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1.发明授权Systems and methods for controlling light phase difference in interferometric waveguides at near field transducers 有权用于控制近场换能器的干涉波导中的光相位差的系统和方法公开(公告)号：US08675455B1
公开(公告)日：2014-03-18
申请号：US13399325
申请日：2012-02-17
CPC分类号： G11B5/6088 , G11B5/105 , G11B5/3133 , G11B5/314 , G11B2005/0021
摘要： Systems and methods for controlling light phase difference in interferometric waveguides at near field transducers by selectively heating the light source are provided. One such system for controlling light phase at the NFT of an interferometric waveguide includes a laser, a heater configured to heat the laser, a splitter configured to receive light from the laser and to split the light into a first waveguide arm and a second waveguide arm, the first waveguide arm and the second waveguide arm converging at a junction about opposite the splitter, and the NFT proximate the junction and configured to receive the light, where the first waveguide arm is longer than the second waveguide arm by a preselected distance, and where the heater is configured to generate and maintain a preselected phase difference in the light arriving at the NFT via the first waveguide arm and the second waveguide arm.
摘要翻译： 提供了通过选择性加热光源来控制近场换能器的干涉波导中的光相位差的系统和方法。 一种用于在干涉波导的NFT处控制光相的这种系统包括激光器，被配置为加热激光器的加热器，被配置为接收来自激光器的光并将光分成第一波导臂和第二波导臂 ，所述第一波导臂和所述第二波导臂在与所述分路器相对的接合处会聚，并且所述NFT邻近所述接合处并且被配置为接收所述光，其中所述第一波导臂比所述第二波导臂长一预定距离，以及 其中所述加热器被配置为在经由所述第一波导臂和所述第二波导臂到达所述NFT的光中产生并保持预选的相位差。
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公开(公告)号：US20110075288A1
公开(公告)日：2011-03-31
申请号：US12995152
申请日：2009-05-29
申请人： Alexander Krichevsky , Sakhrat Khizroev , Ilya Isaakovich Dumer , Andrey Alekseyevich Lavrenov , Nissim Amos
发明人： Alexander Krichevsky , Sakhrat Khizroev , Ilya Isaakovich Dumer , Andrey Alekseyevich Lavrenov , Nissim Amos
CPC分类号： G11B5/66 , B82Y10/00 , G11B5/02 , G11B5/59688 , G11B5/667 , G11B5/7325 , G11B5/7379 , G11B5/743 , G11B5/746 , G11B5/82 , G11B5/855 , G11B2005/0005
摘要： A novel magnetic recording medium is disclosed in which a plurality of magnetic data recording layers and navigation layers are separate from one another. By decoupling the navigation and data layers, data may be written to data layers without the need to align the written data along servo tracks. Thus, the data layers may be configured for high recording density. Beneficially, imperfections within the magnetic data layers may also be compensated for by the use of adaptive error correction schemes which vary the encoding/decoding of data during writing/reading based upon the local quality of the recording media.
摘要翻译： 公开了一种新的磁记录介质，其中多个磁数据记录层和导航层彼此分开。 通过解耦导航和数据层，可以将数据写入数据层，而不需要沿着伺服磁道对准写入的数据。 因此，可以将数据层配置为高记录密度。 有利的是，磁数据层中的缺陷也可以通过使用自适应纠错方案进行补偿，所述自适应纠错方案基于记录介质的本地质量在写入/读取期间改变数据的编码/解码。
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3.发明授权Bioluminescent plants comprising bacterial LUX operon and methods of making same 有权包含细菌LUX操纵子的生物发光植物及其制备方法公开(公告)号：US09506075B2
公开(公告)日：2016-11-29
申请号：US12670340
申请日：2008-07-31
申请人： Alexander Krichevsky
发明人： Alexander Krichevsky
IPC分类号： C12N15/82
CPC分类号： C12N15/8214 , C12N15/8212 , C12N15/8213 , C12N15/8242 , C12N15/825
摘要： In one aspect, the invention relates to a transgenic bioluminescent plant including an expressible heterologous nucleotide sequence comprising a bacterial LUX operon, which includes LUX A, LUX B, LUX C, LUX D, LUX E, and LUX G genes, wherein the heterologous nucleotide sequence is expressed to render the plant bioluminescent.
摘要翻译： 一方面，本发明涉及一种转基因生物发光植物，其包含包含LUX A，LUX B，LUX C，LUX D，LUX E和LUX G基因的细菌LUX操纵子的可表达异源核苷酸序列，其中所述异源核苷酸 表达序列以使植物生物发光。
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4.发明申请AUTOLUMINESCENT PLANTS INCLUDING THE BACTERIAL LUX OPERON AND METHODS OF MAKING SAME 审中-公开包括细菌LUX操作的自动植物植物及其制造方法公开(公告)号：US20130074221A1
公开(公告)日：2013-03-21
申请号：US13580922
申请日：2010-02-25
申请人： Alexander Krichevsky
发明人： Alexander Krichevsky
IPC分类号： C12N15/82
CPC分类号： C12N15/8242 , C12N15/8212 , C12N15/8213 , C12N15/8214
摘要： In one aspect, the invention relates to a transgenic autoluminescent plant including an expressible heterologous nucleotide sequence comprising a bacterial LUX operon, which includes LUX A. LUX B. LUX C. LUX D. LUX b. And LUX G genes, wherein the heterologous nucleotide sequence is expressed to render the plant autonomously luminescent.
