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    Sulfonylpyrrolidine modulators of androgen receptor function and method
    2.
    发明授权
    Sulfonylpyrrolidine modulators of androgen receptor function and method 有权
    磺酰吡咯烷酮调节剂的雄激素受体功能及方法

    公开(公告)号：US07989640B2

    公开(公告)日：2011-08-02

    申请号：US12880692

    申请日：2010-09-13

    申请人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    发明人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    IPC分类号： C07D207/00

    CPC分类号： C07D285/14 ,  C07D207/48

    摘要： Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.

    摘要翻译： 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物，该化合物具有其中R1，R2和R4如本文所定义的结构; G是芳基，杂环或杂芳基，其中所述基团是单环或多环，并且其任选被取代; n为1或2的整数; m为1或2的整数; Z是氧（-O-）或NR4h; 前药酯，其所有立体异构体和其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。

    Sulfonylpyrrolidine modulators of androgen receptor function and method
    3.
    发明授权
    Sulfonylpyrrolidine modulators of androgen receptor function and method 有权
    磺酰吡咯烷酮调节剂的雄激素受体功能及方法

    公开(公告)号：US07820702B2

    公开(公告)日：2010-10-26

    申请号：US11048439

    申请日：2005-02-01

    申请人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    发明人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    IPC分类号： A61K31/433 ,  C07D285/10

    CPC分类号： C07D285/14 ,  C07D207/48

    摘要： Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2, R3, R4, R4a, R4b, R4c, R4c1, Rd, Re, Rf, Rg, Rh, R5, R5′, R7, and R7′ are defined herein; G is aryl, heterocycle or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; and n is an integer of 1 or 2, m is an integer of 1 or 2, Z is oxygen (—O—) or NR4b, a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.

    摘要翻译： 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物，该化合物具有其中R1，R2，R3，R4，R4a，R4b，R4c，R4c1，Rd，Re，Rf ，R g，Rh，R 5，R 5'，R 7和R 7'如本文所定义; G是芳基，杂环或杂芳基，其中所述基团是单环或多环，并且其任选被取代; n为1或2的整数，m为1或2的整数，Z为氧（-O-）或NR4b，前药酯，其全部立体异构体及其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。

    SULFONYLPYRROLIDINE MODULATORS OF ANDROGEN RECEPTOR FUNCTION AND METHOD
    4.
    发明申请
    SULFONYLPYRROLIDINE MODULATORS OF ANDROGEN RECEPTOR FUNCTION AND METHOD 有权
    雄激素受体功能和方法的磺酰胆碱调节剂

    公开(公告)号：US20110015408A1

    公开(公告)日：2011-01-20

    申请号：US12880692

    申请日：2010-09-13

    申请人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    发明人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    IPC分类号： C07D207/48

    CPC分类号： C07D285/14 ,  C07D207/48

    摘要： Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure whereinR1, R2 and R4, are as defined herein;G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted;n is an integer of 1 or 2;m is an integer of 1 or 2;Z is oxygen (—O—) or NR4h;a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.

    摘要翻译： 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物，该化合物具有其中R1，R2和R4如本文所定义的结构; G是芳基，杂环或杂芳基，其中所述基团是单环或多环，并且其任选被取代; n为1或2的整数; m为1或2的整数; Z是氧（-O-）或NR4h; 前药酯，其所有立体异构体和其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。

    Open chain prolyl urea-related modulators of androgen receptor function
    7.
    发明授权
    Open chain prolyl urea-related modulators of androgen receptor function 有权
    开链脯氨酰脲相关调节剂的雄激素受体功能

    公开(公告)号：US07632858B2

    公开(公告)日：2009-12-15

    申请号：US10712456

    申请日：2003-11-13

    申请人： Lawrence G. Hamann ,  David J. Augeri ,  Mark C. Manfredi

    发明人： Lawrence G. Hamann ,  David J. Augeri ,  Mark C. Manfredi

    IPC分类号： C07D207/12 ,  A61K31/4015 ,  A61P35/00

    CPC分类号： C07D207/16 ,  C07D401/12

    摘要： The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein R1, R2, R3, X, Y, Z and G are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.

    摘要翻译： 本发明提供能够调节包含式I化合物的雄激素受体的药物组合物，其中R 1，R 2，R 3，X，Y，Z和G如本文所述。 还提供了使用这些化合物治疗核激素受体相关病症（如与年龄相关的疾病，例如肌肉减少症）的方法，并且还提供含有这些化合物的药物组合物。

    Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
    10.
    发明授权
    Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors 有权
    杂芳基11-β-羟基类固醇脱氢酶I型抑制剂

    公开(公告)号：US07572807B2

    公开(公告)日：2009-08-11

    申请号：US11448946

    申请日：2006-06-07

    申请人： James J. Li ,  Lawrence G. Hamann ,  Haixia Wang

    发明人： James J. Li ,  Lawrence G. Hamann ,  Haixia Wang

    IPC分类号： A01N43/42 ,  A61K31/44 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02

    CPC分类号： C07D471/04

    摘要： Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: W-L-Z  (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, L and Z are defined herein.

    摘要翻译： 提供了新的化合物，其为11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。 这些新化合物具有以下结构：<？in-line-formula description =“In-line Formulas”end =“lead”？> WLZ（I）<？in-line-formula description =“In-line Formulas”end = 或其立体异构体或前药或其药学上可接受的盐，其中W，L和Z在本文中定义。