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    Plastic based composite and its use
    2.
    发明授权
    Plastic based composite and its use 失效
    塑料复合材料及其用途

    公开(公告)号：US06353038B1

    公开(公告)日：2002-03-05

    申请号：US09446630

    申请日：2000-02-23

    申请人： Allan Aho ,  Jukka Seppälä ,  Antti Yli-Urpo ,  Jouni Heikkilä ,  Ilkka Kangasniemi

    发明人： Allan Aho ,  Jukka Seppälä ,  Antti Yli-Urpo ,  Jouni Heikkilä ,  Ilkka Kangasniemi

    IPC分类号： C08L3314

    CPC分类号： A61L27/446 ,  A61L27/46 ,  C08L67/04

    摘要： A composite intended for medical use, in particular surgical or therapeutic use, characterized in that it comprises a mixture of a thermoplastic component plasticizable within the temperature range −10° . . . +100° C., which is substantially made up of hydroxy acids and structural units derived from hydroxy acid derivatives and the molar mass of which is within the range 30,000-1,000,000 g/mol, and which degrades in the body typically within a period ranging from a few days to several years, and which in its solid state is a mechanically strong plastic or rubbery material, and a bioactive component, which is a bioactive glass or a bioactive xerogel, such that the plasticized thermoplastic component remains moldable for a certain period even after the temperature of the composite has been lowered to a temperature which is considerably lower than the setting temperature of said thermoplastic component.

    摘要翻译： 一种用于医疗用途，特别是手术或治疗用途的复合材料，其特征在于，其包含在-10°的温度范围内可塑化的热塑性组分的混合物。 。 。 + 100℃，其基本上由羟基酸和衍生自羟基酸衍生物的结构单元组成，其摩尔质量在30,000-1,000,000g / mol范围内，并且其在体内通常在一定范围内降解 从几天到几年，其固体是机械强度强的塑料或橡胶材料，以及作为生物活性玻璃或生物活性干凝胶的生物活性成分，使得增塑的热塑性组分在一定时间内保持模塑，甚至 在复合材料的温度降低到比所述热塑性组分的设定温度低得多的温度之后。

    Method for improvement of soft tissue attachment and implants making use of said method
    3.
    发明授权
    Method for improvement of soft tissue attachment and implants making use of said method 有权
    利用所述方法改善软组织附着和植入物的方法

    公开(公告)号：US07527804B2

    公开(公告)日：2009-05-05

    申请号：US10476157

    申请日：2002-04-25

    申请人： Timo Närhi ,  Hannu Paldan ,  Antti Yli-Urpo ,  Timo Peltola ,  Mika Jokinen ,  Risto-Pekka Happonen

    发明人： Timo Närhi ,  Hannu Paldan ,  Antti Yli-Urpo ,  Timo Peltola ,  Mika Jokinen ,  Risto-Pekka Happonen

    IPC分类号： A61F2/00

    CPC分类号： A61L27/306

    摘要： A method for improving soft tissue attachment which includes the steps of coating a surface of a material, to which surface soft tissue is to be attached, with a coating rich in TiO2 and/or SiO2, and applying the coating where soft tissue attachment is desired. An implant in which a surface or surfaces of the implant intended to be attached to soft tissue are coated with a porous coating rich in TiO2 and/or SiO2, and the use of a porous surface coating rich in TiO2, SiO2, or TiO2 and SiO2, for the manufacture of an implant for soft tissue attachment are also disclosed.

    摘要翻译： 一种用于改善软组织附着的方法，其包括以下步骤：用富含TiO 2和/或SiO 2的涂层涂覆表面软组织附着的材料的表面，并涂覆需要软组织附着的涂层 。 植入物，其中旨在附着到软组织的植入物的表面或表面涂覆有富含TiO 2和/或SiO 2的多孔涂层，并且使用富含TiO 2，SiO 2或TiO 2和SiO 2的多孔表面涂层 ，用于制造用于软组织附着的植入物。

    Multilayered material bearing a biologically active agent and the preparation thereof
    4.
    发明授权
    Multilayered material bearing a biologically active agent and the preparation thereof 有权
    具有生物活性剂的多层材料及其制备方法

