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1.发明授权Immunization of dairy cattle with GapC protein against Streptococcus infection 有权用GapC蛋白免疫牛链球菌感染的奶牛公开(公告)号：US06833134B2
公开(公告)日：2004-12-21
申请号：US10134297
申请日：2002-04-26
IPC分类号： A61K3909
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/53 , C07K2319/02 , Y10S530/825
摘要： The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S. iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.
摘要翻译： 描述了无义链球菌（Uniformactactiae）（无乳白乳球菌），无乳链球菌（无乳链球菌），乳房链球菌（S.auberis），欧洲链球菌（Streptococcus parauberis）和链球菌（S.iniae））的GapC纤溶酶结合蛋白基因， 以及从其中重组产生GapC蛋白质。 还描述了在疫苗组合物中使用来自那些物种的GapC蛋白质来预防或治疗一般的细菌感染，特别是乳腺炎。
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2.发明授权Immunization of dairy cattle with GapC protein against Streptococcus infection 失效用GapC蛋白免疫牛链球菌感染的奶牛公开(公告)号：US07749516B2
公开(公告)日：2010-07-06
申请号：US11891738
申请日：2007-08-13
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/53 , C07K2319/02 , Y10S530/825
摘要： The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S. iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.
摘要翻译： 描述了无义链球菌（Uniformactactiae）（无乳白乳球菌），无乳链球菌（无乳链球菌），乳房链球菌（乳房链球菌），乳房链球菌（S. parauberis）和链球菌（S.iniae）的GapC纤溶酶结合蛋白基因， 以及从其中重组产生GapC蛋白质。 还描述了在疫苗组合物中使用来自那些物种的GapC蛋白质来预防或治疗一般的细菌感染，特别是乳腺炎。
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3.发明授权Immunization of dairy cattle with GapC protein against Streptococcus infection 有权用GapC蛋白免疫牛链球菌感染的奶牛公开(公告)号：US07273930B2
公开(公告)日：2007-09-25
申请号：US11005508
申请日：2004-12-06
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/53 , C07K2319/02 , Y10S530/825
摘要： The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S. iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.
摘要翻译： 描述了无义链球菌（Uniformactactiae）（无乳白乳球菌），无乳链球菌（无乳链球菌），乳房链球菌（乳房链球菌），乳房链球菌（S. parauberis）和链球菌（S.iniae）的GapC纤溶酶结合蛋白基因， 以及由此产生的GapC蛋白质。 还描述了在疫苗组合物中使用来自那些物种的GapC蛋白质来预防或治疗一般的细菌感染，特别是乳腺炎。
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公开(公告)号：US06866855B2
公开(公告)日：2005-03-15
申请号：US09878781
申请日：2001-06-11
IPC分类号： A61K39/00 , C07K14/315 , C12N1/21 , A61K39/09 , A61K38/00 , A61K39/38 , C07K1/00 , A61K30/02
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/53 , C07K2319/02 , Y10S530/825
摘要： The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S. iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.
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5.发明申请Immunization of dairy cattle with GapC protein against streptococcus infection 失效用GapC蛋白免疫针对链球菌感染的奶牛公开(公告)号：US20080213294A1
公开(公告)日：2008-09-04
申请号：US11891738
申请日：2007-08-13
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/53 , C07K2319/02 , Y10S530/825
摘要： The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S. iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.
摘要翻译： 描述了无义链球菌（Uniformactactiae）（无乳白乳球菌），无乳链球菌（无乳链球菌），乳房链球菌（乳房链球菌），乳房链球菌（S. parauberis）和链球菌（S.iniae）的GapC纤溶酶结合蛋白基因， 以及由此产生的GapC蛋白质。 还描述了在疫苗组合物中使用来自那些物种的GapC蛋白质来预防或治疗一般的细菌感染，特别是乳腺炎。
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公开(公告)号：US06936259B2
公开(公告)日：2005-08-30
申请号：US10134021
申请日：2002-04-26
IPC分类号： G01N33/569 , A61K39/00 , A61K39/09 , A61P15/14 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/08 , A01N63/00 , A61K39/38 , A61K39/395
CPC分类号： C07K14/315 , A61K39/00 , C07K2319/02
摘要： The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including CAMP factor epitopes from more than one bacterial species. The CAMP factors and chimeras including the same can be used in immunogenic compositions for the prevention and treatment of bacterial infections.
