-
1.发明授权公开(公告)号：US07256208B2
公开(公告)日：2007-08-14
申请号：US10984502
申请日：2004-11-09
IPC分类号： A61K31/415 , C07D233/00
CPC分类号： C07D233/72 , C07D233/76 , C07D233/78 , C07D233/96
摘要： The present invention relates to novel compounds useful in the treatment of androgen receptor associated conditions, such as age-related diseases, pharmaceutical compositions containing at least one of the compounds of the present invention and methods of treating a patient in need of therapy for an androgen receptor associated condition by administering a therapeutically effective amount of at least compound of the present invention.
摘要翻译： 本发明涉及可用于治疗雄激素受体相关病症例如年龄相关疾病的新化合物，含有至少一种本发明化合物的药物组合物和治疗需要雄激素治疗的患者的方法 受体相关病症，通过施用治疗有效量的至少本发明化合物。
-
2.发明授权公开(公告)号：US07989640B2
公开(公告)日：2011-08-02
申请号：US12880692
申请日：2010-09-13
IPC分类号： C07D207/00
CPC分类号： C07D285/14 , C07D207/48
摘要： Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
摘要翻译： 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物，该化合物具有其中R1，R2和R4如本文所定义的结构; G是芳基，杂环或杂芳基，其中所述基团是单环或多环，并且其任选被取代; n为1或2的整数; m为1或2的整数; Z是氧（-O-）或NR4h; 前药酯，其所有立体异构体和其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。
-
3.发明授权公开(公告)号：US07820702B2
公开(公告)日：2010-10-26
申请号：US11048439
申请日：2005-02-01
IPC分类号： A61K31/433 , C07D285/10
CPC分类号： C07D285/14 , C07D207/48
摘要： Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2, R3, R4, R4a, R4b, R4c, R4c1, Rd, Re, Rf, Rg, Rh, R5, R5′, R7, and R7′ are defined herein; G is aryl, heterocycle or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; and n is an integer of 1 or 2, m is an integer of 1 or 2, Z is oxygen (—O—) or NR4b, a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
摘要翻译： 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物，该化合物具有其中R1，R2，R3，R4，R4a，R4b，R4c，R4c1，Rd，Re，Rf ，R g，Rh，R 5，R 5'，R 7和R 7'如本文所定义; G是芳基，杂环或杂芳基，其中所述基团是单环或多环，并且其任选被取代; n为1或2的整数，m为1或2的整数，Z为氧（-O-）或NR4b，前药酯，其全部立体异构体及其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。
-
4.发明申请公开(公告)号：US20110015408A1
公开(公告)日：2011-01-20
申请号：US12880692
申请日：2010-09-13
IPC分类号： C07D207/48
CPC分类号： C07D285/14 , C07D207/48
摘要： Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure whereinR1, R2 and R4, are as defined herein;G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted;n is an integer of 1 or 2;m is an integer of 1 or 2;Z is oxygen (—O—) or NR4h;a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
摘要翻译： 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物，该化合物具有其中R1，R2和R4如本文所定义的结构; G是芳基，杂环或杂芳基，其中所述基团是单环或多环，并且其任选被取代; n为1或2的整数; m为1或2的整数; Z是氧（-O-）或NR4h; 前药酯，其所有立体异构体和其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。
-
公开(公告)号：US20110245264A1
公开(公告)日：2011-10-06
申请号：US12895916
申请日：2010-10-01
申请人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
发明人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
IPC分类号： A61K31/496 , C07D333/24 , A61K31/381 , C07D409/12 , C07C233/60 , A61K31/165 , A61P25/28 , A61P25/18 , A61P25/16 , A61P25/30
CPC分类号： C07D333/24 , C07C233/60 , C07C2601/02
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
-
