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    Screening system for identifying drug-drug interactions and methods of use thereof
    1.
    发明申请
    Screening system for identifying drug-drug interactions and methods of use thereof 审中-公开
    用于鉴定药物 - 药物相互作用的筛选系统及其使用方法

    公开(公告)号：US20080194421A1

    公开(公告)日：2008-08-14

    申请号：US12011051

    申请日：2008-01-24

    申请人： Alexis Borisy ,  Daniel Grau ,  Brent R. Stockwell ,  Curtis Keith

    发明人： Alexis Borisy ,  Daniel Grau ,  Brent R. Stockwell ,  Curtis Keith

    IPC分类号： C40B30/06 ,  C40B30/00

    CPC分类号： C40B30/04 ,  C12Q1/6897 ,  G01N33/5091 ,  G01N33/6845 ,  G01N33/94 ,  G01N2500/00 ,  G01N2500/20

    摘要： The invention features a method of screening for drug-drug interactions using combinational arrays. The method includes the steps of: (a) receiving a test drug from a client; (b) contacting the test drug and at least 200 library drugs from a drug library in an assay under conditions that ensure that each test drug/library drug contacting is segregated from the others; (c) recording the result of the contacting step (b); (d) identifying combinations of drugs that produce a result in the assay that is different from the results produced by either drug of the combination by itself, wherein each identified combination indicates an interaction between the test drug and the library drug of the combination; and (e) communicating the results of the identifying step (d) to the client.

    摘要翻译： 本发明的特征在于使用组合阵列筛选药物 - 药物相互作用的方法。 该方法包括以下步骤：（a）从客户端接收测试药物; （b）在确保每个测试药物/文库药物接触与其他药物分离的条件下，在测定中使测试药物和至少200种文库药物与药物文库接触; （c）记录接触步骤（b）的结果; （d）鉴定在测定中产生与本组合的任一药物产生的结果不同的药物组合，其中每个鉴定的组合表示该组合的测试药物与该文库药物之间的相互作用; 和（e）将识别步骤（d）的结果传达给客户。