公开(公告)号：US09492525B2

公开(公告)日：2016-11-15

申请号：US13543493

申请日：2012-07-06

申请人： Ali I. Fattom ,  Nicolas Lukacs ,  James R. Baker, Jr. ,  Vira Bitko ,  Tarek Hamouda

发明人： Ali I. Fattom ,  Nicolas Lukacs ,  James R. Baker, Jr. ,  Vira Bitko ,  Tarek Hamouda

IPC分类号： A61K9/107 ,  A61P37/04 ,  A61K39/155 ,  A61K39/12 ,  C07K16/10 ,  C12N7/00 ,  A61K9/00 ,  A61K9/06 ,  A61K9/127 ,  A61K9/51 ,  A61K31/716 ,  A61K31/722 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/1075 ,  A61K9/1271 ,  A61K9/5115 ,  A61K31/716 ,  A61K31/722 ,  A61K47/26 ,  A61K47/38 ,  A61K47/44 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55583 ,  C07K16/1027 ,  C07K2317/33 ,  C07K2317/76 ,  C12N7/00 ,  C12N2760/18521 ,  C12N2760/18522 ,  C12N2760/18534 ,  A61K2300/00

摘要： The present invention relates to RSV vaccines and methods for inducing an immune response to RSV in a subject comprising administering an RSV vaccine.

摘要翻译： 本发明涉及用于在受试者中诱导对RSV的免疫应答的RSV疫苗和方法，包括施用RSV疫苗。

公开(公告)号：US20130064867A1

公开(公告)日：2013-03-14

申请号：US13608317

申请日：2012-09-10

申请人： Ali I. Fattom ,  Tarek Hamouda ,  Vira Bitko ,  James R. Baker, JR.

发明人： Ali I. Fattom ,  Tarek Hamouda ,  Vira Bitko ,  James R. Baker, JR.

IPC分类号： A61K39/155 ,  A61P31/14 ,  A61K9/107

CPC分类号： A61K39/155 ,  A61K9/1075 ,  A61K39/12 ,  A61K47/10 ,  A61K47/186 ,  A61K47/26 ,  A61K47/44 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N2760/18034

摘要： The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.

摘要翻译： 本申请涉及免疫学领域，特别是呼吸道合胞病毒（RSV）表面蛋白，融合（F）和糖蛋白（G）蛋白亚基疫苗的疫苗组合物优先与免疫细胞靶向和增强子混合，纳米乳剂 诱导保护性免疫应答，并避免疫苗诱导疾病增强。

公开(公告)号：US10206996B2

公开(公告)日：2019-02-19

申请号：US13591775

申请日：2012-08-22

申请人： Ali I. Fattom ,  Jakub Simon ,  James R. Baker, Jr. ,  Tarek Hamouda ,  Vira Bitko

发明人： Ali I. Fattom ,  Jakub Simon ,  James R. Baker, Jr. ,  Tarek Hamouda ,  Vira Bitko

IPC分类号： A61K39/00 ,  A61K39/245 ,  A61K39/39 ,  A61K9/107 ,  A61K39/12

摘要： The present application relates to the field of human immunology, in particular, a herpes simplex virus (HSV) vaccine. The subunit vaccine composition comprises isolated surface glycoproteins from herpes simplex viruses, fusion proteins or fragments thereof mixed in varied combination with a nanoemulsion, which is a potent immune enhancer.

公开(公告)号：US09561271B2

公开(公告)日：2017-02-07

申请号：US13608317

申请日：2012-09-10

申请人： Ali I. Fattom ,  Tarek Hamouda ,  Vira Bitko ,  James R. Baker, Jr.

发明人： Ali I. Fattom ,  Tarek Hamouda ,  Vira Bitko ,  James R. Baker, Jr.

IPC分类号： A61K39/155 ,  A61K9/107 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/44 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61K39/155 ,  A61K9/1075 ,  A61K39/12 ,  A61K47/10 ,  A61K47/186 ,  A61K47/26 ,  A61K47/44 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N2760/18034

摘要： The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.

摘要翻译： 本申请涉及免疫学领域，特别是呼吸道合胞病毒（RSV）表面蛋白，融合（F）和糖蛋白（G）蛋白亚基疫苗的疫苗组合物优先与免疫细胞靶向和增强子混合，纳米乳剂 诱导保护性免疫应答，并避免疫苗诱导疾病增强。

公开(公告)号：US20130011443A1

公开(公告)日：2013-01-10

申请号：US13543493

申请日：2012-07-06

申请人： Ali I. Fattom ,  Nicolas Lukacs ,  James R. Baker, JR. ,  Vira Bitko ,  Tarek Hamouda

发明人： Ali I. Fattom ,  Nicolas Lukacs ,  James R. Baker, JR. ,  Vira Bitko ,  Tarek Hamouda

IPC分类号： A61K9/107 ,  A61P37/04 ,  A61K39/155 ,  B82Y5/00

CPC分类号： A61K39/12 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/1075 ,  A61K9/1271 ,  A61K9/5115 ,  A61K31/716 ,  A61K31/722 ,  A61K47/26 ,  A61K47/38 ,  A61K47/44 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55583 ,  C07K16/1027 ,  C07K2317/33 ,  C07K2317/76 ,  C12N7/00 ,  C12N2760/18521 ,  C12N2760/18522 ,  C12N2760/18534 ,  A61K2300/00

摘要： The present invention relates to RSV vaccines and methods for inducing an immune response to RSV in a subject comprising administering an RSV vaccine.

摘要翻译： 本发明涉及用于在受试者中诱导对RSV的免疫应答的RSV疫苗和方法，包括施用RSV疫苗。

公开(公告)号：US20190022210A1

公开(公告)日：2019-01-24

申请号：US15774178

申请日：2016-11-04

申请人： Victor G. Solodushko ,  Brian Fouty ,  Vira Bitko

发明人： Victor G. Solodushko ,  Brian Fouty ,  Vira Bitko

IPC分类号： A61K39/155 ,  A61P31/14 ,  C07K14/005 ,  A61K39/12

摘要： The present invention relates to novel DNA vaccines, configured to induce a robust and sustained immune response, and methods of use thereof. DNA vaccines proposed herein are configured to achieve this immune response by fusing the extracellular domain of a viral fusion protein to selected antigens or antigen-binding polypeptides. After the expression and secretion of the viral fusion-antigen protein from the initially transfected cells, the natural ability of the viral fusion protein to fuse to cell membranes and actively enter cells will allow for passive delivery of the fused target epitopes into neighboring cells, thus inducing a more robust immune response. The presented method described herein allows for the use of this DNA vaccine against known antigens present in proteins produced by infectious agents or cancer cells within a subject, against unknown antigens produced by infectious agents or cancer cells within a subject, or against naturally-occurring or synthetically-derived antigens delivered by other routes, such as injection.