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公开(公告)号：US08600499B2
公开(公告)日：2013-12-03
申请号：US11566896
申请日：2006-12-05
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61F2/82 , A61N1/3688
摘要： A method and device for treating myocardial ischemia in which an implantable pulse generator delivers electrical stimulation to electrodes disposed near a coronary artery. The stimulation parameters may be adjusted to produce vasodilation and/or vasoconstriction of the artery. The device may be configured to operate in a vasodilation and/or vasoconstriction mode in accordance with specified entry and exit conditions.
摘要翻译： 一种用于治疗心肌缺血的方法和装置，其中植入式脉冲发生器将电刺激递送到设置在冠状动脉附近的电极。 可以调节刺激参数以产生动脉的血管舒张和/或血管收缩。 该装置可以被配置为根据指定的入口和出口条件在血管舒张和/或血管收缩模式中操作。
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2.发明授权Automatic adaptation of A-V delay and HR for heart failure using beat to beat measures 有权自动适应心律失常的A-V延迟和人力资源公开(公告)号：US08463380B2
公开(公告)日：2013-06-11
申请号：US13357259
申请日：2012-01-24
申请人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
发明人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译： 描述了调节起搏治疗时间间隔的方法和系统。 对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。 使用调制的定时间隔来提供起搏治疗。
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3.发明授权公开(公告)号：US08131363B2
公开(公告)日：2012-03-06
申请号：US11860957
申请日：2007-09-25
CPC分类号： A61N1/3627
摘要： A device and method for delivering electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The stimulation is delivered as high-output pacing in which the stimulation is excitatory and also of sufficient energy to augment myocardial contractility. In order to provide a consistent hemodynamic response, the high-output pacing is optimized by delivering it using different parameter sets, evaluating the hemodynamic response thereto as reflected by one or more measured physiological variables, and selecting the parameter set with the best hemodynamic response.
摘要翻译： 用于向心脏递送电刺激以改善心力衰竭患者的心脏功能的装置和方法。 刺激作为高产出起搏，其中刺激是兴奋性的，并且具有足够的能量以增加心肌收缩力。 为了提供一致的血流动力学响应，通过使用不同的参数组递送高输出起搏，通过一个或多个测量的生理变量反映的血液动力学响应进行评估，并且选择具有最佳血液动力学响应的参数集来优化高输出起搏。
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公开(公告)号：US20100049270A1
公开(公告)日：2010-02-25
申请号：US12535407
申请日：2009-08-04
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3688
摘要： A device and method for delivering electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The stimulation is delivered as high-output pacing in which the stimulation is excitatory and also of sufficient energy to augment myocardial contractility. The device may be configured to deliver high-output pacing upon detection of cardiac decompensation.
摘要翻译： 用于向心脏递送电刺激以改善心力衰竭患者的心脏功能的装置和方法。 刺激作为高产出起搏，其中刺激是兴奋性的，并且具有足够的能量以增加心肌收缩力。 该装置可以被配置为在检测到心脏代偿失调时递送高输出起搏。
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公开(公告)号：US20100016913A1
公开(公告)日：2010-01-21
申请号：US12504602
申请日：2009-07-16
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3601 , A61N1/36528 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/3684
摘要： A pacing system delivers cardiac protective pacing therapy (CPPT) to protect the heart from injuries and/or to treat existing injuries. The pacing system receives a set of inputs and delivers optimized cardiac protection pacing tailored for each of different purposes. The system delivers electrical stimulation to provide therapy for angina and/or to provide therapy for co-morbidities related to neural imbalance. In one embodiment, a method for treating angina is provided. A signal is sensed indicative of an incidence of angina and an angina region being a myocardial region affected by the angina. The incidence of angina is detected and the angina region is located. A pacing location is selected remote from the angina region, and CPPT is initiated at the pacing location. The CPPT is adapted to create increased stress at the angina region, to promote mass-redistribution and angiogenesis at the angina region to treat the angina.
摘要翻译： 起搏系统提供心脏保护起搏治疗（CPPT），以保护心脏免受伤害和/或治疗现有的伤害。 起搏系统接收一组输入，并提供针对不同目的量身定制的优化的心脏保护起搏。 该系统提供电刺激以提供心绞痛治疗和/或为与神经不平衡相关的并发症提供治疗。 在一个实施方案中，提供了治疗心绞痛的方法。 感测到的信号指示心绞痛的发生率，心绞痛区域是受心绞痛影响的心肌区域。 发现心绞痛发生，心绞痛区域位于。 从心绞痛区域选择起搏位置，并在起搏位置启动CPPT。 CPPT适应于在心绞痛区域产生增加的压力，以促进心绞痛区域的质量再分配和血管生成以治疗心绞痛。
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公开(公告)号：US20090318984A1
公开(公告)日：2009-12-24
申请号：US12484811
申请日：2009-06-15
CPC分类号： A61B17/1204 , A61B17/12109 , A61B17/12136 , A61B2017/22001 , A61B2017/22051 , A61N1/025 , A61N1/056 , A61N1/3625 , A61N1/3627 , A61N1/3706 , A61N1/37241 , A61N1/37264 , G06F19/3481 , G16H40/63
摘要： A pacing system includes a pacemaker and a pacing protocol module externally attached to the pacemaker. The pacing protocol module stores the pacing protocol. The pacemaker controls delivery of pacing pulses by automatically executing the pacing protocol. In one embodiment, the pacing protocol is a cardioprotective pacing protocol for preventing and/or reducing cardiac injury associated with myocardial infarction (MI) and revascularization procedure. The pacing pulses are generated from the pacemaker and delivered through one or more pacing electrodes incorporated onto one or more percutaneous transluminal vascular intervention (PTVI) devices during the revascularization procedure.
