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    Methods and compositions for treating or preventing peripheral neuropathies
    3.
    发明授权
    Methods and compositions for treating or preventing peripheral neuropathies 失效
    用于治疗或预防周围神经病变的方法和组合物

    公开(公告)号：US06884770B1

    公开(公告)日：2005-04-26

    申请号：US09569386

    申请日：2000-05-11

    申请人： Alphonse Galdes ,  Nagesh Mahanthappa

    发明人： Alphonse Galdes ,  Nagesh Mahanthappa

    IPC分类号： A61K31/00 ,  A61K31/472 ,  A61K31/496 ,  A61K31/553 ,  A61K38/00 ,  A61K38/17 ,  A61K48/00 ,  C07K1/00 ,  C07H21/04 ,  C12N1/20 ,  C12P21/06 ,  G01N33/567

    CPC分类号： A61K31/7076 ,  A61K31/00 ,  A61K31/472 ,  A61K31/496 ,  A61K31/553 ,  A61K38/1709 ,  A61K48/00

    摘要： The present application is directed to the discovery that hedgehog gene products are able to protect peripheral nerve cells under conditions which otherwise result in peripheral neuropathy. Certain aspects of the invention are directed to preparations of hedgehog polypeptides, or other molecules which regulate patched or smoothened signalling, and their uses as protective agents against both acquired and hereditary neuropathies. As used herein, “peripheral neuropathy” refers to a disorder affecting a segment of the peripheral nervous system. For instance, the method of the present invention can be used as part of a treatment program in the management of neuropathies associated with systemic disease, e.g., viral infections, diabetes, inflamation; as well as genetically acquired (hereditary) neuropathies, e.g., Charcot-Marie-Tooth disease; and neuropathies caused by a toxic agent, e.g., a chemotherapeutic agent such as vincristine.

    摘要翻译： 本申请旨在发现刺猬蛋白基因产物能够在否则导致周围神经病变的条件下保护外周神经细胞。 本发明的某些方面涉及刺猬蛋白多肽或调节修补或平滑信号传导的其它分子及其作为对获得性和遗传性神经病的保护剂的用途的制备。 如本文所用，“周围神经病”是指影响周围神经系统的一部分的病症。 例如，本发明的方法可用作治疗与全身疾病相关的神经病的治疗方案的一部分，例如病毒感染，糖尿病，炎症; 以及遗传获得（遗传性）神经病，例如Charcot-Marie-Tooth疾病; 以及由毒性剂例如长春新碱等化学治疗剂引起的神经病变。