    公开(公告)号：US06991802B1

    公开(公告)日：2006-01-31

    申请号：US10069785

    申请日：2000-08-29

    申请人： Manja Ahola ,  Risto Penttinen ,  Anders Södergård ,  Antti Yli-Urpo

    发明人： Manja Ahola ,  Risto Penttinen ,  Anders Södergård ,  Antti Yli-Urpo

    IPC分类号： A61F2/02 ,  A61K9/14

    CPC分类号： A61L31/16 ,  A61L33/0011 ,  A61L2300/608

    摘要： A material for medical use in humans and/or animals bearing a biologically active agent, the material being multilayered, as well as a device of this material and a method to produce it. The material includes a core material, where the core material is formed into a body, optionally having the shape of a finished device; two or more layers of coating material of which the first layer has been applied onto the core material and additional layers have been applied onto the coating material of a preceding layer; and where at least one of the layers includes the biologically active agent. A feature of this invention is that the coating material is a biopolymer, a sol-gel produced silica gel or a biologically active molecule.

    摘要翻译： 用于患有生物活性剂的人类和/或动物的材料，该多层材料，以及该材料的装置及其制造方法。 所述材料包括芯材料，其中芯材料形成为主体，任选地具有成品装置的形状; 将第一层施加到芯材上的两层或更多层涂层材料和附加层已经施加到前一层的涂层材料上; 并且其中至少一层包括生物活性剂。 本发明的一个特征是涂层材料是生物聚合物，溶胶 - 凝胶产生的硅胶或生物活性分子。

    Use of bioactive silicious glass and new compositions containing bioactive silicious glass
    6.
    发明授权
    Use of bioactive silicious glass and new compositions containing bioactive silicious glass 失效
    使用生物活性硅玻璃和含有生物活性硅玻璃的新组合物

    公开(公告)号：US5891233A

    公开(公告)日：1999-04-06

    申请号：US809867

    申请日：1997-04-02

    申请人： Jukka Salonen ,  Ulla Tuominen ,  Antti Yli-Urpo

    发明人： Jukka Salonen ,  Ulla Tuominen ,  Antti Yli-Urpo

    IPC分类号： A61K6/027 ,  A61K6/033 ,  A61K6/06 ,  C03C3/078

    CPC分类号： A61K6/0008 ,  A61K6/0023 ,  A61K6/0038 ,  A61K6/0215 ,  A61K6/0235 ,  A61K6/0276

    摘要： A pharmaceutical preparation, including a glass phase which is bioactive silica containing glass in the form of a paste, suspension or solution mixed in a physiologically suitable liquid or bound to a physiologically suitable vehicle, and which preparation reduces the pulpal irritation or a tooth and/or strengthens the structure of a tooth. Bioactive silica containing glass may be a material which contains only Si-oxide or Si-hydroxide and which allows the formation and movement of Si--OH-groups. Preferably, the preparation also contains calcium and phosphate sources.

    摘要翻译： PCT No.PCT / FI95 / 00539 Sec。 371日期1997年4月2日 102（e）日期1997年4月2日PCT提交1995年10月2日PCT公布。 公开号WO96 / 10985 PCT 日期1996年04月18日一种药物制剂，包括玻璃相，其是生物活性二氧化硅的玻璃形式的糊状物，悬浮液或溶液，混合在生理学上合适的液体中或与生理学合适的载体结合，并且该制剂减少了纸浆刺激 或牙齿和/或加强牙齿的结构。 含有生物活性二氧化硅的玻璃可以是仅含有Si氧化物或Si-氢氧化物并且允许Si-OH基团的形成和移动的材料。 优选地，制剂还含有钙和磷酸盐源。

    Bioceramic system for delivery of bioactive compounds
    7.
    发明授权
    Bioceramic system for delivery of bioactive compounds 失效
    用于生物活性化合物递送的生物陶瓷系统

    公开(公告)号：US5762950A

    公开(公告)日：1998-06-09

    申请号：US438557

    申请日：1995-05-10

    申请人： Antti Yli-Urpo ,  Harry Gosta Jalonen ,  Kauko Oiva Antero Kurkela

    发明人： Antti Yli-Urpo ,  Harry Gosta Jalonen ,  Kauko Oiva Antero Kurkela

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K47/04 ,  A61L24/00 ,  C03C4/00 ,  A61F1/00

    CPC分类号： A61K9/0024 ,  A61K9/2009 ,  C03C4/0007

    摘要： A bioceramic system for delivery of a bioactive compound, which comprises a combination of bioactive glass, bioactive glass ceramic or bioactive ceramic, hydroxyapatite, optionally one or more other calcium phosphate compound and optionally a matrix, and which may incorporate into the bioceramic system a bioactive compound. The timing of the release of the bioactive compound can be regulated as desired and depends on the conditions of the surrounding, the composition of the bioceramic system and its method preparation.