摘要翻译： 起搏系统包括外部连接到起搏器的起搏器和起搏协议模块。 起搏协议模块存储起搏协议。 起搏器通过自动执行起搏协议来控制起搏脉冲的传递。 在一个实施方案中，起搏方案是用于预防和/或减少与心肌梗塞（MI）和血运重建术相关的心脏损伤的心脏保护起搏方案。 起搏脉冲从心脏起搏器产生，并通过一个或多个在血运重建过程中并入一个或多个经皮腔内血管介入（PTVI）装置的起搏电极输送。
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公开(公告)号：US20090318749A1
公开(公告)日：2009-12-24
申请号：US12484822
申请日：2009-06-15
CPC分类号： A61N1/056 , A61B5/02028 , A61B5/0215 , A61B5/026 , A61F2/95 , A61N1/3625 , A61N1/3627 , A61N1/36514 , A61N1/36564 , A61N1/36571
摘要： A system delivers multiple enhanced therapies to limit myocardial damage post-revascularization. The system includes a catheter that incorporates features for delivering cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy. In one embodiment, a method for delivering cardiac protection therapies to a heart is provided. One or more catheters are provided having a balloon, at least one pacing electrode and at least one hemodynamic sensor. Cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy are concurrently delivered using the one or more catheters. The pacing and ischemia are adapted to protect the heart from ischemic and reperfusion injuries. The delivery of the CPPT and the intermittent ischemia are controlled using a closed-loop system monitoring a signal sensed by the at least one hemodynamic sensor.
摘要翻译： 系统提供多种增强疗法以限制血运重建后的心肌损伤。 该系统包括导管，其包括用于递送心脏保护起搏治疗（CPPT）和间歇性缺血治疗的特征。 在一个实施方案中，提供了将心脏保护治疗递送至心脏的方法。 提供一个或多个导管，其具有球囊，至少一个起搏电极和至少一个血流动力学传感器。 使用一个或多个导管同时输送心脏保护起搏治疗（CPPT）和间歇性缺血治疗。 起搏和缺血适应于保护心脏免于缺血和再灌注损伤。 CPPT的传送和间歇性缺血通过监视由至少一个血流动力学传感器感测到的信号的闭环系统来控制。
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公开(公告)号：US08972007B2
公开(公告)日：2015-03-03
申请号：US11903758
申请日：2007-09-25
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/36514 , A61N1/36535 , A61N1/36585 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently and variably reduce the AV delay interval used in an atrial triggered pacing mode in a manner that simulates exercise. The device may be programmed to intermittently switch to and from a variably shortened AV delay mode according to defined entry and exit conditions.
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公开(公告)号：US08929983B2
公开(公告)日：2015-01-06
申请号：US12615050
申请日：2009-11-09
申请人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
发明人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
CPC分类号： A61N1/3627 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing. A method and device for applying reverse hysteresis and mode switching to the delivery of such cardioprotective pacing are described.
摘要翻译： 心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。 这种异常收缩负责预激励起搏的所需心脏保护作用。 描述了一种用于将逆向滞后和模式切换应用于这种心脏保护起搏的递送的方法和装置。
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10.发明授权Systems and methods for local vasoactive response using temperature modulation 有权使用温度调制的局部血管活性反应的系统和方法公开(公告)号：US08828068B2
公开(公告)日：2014-09-09
申请号：US11779162
申请日：2007-07-17
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0071 , A61F2007/0075 , A61F2007/126
摘要： Disclosed herein, among other things, is a device for providing a localized vasomodulation of a vessel. According to an embodiment, the device includes a thermal element configured to conduct thermal energy between the thermal element and a desired region of the vessel wall to elicit the localized vasomodulation of the vessel at the desired region. The device also includes a controller operationally connected to the thermal element. The controller is adapted to control the conduction of thermal energy between the thermal element and the desired region of the vessel wall to control the localized vasomodulation of the vessel at the desired region. In various embodiments, a sensor connected to the device provides feedback to the controller.
摘要翻译： 这里公开了一种用于提供血管的局部血管调节的装置。 根据实施例，该装置包括热元件，其被配置为在热元件和容器壁的期望区域之间传导热能，以引起容器在期望区域的局部血管调节。 该装置还包括可操作地连接到热元件的控制器。 控制器适于控制热元件与血管壁的所需区域之间的热能传导，以控制血管在所需区域的局部血管调节。 在各种实施例中，连接到设备的传感器向控制器提供反馈。
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