Sulfonylpyrrolidine modulators of androgen receptor function and method
    8.
    发明授权
    Sulfonylpyrrolidine modulators of androgen receptor function and method 有权
    磺酰吡咯烷酮调节剂的雄激素受体功能及方法

    公开(公告)号:US07820702B2

    公开(公告)日:2010-10-26

    申请号:US11048439

    申请日:2005-02-01

    IPC分类号: A61K31/433 C07D285/10

    CPC分类号: C07D285/14 C07D207/48

    摘要: Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2, R3, R4, R4a, R4b, R4c, R4c1, Rd, Re, Rf, Rg, Rh, R5, R5′, R7, and R7′ are defined herein; G is aryl, heterocycle or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; and n is an integer of 1 or 2, m is an integer of 1 or 2, Z is oxygen (—O—) or NR4b, a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.

    摘要翻译: 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物,该化合物具有其中R1,R2,R3,R4,R4a,R4b,R4c,R4c1,Rd,Re,Rf ,R g,Rh,R 5,R 5',R 7和R 7'如本文所定义; G是芳基,杂环或杂芳基,其中所述基团是单环或多环,并且其任选被取代; n为1或2的整数,m为1或2的整数,Z为氧(-O-)或NR4b,前药酯,其全部立体异构体及其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。

    Sulfonylpyrrolidine modulators of androgen receptor function and method
    10.
    发明授权
    Sulfonylpyrrolidine modulators of androgen receptor function and method 有权
    磺酰吡咯烷酮调节剂的雄激素受体功能及方法

    公开(公告)号:US07989640B2

    公开(公告)日:2011-08-02

    申请号:US12880692

    申请日:2010-09-13

    IPC分类号: C07D207/00

    CPC分类号: C07D285/14 C07D207/48

    摘要: Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.

    摘要翻译: 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物,该化合物具有其中R1,R2和R4如本文所定义的结构; G是芳基,杂环或杂芳基,其中所述基团是单环或多环,并且其任选被取代; n为1或2的整数; m为1或2的整数; Z是氧(-O-)或NR4h; 前药酯,其所有立体异构体和其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。