    摘要翻译： 用于递送生物活性化合物的生物陶瓷系统，其包括生物活性玻璃，生物活性玻璃陶瓷或生物活性陶瓷，羟基磷灰石，任选的一种或多种其它磷酸钙化合物和任选的基质的组合，并且其可以并入生物陶瓷体系中的生物活性 复合。 可以根据需要调节生物活性化合物的释放时间，并且取决于周围的条件，生物陶瓷系统的组成及其方法制备。

    Prepreg and its use
    8.
    发明授权
    Prepreg and its use 有权
    预浸料及其用途

    公开(公告)号：US07435764B2

    公开(公告)日：2008-10-14

    申请号：US10558274

    申请日：2004-05-21

    申请人： Pekka Vallittu ,  Antti Yli-Urpo ,  Lippo Lassila ,  Timo Närhi ,  Tuomas Waltimo

    发明人： Pekka Vallittu ,  Antti Yli-Urpo ,  Lippo Lassila ,  Timo Närhi ,  Tuomas Waltimo

    IPC分类号： A61K6/083 ,  A61C5/00

    CPC分类号： A61K6/083 ,  A61C19/063 ,  A61K6/0032 ,  C08L33/00

    摘要： The invention relates to a prepreg comprising a base part, said base part comprising fibers and a matrix, said matrix being at least partially uncured. The prepreg is characterized in that it further comprises a surface part consisting essentially of bioactive filler material, said bioactive filler material being in particle form and at least partially and at most partially embedded in said base part. The invention also relates to a composite obtainable by curing said prepreg. The invention further relates to a mineralizing sheet for treatment of hypersensitive teeth and to the use of said prepreg and composite.

    摘要翻译： 本发明涉及一种预浸料，其包含基体部分，所述基体部分包含纤维和基体，所述基体至少部分未固化。 预浸料的特征在于，其还包括基本上由生物活性填料材料组成的表面部分，所述生物活性填料材料为颗粒形式，并且至少部分且最多部分地嵌入所述基底部分。 本发明还涉及通过固化所述预浸料获得的复合物。 本发明还涉及一种用于治疗过敏牙齿的矿化片以及所述预浸料和复合材料的使用。

    Prepreg and its use
    10.
    发明申请
    Prepreg and its use 有权
    预浸料及其用途

    公开(公告)号：US20070054244A1

    公开(公告)日：2007-03-08

    申请号：US10558274

    申请日：2004-05-21

    申请人： Pekka Vallittu ,  Antti Yli-Urpo ,  Lippo Lassila ,  Timo Narhi ,  Tuomas Waltimo

    发明人： Pekka Vallittu ,  Antti Yli-Urpo ,  Lippo Lassila ,  Timo Narhi ,  Tuomas Waltimo

    IPC分类号： A61C5/00

    CPC分类号： A61K6/083 ,  A61C19/063 ,  A61K6/0032 ,  C08L33/00

    摘要： The invention relates to a prepreg comprising a base part, said base part comprising fibers and a matrix, said matrix being at least partially uncured. The prepreg is characterized in that it further comprises a surface part consisting essentially of bioactive filler material, said bioactive filler material being in particle form and at least partially and at most partially embedded in said base part. The invention also relates to a composite obtainable by curing said prepreg. The invention further relates to a mineralizing sheet for treatment of hypersensitive teeth and to the use of said prepreg and composite.

    摘要翻译： 本发明涉及一种预浸料，其包含基体部分，所述基体部分包含纤维和基体，所述基体至少部分未固化。 预浸料的特征在于，其还包括基本上由生物活性填料材料组成的表面部分，所述生物活性填料材料为颗粒形式，并且至少部分且最多部分地嵌入所述基底部分。 本发明还涉及通过固化所述预浸料获得的复合物。 本发明还涉及一种用于治疗过敏牙齿的矿化片以及所述预浸料和复合材料的用途。