公开(公告)号：US06555376B2

公开(公告)日：2003-04-29

申请号：US10201247

申请日：2002-07-24

申请人： Amarnath Maitra ,  Subho Mozumdar ,  Susmita Mitra ,  Indrajit Roy

发明人： Amarnath Maitra ,  Subho Mozumdar ,  Susmita Mitra ,  Indrajit Roy

IPC分类号： C12N1588

CPC分类号： B82Y5/00 ,  A61K47/549 ,  A61K47/6923 ,  A61K47/6929 ,  C12N15/88

摘要： The present invention relates to a process of entrapping genetic materials in nanoparticles of inorganic metal salts of size below 100 nm diameter to form non-viral carriers for delivery of genes. The process comprises the steps of dissolving surfactants and a cosurfactant in oil to obtain reverse micelles. An aqueous solution of genetic material is added to the reverse micelles. Thereafter the reverse micelles are divided into two equal parts. To one part, aqueous solution of inorganic metal salts is dissolved to obtain optically clear and transparent reverse micelles. To the second part aqueous solution of precipitating agent is added to obtain optically clear and transparent reverse micelles. The two equally divided parts of reverse micelles are mixed to form inorganic nanopartcles encapsulating added genetic material. Thereafter, the nanoparticles are separated from reverse micelles, the inorganic nanoparticles are dispersed in water and dialyzed to remove free metal salts, surfactant and oil.

摘要翻译： 本发明涉及一种在大于100nm直径的无机金属盐的纳米颗粒中捕获遗传物质以形成用于递送基因的非病毒载体的方法。 该方法包括将表面活性剂和辅助表面活性剂溶解在油中以获得反胶束的步骤。 将遗传物质的水溶液加入到反胶束中。 此后将反胶束分成两等份。 一方面，将无机金属盐的水溶液溶解，得到透明透明的反胶束。 向第二部分添加沉淀剂水溶液以获得光学透明且透明的反胶束。 将两个等分的部分反胶束混合以形成包封添加的遗传物质的无机纳米颗粒。 此后，将纳米颗粒与反胶束分离，将无机纳米颗粒分散在水中并透析以除去游离金属盐，表面活性剂和油。

公开(公告)号：US08832050B2

公开(公告)日：2014-09-09

申请号：US13416603

申请日：2012-03-09

申请人： Nathan L. Binkert ,  Wojciech Golab ,  Indrajit Roy ,  Mehul A. Shah ,  Benjamin A. Sowell

发明人： Nathan L. Binkert ,  Wojciech Golab ,  Indrajit Roy ,  Mehul A. Shah ,  Benjamin A. Sowell

IPC分类号： G06F17/30

CPC分类号： G06F17/30961

摘要： A distributed balanced tree having a plurality of nodes distributed across a plurality of servers is accessed. Version information associated with a node of the distributed balanced tree is retrieved. Validity of a lookup transaction performed on the balanced tree is determined by verifying a version value of only the leaf node accessed during the lookup operation against the retrieved version information.

摘要翻译： 访问分布在多个服务器上的多个节点的分布式平衡树被访问。 检索与分布式平衡树的节点相关联的版本信息。 在平衡树上执行的查找事务的有效性是通过仅针对检索到的版本信息检查在查找操作期间访问的叶节点的版本值来确定的。

公开(公告)号：US20140033214A1

公开(公告)日：2014-01-30

申请号：US13562248

申请日：2012-07-30

申请人： Shivaram Venkataraman ,  Indrajit Roy ,  Mehul A. Shah ,  Robert Schreiber ,  Nathan Lorenzo Binkert ,  Parthasarathy Ranganathan

发明人： Shivaram Venkataraman ,  Indrajit Roy ,  Mehul A. Shah ,  Robert Schreiber ,  Nathan Lorenzo Binkert ,  Parthasarathy Ranganathan

IPC分类号： G06F9/46

CPC分类号： G06F9/5088 ,  G06F9/4881 ,  G06F9/5066

摘要： A plurality of array partitions are defined for use by a set of tasks of the program run-time. The array partitions can be determined from one or more arrays that are utilized by the program at run-time. Each of the plurality of computing devices are assigned to perform one or more tasks in the set of tasks. By assigning each of the plurality of computing devices to perform one or more tasks, an objective to reduce data transfer amongst the plurality of computing devices can be implemented.

摘要翻译： 定义多个阵列分区以供程序运行时的一组任务使用。 阵列分区可以从程序在运行时使用的一个或多个数组确定。 分配多个计算设备中的每一个以执行该组任务中的一个或多个任务。 通过分配多个计算设备中的每一个来执行一个或多个任务，可以实现减少多个计算设备之间的数据传输的目的。

公开(公告)号：US20130238576A1

公开(公告)日：2013-09-12

申请号：US13416603

申请日：2012-03-09

申请人： Nathan L. Binkert ,  Wojciech Golab ,  Indrajit Roy ,  Mehul A. Shah ,  Benjamin A. Sowell

发明人： Nathan L. Binkert ,  Wojciech Golab ,  Indrajit Roy ,  Mehul A. Shah ,  Benjamin A. Sowell

IPC分类号： G06F7/00

CPC分类号： G06F17/30961

摘要： A distributed balanced tree having a plurality of nodes distributed across a plurality of servers is accessed. Version information associated with a node of the distributed balanced tree is retrieved. Validity of a lookup transaction performed on the balanced tree is determined by verifying a version value of only the leaf node accessed during the lookup operation against the retrieved version information.