摘要翻译： 描述了乳房链球菌（乳房链球菌）的CAMP因子基因，以及从其重组产生CAMP因子。 还公开了嵌合CAMP因子构建体，包括来自多于一种细菌种的CAMP因子表位。 包括其的CAMP因子和嵌合体可用于免疫原性组合物中用于预防和治疗细菌感染。
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7.发明授权Immunization of dairy cattle with chimeric GapC protein against Streptococcus infection 有权用针对链球菌感染的嵌合GapC蛋白免疫奶牛公开(公告)号：US07258992B2
公开(公告)日：2007-08-21
申请号：US11066594
申请日：2005-02-25
IPC分类号： G01N33/53 , G01N33/569 , A61K39/00 , A61K39/09 , C07K14/06 , C07K14/315
CPC分类号： G01N33/56944 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/315 , C07K2319/00 , G01N2469/20
摘要： The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.
摘要翻译： 描述了除了来自婴儿链球菌和无乳链球菌GapC蛋白质的唯一氨基酸序列之外，重组产生包含除了乳酸链球菌GapC蛋白的全部氨基酸序列的嵌合GapC纤溶酶结合蛋白的Gap4。 还描述了Gap4嵌合GapC蛋白在疫苗组合物中的用途，特别是预防或治疗一般的链球菌感染和乳腺炎。
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8.发明授权Immunization of dairy cattle with chimeric GapC protein against Streptococcus infection 有权用针对链球菌感染的嵌合GapC蛋白免疫奶牛公开(公告)号：US06660270B2
公开(公告)日：2003-12-09
申请号：US09878766
申请日：2001-06-11
IPC分类号： A61K3900
CPC分类号： G01N33/56944 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/315 , C07K2319/00 , G01N2469/20
摘要： The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberisand Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.
摘要翻译： 描述了Gap4的重组产物，其包含除了来自巴斯德龙球菌和无乳链球菌GapC蛋白质的唯一氨基酸序列之外的包含脱水链球菌GapC蛋白的全部氨基酸序列的嵌合GapC纤溶酶结合蛋白。 还描述了Gap4嵌合GapC蛋白在疫苗组合物中的用途，特别是预防或治疗一般的链球菌感染和乳腺炎。
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9.发明授权Immunization of dairy cattle with chimeric GapC protein against streptococcus infection 有权用针对链球菌感染的嵌合GapC蛋白免疫奶牛公开(公告)号：US06875853B2
公开(公告)日：2005-04-05
申请号：US10650369
申请日：2003-08-27
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P31/04 , C07K14/315 , C07H21/00 , A61K39/09 , C07H21/04 , C12N15/00 , C12N15/09
CPC分类号： G01N33/56944 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/315 , C07K2319/00 , G01N2469/20
摘要： The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.
摘要翻译： 描述了除了来自婴儿链球菌和无乳链球菌GapC蛋白质的唯一氨基酸序列之外，重组产生包含除了乳酸链球菌GapC蛋白的全部氨基酸序列的嵌合GapC纤溶酶结合蛋白的Gap4。 还描述了Gap4嵌合GapC蛋白在疫苗组合物中的用途，特别是预防或治疗一般的链球菌感染和乳腺炎。
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公开(公告)号：US07700117B2
公开(公告)日：2010-04-20
申请号：US10864012
申请日：2004-06-08
CPC分类号： C07K14/315 , A61K39/00 , C07K2319/02
摘要： The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including CAMP factor epitopes from more than one bacterial species. The CAMP factors and chimeras including the same can be used in immunogenic compositions for the prevention and treatment of bacterial infections.
摘要翻译： 描述了乳房链球菌（乳房链球菌）的CAMP因子基因，以及从其重组产生CAMP因子。 还公开了嵌合CAMP因子构建体，包括来自多于一种细菌种的CAMP因子表位。 包括其的CAMP因子和嵌合体可用于免疫原性组合物中用于预防和治疗细菌感染。
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