摘要翻译： 一方面，本发明涉及包含可包含细菌LUX操纵子的可表达异源核苷酸序列的转基因自发光植物，其包括LUX A.LUX B.LUX C.LUX D.LUX b。 和LUX G基因，其中异源核苷酸序列被表达以使植物自主发光。
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5.发明授权Disk drive adjusting fly height actuator to compensate for laser induced head protrusion in heat assisted magnetic recording 有权磁盘驱动器调节飞行高度执行器，以补偿热辅助磁记录中的激光感应头突出公开(公告)号：US08619508B1
公开(公告)日：2013-12-31
申请号：US13556132
申请日：2012-07-23
IPC分类号： G11B11/00
CPC分类号： G11B5/314 , G11B5/607 , G11B2005/0021
摘要： A disk drive is disclosed comprising a head actuated over a disk, wherein the head comprises a laser operable to heat the disk while writing data to the disk, and a fly height actuator (FHA) operable to adjust a fly height of the head over the disk. When a write command is received to write data to a target data track, the head is positioned over the target data track. When the head approaches a target data sector of the target data track, a power applied to the FHA is increased to decrease the fly height of the head. When the head reaches the target data sector, a power applied to the laser is increased to heat the disk, and the power applied to the FHA is decreased substantially monotonically while writing data to the target data sector.
摘要翻译： 公开了一种磁盘驱动器，其包括在磁盘上致动的磁头，其中所述磁头包括可操作以在将数据写入所述磁盘的同时加热所述磁盘的激光器;以及飞行高度致动器（FHA），其可操作以调整所述磁头 磁盘。 当接收写入命令以将数据写入目标数据轨道时，头部位于目标数据轨道上方。 当头部接近目标数据轨道的目标数据扇区时，增加施加到FHA的功率以降低头部的飞行高度。 当头到达目标数据扇区时，增加施加到激光器的功率以加热盘，并且施加到FHA的功率在将数据写入目标数据扇区的同时基本上单调地减小。
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公开(公告)号：US07232891B2
公开(公告)日：2007-06-19
申请号：US10164914
申请日：2002-06-06
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , G01N33/5091 , G01N33/56966 , G01N33/57492 , G01N33/76 , G01N2333/59 , G01N2333/705
摘要： The subject invention provides a method for detecting the presence of human malignant cells in a sample of tumor cells, which comprises contacting the sample with an antibody directed to an epitope present on the β subunit of human luteinizing hormone or on intact human luteinizing hormone under conditions such that the antibody forms a complex with cells present in the sample if the epitope is present on the surface of the cells, and determining whether the antibody forms such a complex. The subject invention also provides a method for determining whether a tumor present in a human subject is malignant which comprises obtaining a sample of cells from the tumor and detecting the presence of malignant cells in the sample according to the method of the subject invention. Finally, the subject invention provides a method for obtaining an enriched population of live human malignant cells which comprises contacting a population of cells comprising live human malignant cells with an antibody directed to an epitope present on the B subunit of human luteinizing hormone or on intact human luteinizing hormone under conditions such that the antibody forms a complex with the cells present in the population if the epitope is present on the surface of the cells, and isolating the cells which form a complex with the antibody.
摘要翻译： 本发明提供了一种用于检测肿瘤细胞样品中人恶性细胞的存在的方法，其包括使样品与靶向存在于人黄体生成激素的β亚基或完整的人黄体生成激素上的表位的抗体在条件 使得如果表位存在于细胞表面上，并且确定抗体是否形成这样的复合物，则抗体与存在于样品中的细胞形成复合物。 本发明还提供了一种用于确定存在于人类受试者中的肿瘤是否是恶性的方法，其包括从肿瘤获得细胞样品并根据本发明的方法检测样品中恶性细胞的存在。 最后，本发明提供了一种获得活的人类恶性细胞的富集群体的方法，其包括将包含活人恶性细胞的细胞群与针对存在于人黄体生成激素的B亚基上的表位的抗体或完整的人接触 在使细胞存在表位存在的情况下，抗体与存在于群体中的细胞形成复合物的条件下分离与抗体形成复合物的细胞的条件下的促黄体激素。
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公开(公告)号：US20060240028A1
公开(公告)日：2006-10-26
申请号：US10511990
申请日：2003-04-21
CPC分类号： C07K16/1072 , A61K38/00 , A61K2039/505 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2318/10
摘要： The present invention relates to a substance that specifically binds a nuclear localization signal (NLS)-containing molecule. Said substance may be a naturally occurring, synthetic or recombinant antibody, or it may be a protein, a peptide or a small molecule. Preferably, said NLS-containing molecule is a HIV-1 protein, more preferably Vpr or Tat. In addition, the present invention relates to a composition or a vaccine comprising the substance of the invention, as well as methods of inhibiting viral infection through the administration thereof.