6.发明申请(S)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE 审中-公开（S） - 苯基（甲基）甲基化合物，包含它们的组合物及其使用方法公开(公告)号：US20090181992A1
公开(公告)日：2009-07-16
申请号：US12409640
申请日：2009-03-24
IPC分类号： A61K31/506 , C07D239/47 , A61P25/00
CPC分类号： C07D401/04
摘要： Multicyclic compounds and pharmaceutical compositions comprising them are described, along with methods of their use in the treatment of diseases such as age-associated memory impairment, Alzheimer's disease, Attention-Deficit/Hyperactivity Disorder (ADD/ADHD), autism, Down syndrome, Fragile X syndrome, Huntington's disease, Parkinson's disease, and schizophrenia. Compounds include those of formula I:
摘要翻译： 描述了包含它们的多环化合物和药物组合物，以及它们用于治疗诸如年龄相关记忆障碍，阿尔茨海默病，注意力缺陷/多动障碍（ADD / ADHD），自闭症，唐氏综合征，脆弱性 X综合征，亨廷顿病，帕金森病和精神分裂症。 化合物包括式I的化合物：
-
7.发明申请(R)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE 审中-公开（R） - 苯基（杂环）甲醇基化合物，包含它们的组合物及其使用方法公开(公告)号：US20080146596A1
公开(公告)日：2008-06-19
申请号：US11935051
申请日：2007-11-05
IPC分类号： A61K31/513 , C07D401/04 , C07K14/435 , A61P25/18 , A61P25/00 , A61P25/28 , A61P25/16 , A61K31/506
CPC分类号： C07D401/04
摘要： Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described. Compounds described include those of formula I:
摘要翻译： 描述了多环化合物，包含它们的药物组合物及其使用方法。 描述的化合物包括式I的化合物：
-
公开(公告)号：US07384958B2
公开(公告)日：2008-06-10
申请号：US11680662
申请日：2007-03-01
申请人： Yingzhi Bi , Guixue Yu , David P. Rotella , John E. Macor
发明人： Yingzhi Bi , Guixue Yu , David P. Rotella , John E. Macor
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D405/12 , A61K31/47 , A61K31/4709 , C07D215/42 , C07D215/48 , C07D215/54 , C07D401/04 , C07D401/12 , C07D417/12 , C07D491/10
摘要： Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
-
公开(公告)号：US20070155788A1
公开(公告)日：2007-07-05
申请号：US11680662
申请日：2007-03-01
申请人： Yingzhi Bi , Guixue Yu , David Rotella , John Macor
发明人： Yingzhi Bi , Guixue Yu , David Rotella , John Macor
IPC分类号： A61K31/4706 , C07D215/38 , A61K31/4709
CPC分类号： C07D405/12 , A61K31/47 , A61K31/4709 , C07D215/42 , C07D215/48 , C07D215/54 , C07D401/04 , C07D401/12 , C07D417/12 , C07D491/10
摘要： Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
摘要翻译： 式（I）的化合物可用作cGMP PDE特别是5型的抑制剂。
-
公开(公告)号：US08304577B2
公开(公告)日：2012-11-06
申请号：US12898016
申请日：2010-10-05
申请人： Carolyn Diane Dzierba , Richard A. Hartz , Yingzhi Bi , Vijay T. Ahuja , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Michael Green , David Kimball , S. Roy Kimura , Soojin Kwon , John E. Macor , Yulian Zhang , Greg Zipp
发明人： Carolyn Diane Dzierba , Richard A. Hartz , Yingzhi Bi , Vijay T. Ahuja , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Michael Green , David Kimball , S. Roy Kimura , Soojin Kwon , John E. Macor , Yulian Zhang , Greg Zipp
IPC分类号： C07C233/00
CPC分类号： C07D207/40 , C07B2200/07 , C07C233/22 , C07C233/40 , C07C237/06 , C07C2601/02 , C07C2601/08 , C07D213/40 , C07D231/12 , C07D277/32
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
摘要翻译： 本公开一般涉及可以调节G蛋白偶联受体88的化合物，包含这些化合物的组合物，以及调节G蛋白偶联受体88的方法。
-
-
-
-
-
-
-
-
-
搜索结果
34 条记录 (耗时 0.032 秒)
