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1.发明申请SUBSTITUTED BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 有权作为DPP-1的抑制剂有用的取代的苯并唑和苯并噻唑衍生物公开(公告)号：US20110152287A1
公开(公告)日：2011-06-23
申请号：US12969748
申请日：2010-12-16
申请人： Alfonzo D. Jordan , Renee L. DesJarlais , Dennis J. Hlasta , Michael H. Parker , Carsten Schubert , Kimberly White
发明人： Alfonzo D. Jordan , Renee L. DesJarlais , Dennis J. Hlasta , Michael H. Parker , Carsten Schubert , Kimberly White
IPC分类号： A61K31/496 , C07D417/14 , C07D417/12 , C07D263/58 , A61K31/428 , A61K31/423 , A61P19/02 , A61P11/06 , A61P1/00
CPC分类号： C07D263/58 , C07D277/82 , C07D413/12 , C07D417/12
摘要： The present invention is directed to substituted benzothiazole and benzoxazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及取代的苯并噻唑和苯并恶唑衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况。
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2.发明授权Substituted benzothiazole and benzoxazole derivatives useful as inhibitors of DPP-1 有权可用作DPP-1抑制剂的取代苯并噻唑和苯并恶唑衍生物公开(公告)号：US08481547B2
公开(公告)日：2013-07-09
申请号：US12969748
申请日：2010-12-16
申请人： Alfonzo D. Jordan , Renee L. DesJarlais , Dennis J. Hlasta , Michael H. Parker , Carsten Schubert , Kimberly White
发明人： Alfonzo D. Jordan , Renee L. DesJarlais , Dennis J. Hlasta , Michael H. Parker , Carsten Schubert , Kimberly White
IPC分类号： A61K31/496 , A61K31/423 , A61K31/428 , C07D277/82 , C07D263/58
CPC分类号： C07D263/58 , C07D277/82 , C07D413/12 , C07D417/12
摘要： The present invention is directed to substituted benzothiazole and benzoxazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及取代的苯并噻唑和苯并恶唑衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况。
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公开(公告)号：US08633322B2
公开(公告)日：2014-01-21
申请号：US12914244
申请日：2010-10-28
申请人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
发明人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
IPC分类号： A61K31/445 , C07D211/40
CPC分类号： C07C237/16 , C07C317/32 , C07D211/42 , C07D211/46 , C07D217/02 , C07D307/79 , C07D317/28 , C07D401/12 , C07D409/12
摘要： The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及新型炔基衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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公开(公告)号：US20110105562A1
公开(公告)日：2011-05-05
申请号：US12914244
申请日：2010-10-28
申请人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
发明人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
IPC分类号： A61K31/454 , C07C237/20 , C07D211/46 , C07D401/12 , C07D409/12 , A61K31/165 , A61K31/45 , A61K31/4535 , A61P19/02 , A61P11/06 , A61P11/00 , A61P31/00 , A61P1/00 , A61P9/00
CPC分类号： C07C237/16 , C07C317/32 , C07D211/42 , C07D211/46 , C07D217/02 , C07D307/79 , C07D317/28 , C07D401/12 , C07D409/12
摘要： The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及新型炔基衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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公开(公告)号：US20110152321A1
公开(公告)日：2011-06-23
申请号：US12970247
申请日：2010-12-16
IPC分类号： A61K31/454 , C07D209/18 , A61K31/4045 , C07D401/14 , C07D417/12 , A61K31/427 , C07D403/12 , A61K31/4184 , A61P19/02 , A61P11/06 , A61P11/00 , A61P1/00
CPC分类号： C07D209/14 , C07D209/32 , C07D209/42 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention is directed to novel bicyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及新颖的双环衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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公开(公告)号：US08552032B2
公开(公告)日：2013-10-08
申请号：US12970247
申请日：2010-12-16
IPC分类号： A61K31/343 , A61K31/381 , A61K31/404 , A61K31/4184 , C07D209/04 , C07D235/04 , C07D307/78 , C07D333/52
CPC分类号： C07D209/14 , C07D209/32 , C07D209/42 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention is directed to novel bicyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及新颖的双环衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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7.发明授权4,4-disubstituted piperidine derivatives useful as inhibitors of dipeptidyl peptidase-1 (DPP-1) 有权可用作二肽基肽酶-1（DPP-1）抑制剂的4,4-二取代哌啶衍生物公开(公告)号：US08686152B2
公开(公告)日：2014-04-01
申请号：US13043609
申请日：2011-03-09
IPC分类号： C07D409/06 , C07D405/06 , A61K31/4525 , A61K31/4535
CPC分类号： C07D409/14 , C12N5/0606
摘要： The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及4,4-二取代哌啶衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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8.发明申请4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) 有权作为DIPPTIDYL PEPTIDASE-1（DPP-1）的抑制剂的4,4 - 取代的哌啶衍生物公开(公告)号：US20110224209A1
公开(公告)日：2011-09-15
申请号：US13043609
申请日：2011-03-09
IPC分类号： A61K31/4535 , C07D409/06 , C07D409/14 , C07D211/64 , C07D401/06 , C07D417/14 , C07D413/14 , C07D401/14 , A61K31/4545 , A61K31/451 , A61K31/454 , A61K31/445 , A61K31/5377 , A61K31/4725 , A61K31/506 , A61P29/00 , A61P11/06 , A61P11/00 , A61P1/00 , A61P9/00
CPC分类号： C07D409/14 , C12N5/0606
摘要： The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及4,4-二取代哌啶衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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9.发明申请公开(公告)号：US20120077847A1
公开(公告)日：2012-03-29
申请号：US13245137
申请日：2011-09-26
申请人： Michael N. Greco , Margery A. Connelly , Shyamali Ghosh , Dennis J. Hlasta , Edward C. Lawson , Eric Strobel , Michele A. Weidner-Wells , Hong Ye
发明人： Michael N. Greco , Margery A. Connelly , Shyamali Ghosh , Dennis J. Hlasta , Edward C. Lawson , Eric Strobel , Michele A. Weidner-Wells , Hong Ye
IPC分类号： A61K31/4245 , C07D285/12 , C07D417/12 , A61P7/00 , A61K31/4439 , A61P9/10 , A61P3/06 , C07D271/107 , A61K31/433
CPC分类号： C07D271/10 , C07D249/08 , C07D285/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention is directed to α-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.
摘要翻译： 本发明涉及α-酮酰胺衍生物，含有它们的药物组合物及其用于治疗由内皮脂肪酶调节的病症和状况的用途，例如心血管疾病。
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公开(公告)号：US06583179B2
公开(公告)日：2003-06-24
申请号：US09745283
申请日：2000-12-21
申请人： Steven J. Coats , Louis J. Fitzpatrick , Dennis J. Hlasta , Carolina L. Lanter , Mark J. Macielag , Ke Pan , Ralph A. Rivero , Stephen S. Palmer
发明人： Steven J. Coats , Louis J. Fitzpatrick , Dennis J. Hlasta , Carolina L. Lanter , Mark J. Macielag , Ke Pan , Ralph A. Rivero , Stephen S. Palmer
IPC分类号： A61K3118
CPC分类号： C07D295/185 , C07C237/22 , C07C275/28 , C07C311/13 , C07C311/19 , C07C311/29 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D333/18 , C07D333/34 , C07D405/12 , C07D409/04
摘要： The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the compounds of the invention are antagonists of follicle stimulating hormone, a hormone associated with the human reproductive system.
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