摘要翻译： 本发明涉及特异性结合含核定位信号（NLS）的分子的物质。 所述物质可以是天然存在的，合成的或重组的抗体，或者它可以是蛋白质，肽或小分子。 优选地，所述含有NLS的分子是HIV-1蛋白质，更优选为Vpr或Tat。 此外，本发明涉及包含本发明物质的组合物或疫苗，以及通过其施用来抑制病毒感染的方法。
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公开(公告)号：US20220011519A1
公开(公告)日：2022-01-13
申请号：US17483059
申请日：2021-09-23
摘要： In one embodiment, a package includes: a substrate; a photonic integrated circuit (PIC) adapted to the substrate, the PIC including at least one optical circuit, a first plurality of waveguides, a second plurality of waveguides, and a laser to output optical energy via the first plurality of waveguides; and a prism assembly adapted to the substrate to reflect the optical energy output from the first plurality of waveguides to the second plurality of waveguides, the prism assembly including a prism and at least one isolator. Other embodiments are described and claimed.
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9.发明申请Bioluminescent Plants Comprising Bacterial Lux Operon and Methods of Making Same 有权生物发光植物，包括细菌的Lux操纵子及其制作方法公开(公告)号：US20100192262A1
公开(公告)日：2010-07-29
申请号：US12670340
申请日：2008-07-31
申请人： Alexander Krichevsky
发明人： Alexander Krichevsky
CPC分类号： C12N15/8214 , C12N15/8212 , C12N15/8213 , C12N15/8242 , C12N15/825
摘要： In one aspect, the invention relates to a transgenic bioluminescent plant including an expressible heterologous nucleotide sequence comprising a bacterial LUX operon, which includes LUX A, LUX B, LUX C, LUX D, LUX E, and LUX G genes, wherein the heterologous nucleotide sequence is expressed to render the plant bioluminescent.
摘要翻译： 一方面，本发明涉及一种转基因生物发光植物，其包含包含LUX A，LUX B，LUX C，LUX D，LUX E和LUX G基因的细菌LUX操纵子的可表达异源核苷酸序列，其中所述异源核苷酸 表达序列以使植物生物发光。
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10.发明授权Methods of using antibodies against human luteinizing hormone-related determinants to detect and enrich human malignant cells 失效使用针对人黄体生成激素相关决定簇的抗体来检测和富集人类恶性细胞的方法公开(公告)号：US06403326B1
公开(公告)日：2002-06-11
申请号：US08478431
申请日：1995-06-07
IPC分类号： G01N723
CPC分类号： C07K16/26 , G01N33/5091 , G01N33/56966 , G01N33/57492 , G01N33/76 , G01N2333/59 , G01N2333/705
摘要： The subject invention provides a method for detecting the presence of human malignant cells in a sample of tumor cells, which comprises contacting the sample with an antibody directed to an epitope present on the &bgr; subunit of human luteinizing hormone or on intact human luteinizing hormone under conditions such that the antibody forms a complex with cells present in the sample if the epitope is present on the surface of the cells, and determining whether the antibody forms such a complex. The subject invention also provides a method for determining whether a tumor present in a human subject is malignant which comprises obtaining a sample of cells from the tumor and detecting the presence of malignant cells in the sample according to the method of the subject invention. Finally, the subject invention provides a method for obtaining an enriched population of live human malignant cells which comprises contacting a population of cells comprising live human malignant cells with an antibody directed to an epitope present on the &bgr; subunit of human luteinizing hormone or on intact human luteinizing hormone under conditions such that the antibody forms a complex with the cells present in the population if the epitope is present on the surface of the cells, and isolating the cells which form a complex with the antibody.
摘要翻译： 本发明提供了一种用于检测肿瘤细胞样品中人恶性细胞的存在的方法，其包括使样品与靶向存在于人黄体生成激素的β亚基或完整的人黄体生成激素上的表位的抗体在条件 使得如果表位存在于细胞表面上，并且确定抗体是否形成这样的复合物，则抗体与存在于样品中的细胞形成复合物。 本发明还提供了一种用于确定存在于人类受试者中的肿瘤是否是恶性的方法，其包括从肿瘤获得细胞样品并根据本发明的方法检测样品中恶性细胞的存在。 最后，本发明提供了一种获得活的人类恶性细胞的富集群的方法，其包括将包含活人恶性细胞的细胞群与针对存在于人黄体生成激素的β亚基上的表位的抗体或完整的人接触 在使细胞存在表位存在的情况下，抗体与存在于群体中的细胞形成复合物的条件下分离与抗体形成复合物的细胞的条件下的促黄体激素。
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