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公开(公告)号：US06770095B2
公开(公告)日：2004-08-03
申请号：US10174457
申请日：2002-06-18
IPC分类号： A61F244
CPC分类号： A61F2/4425 , A61F2/30767 , A61F2002/30092 , A61F2002/30113 , A61F2002/30125 , A61F2002/30133 , A61F2002/30153 , A61F2002/30154 , A61F2002/30158 , A61F2002/30187 , A61F2002/30299 , A61F2002/30364 , A61F2002/30369 , A61F2002/30372 , A61F2002/3038 , A61F2002/30405 , A61F2002/30462 , A61F2002/30464 , A61F2002/305 , A61F2002/30528 , A61F2002/30563 , A61F2002/30578 , A61F2002/30649 , A61F2002/30662 , A61F2002/30843 , A61F2002/443 , A61F2210/0014 , A61F2220/0025 , A61F2220/0033 , A61F2220/0075 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0019 , A61F2230/0021 , A61F2230/0026 , A61F2230/0034 , A61F2230/0093 , A61F2310/00029 , A61F2310/0058 , A61F2310/0088
摘要： This invention relates to an intervertebral motion disc having an articulation interface and a locking interface.
摘要翻译： 本发明涉及具有关节界面和锁定界面的椎间盘运动盘。
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2.发明申请Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号：US20050025765A1
公开(公告)日：2005-02-03
申请号：US10630227
申请日：2003-07-30
申请人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Martin Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
发明人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Martin Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K31/198 , A61K31/436 , A61K38/18 , A61K38/30 , A61P19/02 , A61K39/395 , A61K38/17
CPC分类号： A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要： The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译： 本发明涉及向患病关节中透射施用高特异性拮抗剂，所述高特异性拮抗剂选自：i）促炎白细胞介素的抑制剂; ii）TNF-α合成抑制剂; iii）膜结合TNF-α的抑制剂; iv）TNF-α的天然受体的抑制剂; v）NO合酶抑制剂，vi）PLA2酶抑制剂; vii）抗增殖剂; viii）抗氧化剂; ix）选自EPO模拟肽，EPO模拟物，IGF-I，IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂，和x）MMP的抑制剂; 和xi）p38激酶的抑制剂。
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3.发明授权公开(公告)号：US08895540B2
公开(公告)日：2014-11-25
申请号：US10723250
申请日：2003-11-26
申请人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas G. Ferro , Vivek N. Shenoy , Alonzo D. Cook , Scott Bruder
发明人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas G. Ferro , Vivek N. Shenoy , Alonzo D. Cook , Scott Bruder
IPC分类号： A01N45/00 , A61K45/06 , A61K33/42 , A61K38/39 , A61K31/565 , A61K39/395 , A61K38/18 , A61K31/566 , A61B17/34 , A61K9/00 , A61M5/145 , A61M5/142 , A61F2/30 , A61F2/28
CPC分类号： A61K33/42 , A61B17/3472 , A61F2002/2817 , A61F2002/30677 , A61K9/0004 , A61K31/565 , A61K31/566 , A61K38/1825 , A61K38/1875 , A61K38/39 , A61K39/395 , A61K45/06 , A61M5/14276 , A61M2005/14513 , A61K2300/00
摘要： This invention relates to local administration of a bone-forming agent and at least one anti-resorptive agent to treat osteoporosis and related disorders.
摘要翻译： 本发明涉及局部施用骨形成剂和至少一种抗再吸收剂来治疗骨质疏松症和相关疾病。
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公开(公告)号：US08273347B2
公开(公告)日：2012-09-25
申请号：US10714594
申请日：2003-11-14
CPC分类号： A61K35/19 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/1841 , A61K2300/00
摘要： The present invention relates to administering autologous uncultured cells into a diseased intervertebral disc.
摘要翻译： 本发明涉及将自体未培养的细胞施用于患病的椎间盘。
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5.发明授权Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号：US08361467B2
公开(公告)日：2013-01-29
申请号：US10630227
申请日：2003-07-30
申请人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
发明人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K39/395 , A61K39/00 , A61K38/18
CPC分类号： A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要： The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译： 本发明涉及向患病关节中透射施用高特异性拮抗剂，所述高特异性拮抗剂选自：i）促炎白细胞介素的抑制剂; ii）TNF-α合成抑制剂; iii）膜结合TNF-α的抑制剂; iv）TNF-α的天然受体的抑制剂; v）NO合酶抑制剂，vi）PLA2酶抑制剂; vii）抗增殖剂; viii）抗氧化剂; ix）选自EPO模拟肽，EPO模拟物，IGF-I，IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂，和x）MMP的抑制剂; 和xi）p38激酶的抑制剂。
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公开(公告)号：US08333960B2
公开(公告)日：2012-12-18
申请号：US12291016
申请日：2008-10-31
CPC分类号： A61K35/19 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/1841 , A61K2300/00
摘要： The present invention relates to administering autologous uncultured cells into a diseased intervertebral disc.
摘要翻译： 本发明涉及将自体未培养的细胞施用于患病的椎间盘。
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7.发明申请公开(公告)号：US20050112091A1
公开(公告)日：2005-05-26
申请号：US10723250
申请日：2003-11-26
申请人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas Ferro , Vivek Shenoy , Alonzo Cook , Scott Bruder
发明人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas Ferro , Vivek Shenoy , Alonzo Cook , Scott Bruder
IPC分类号： A61B17/34 , A61F2/28 , A61F2/30 , A61K38/19 , A61K38/20 , A61K39/395 , A61K45/06 , A61K31/56
CPC分类号： A61K33/42 , A61B17/3472 , A61F2002/2817 , A61F2002/30677 , A61K9/0004 , A61K31/565 , A61K31/566 , A61K38/1825 , A61K38/1875 , A61K38/39 , A61K39/395 , A61K45/06 , A61M5/14276 , A61M2005/14513 , A61K2300/00
摘要： This invention relates to local administration of a bone-forming agent and at least one anti-resorptive agent to treat osteoporosis and related disorders.
摘要翻译： 本发明涉及局部施用骨形成剂和至少一种抗再吸收剂来治疗骨质疏松症和相关疾病。
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公开(公告)号：US20090068270A1
公开(公告)日：2009-03-12
申请号：US12291016
申请日：2008-10-31
CPC分类号： A61K35/19 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/1841 , A61K2300/00
摘要： The present invention relates to administering autologous uncultured cells into a diseased intervertebral disc.
摘要翻译： 本发明涉及将自体未培养的细胞施用于患病的椎间盘。
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公开(公告)号：US20050038001A1
公开(公告)日：2005-02-17
申请号：US10640412
申请日：2003-08-13
申请人： Mohamed Attawia , Thomas DiMauro , Hassan Serhan , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
发明人： Mohamed Attawia , Thomas DiMauro , Hassan Serhan , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K31/65
CPC分类号： A61K31/65 , A61K38/20 , A61K45/06 , A61K2300/00
摘要： The present invention relates to injecting a cycline compound into a diseased intervertebral disc.
摘要翻译： 本发明涉及将环状化合物注射到患病的椎间盘中。
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