摘要： Bioconversion of the antibiotic steffimycinone to the antibiotic steffimycinol. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes. Steffimycinol is converted to 7-deoxysteffimycinol by a microaerophilic Aeromonas hydrophila fermentation. 7-Deoxysteffimycinol is active against Sarcina lutea, Bacillus cereus, and B. subtilis. Thus, there antibiotics can be used to inhibit the growth of the above microorganisms in various environments.
摘要翻译： 将抗生素Steffimycinone生物转化为抗生素steffimycinol。 Steffimycinol对各种微生物有活性，例如枯草芽孢杆菌，鸟分枝杆菌和化脓性链球菌。 通过微嗜酸气单胞菌嗜水气单胞菌发酵将Steffimycinol转化为7-脱氧硫嘧啶。 7-脱氧半胱氨酰霉素对黄体，蜡状芽孢杆菌和枯草芽孢杆菌具有活性。 因此，可以使用抗生素来抑制各种环境中的上述微生物的生长。
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8.发明授权Dioxapyrrolomycin as an antiparasitic agent and compositions useful therefor 失效二恶吡咯霉素作为抗寄生虫剂及其有用的组合物
公开(公告)号：US5643940A
公开(公告)日：1997-07-01
申请号：US432374
申请日：1995-05-01
IPC分类号： A61K31/4025 , A61K31/40
CPC分类号： A61K31/4025
摘要： This invention concerns a method for killing internal parasites, especially nematodes, trematodes and cestodes affecting warm blooded animals such as sheep, cattle, swine, goats, dogs, cats, horses and humans as well as poultry by administering an effective amount of dioxapyrrolomycin of the formula I. Anthelmintic compositions of dioxapyrrolomycin and an improvement in the process of preparation of dioxapyrrolomycin are also provided. ##STR1##
摘要翻译： 本发明涉及一种通过施用有效量的二氧代吡咯并霉素来杀死影响温血动物如羊，牛，猪，山羊，狗，猫，马和人以及家禽的内部寄生虫，特别是线虫，吸虫和绦虫的方法。 还提供了二恶二吡咯霉素的驱虫剂组合物和二氧嘧啶霉素制备方法的改进。
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公开(公告)号：US4209611A
公开(公告)日：1980-06-24
申请号：US27878
申请日：1979-04-06
IPC分类号： C07H15/252 , C12P19/56 , C07H15/24
CPC分类号： C07H15/252 , C12P19/56 , C12R1/045
摘要： Antibiotics 10-dihydrosteffimycin (U-58,875), and 10-dihydrosteffimycin B (U-58,874) are produced by carbon 10 ketonic carbonyl reduction in fermentation processes using the known antibiotics steffimycin and steffimycin B, respectively, as starting materials. These novel antibiotics are active against various microorganisms, for example, Bacillus subtilis, Bacillus cereus, Sarcina lutea, Streptococcus pyogenes, and Mycobacterium avium. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.
摘要翻译： 作为起始原料，使用已知的抗生素Steffimycin和steffimycin B作为起始原料，通过发酵过程中的碳10酮羰基还原制备了抗生素10-二氢去氧霉素（U-58,875）和10-二氢酪蛋白霉素B（U-58,874）。 这些新型抗生素对各种微生物具有活性，例如枯草芽孢杆菌，蜡状芽孢杆菌，黄连，链球菌和鸟分枝杆菌。 因此，这些抗生素可用于抑制各种环境中上述微生物的生长。
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