摘要翻译： 访问分布在多个服务器上的多个节点的分布式平衡树被访问。 检索与分布式平衡树的节点相关联的版本信息。 在平衡树上执行的查找事务的有效性是通过仅针对检索到的版本信息检查在查找操作期间访问的叶节点的版本值来确定的。

公开(公告)号：US07364754B2

公开(公告)日：2008-04-29

申请号：US10764677

申请日：2004-01-26

申请人： Paras Prasad ,  Indrajit Roy ,  Earl J. Bergey ,  Tymish Y. Ohulchansky ,  Haridas Pudavar

发明人： Paras Prasad ,  Indrajit Roy ,  Earl J. Bergey ,  Tymish Y. Ohulchansky ,  Haridas Pudavar

IPC分类号： A61K9/14 ,  A61K31/57

CPC分类号： A61K9/5115 ,  A61K31/555 ,  A61K41/0057 ,  A61K41/0071 ,  B82Y5/00

摘要： The present invention provides methods and compositions for photodynamic therapy. The composition comprises ceramic nanoparticles in which a photosensitive drug/dye is entrapped. The ceramic nanoparticles are made by formation of a micellar composition of the dye. The ceramic material is added to the micellar composition and the ceramic nanoparticles are precipitated by alkaline hydrolysis. The precipitated nanoparticles in which the photosensitive dye/drug is entrapped can be isolated by dialysis. The resulting drug doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. Irradiation with light of suitable wavelength of the photosensitizing drug entrapped inside nanoparticles resulted in generation of singlet oxygen, which was able to diffuse out through the pores of the ceramic matrix. The drug loaded ceramic nanoparticles of the present invention can be used as drug carriers for photodynamic therapy.

摘要翻译： 本发明提供光动力疗法的方法和组合物。 该组合物包含其中包含光敏药物/染料的陶瓷纳米颗粒。 通过形成染料的胶束组合物制备陶瓷纳米颗粒。 将陶瓷材料加入到胶束组合物中，并通过碱水解沉淀陶瓷纳米颗粒。 可以通过透析分离感光性染料/药物被捕获的沉淀的纳米粒子。 所得药物掺杂的纳米颗粒是球形的，高度单分散的，并且在水性体系中稳定。 用纳米颗粒内的光敏药物的合适波长的光照射导致产生单线态氧，其能够通过陶瓷基质的孔扩散出来。 本发明的载药陶瓷纳米颗粒可用作光动力疗法的药物载体。

公开(公告)号：US09690679B2

公开(公告)日：2017-06-27

申请号：US13285884

申请日：2011-10-31

申请人： Mehul A. Shah ,  Wojciech Golab ,  Indrajit Roy ,  Nathan Lorenzo Binkert ,  Stavros Harizopoulos

发明人： Mehul A. Shah ,  Wojciech Golab ,  Indrajit Roy ,  Nathan Lorenzo Binkert ,  Stavros Harizopoulos

IPC分类号： G06F17/30 ,  G06F11/20 ,  G06F11/16 ,  G06F11/18 ,  G06Q10/10 ,  G06F11/14

CPC分类号： G06F11/2035 ,  G06F11/1425 ,  G06F11/1474 ,  G06F11/1658 ,  G06F11/1666 ,  G06F11/183 ,  G06F11/2023 ,  G06Q10/10

摘要： An embodiment provides a system and method for transaction commitment and replication. The method includes receiving a minitransaction from a client node at one or more memory nodes, wherein each memory node includes a number of replicas. The minitransaction is a type of transaction which atomically executes any combination of reading, comparing, and writing to any of a number of memory locations. The method also includes determining, for a leader of the replicas within a memory node, whether the leader is able to commit the minitransaction and stabilizing state changes of the minitransaction within a transaction log using a consensus procedure to update the replicas. The method further includes committing the minitransaction if, at each memory node, a quorum of the replicas is able to stabilize the minitransaction, or aborting the minitransaction otherwise.

公开(公告)号：US08938599B2

公开(公告)日：2015-01-20

申请号：US13421651

申请日：2012-03-15

申请人： Michael Mihn-Jong Lee ,  Indrajit Roy ,  Vanish Talwar ,  Alvin AuYoung ,  Parthasarathy Ranganathan

发明人： Michael Mihn-Jong Lee ,  Indrajit Roy ,  Vanish Talwar ,  Alvin AuYoung ,  Parthasarathy Ranganathan

IPC分类号： G06F12/02

CPC分类号： G06F12/0284

摘要： In a method of implementing a graph storage system, the graph storage system is stored on a plurality of computing systems. A global address space is provided for distributed graph storage. The global address space is managed with graph allocators, in which a graph allocator allocates space from a block of the distributed global memory in order to store a plurality of graphs.

摘要翻译： 在实现图形存储系统的方法中，图形存储系统被存储在多个计算系统上。 为分布式图形存储提供了全局地址空间。 全局地址空间由图形分配器管理，其中图形分配器从分布式全局存储器的块分配空间以存储多个图形。

公开(公告)号：US08035016B2

公开(公告)日：2011-10-11

申请号：US12555609

申请日：2009-09-08

申请人： Earl J. Bergey ,  Adela Bonoiu ,  Supriya Mahajan ,  Paras N. Prasad ,  Indrajit Roy ,  Stanley A. Schwartz ,  Ken-Tye Yong

发明人： Earl J. Bergey ,  Adela Bonoiu ,  Supriya Mahajan ,  Paras N. Prasad ,  Indrajit Roy ,  Stanley A. Schwartz ,  Ken-Tye Yong

IPC分类号： A61P43/00 ,  C12N15/113

CPC分类号： C12N15/111 ,  A61K9/5115 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  Y10S977/773

摘要： Provided are methods and compositions for inhibiting expression of one or more target genes. The compositions contain RNA polynucleotides that can inhibit expression of a target gene via RNA interference (RNAi) electrostatically complexed with surface functionalized gold nanorods (GNRs). The RNA polynucleotides are not covalently bound to the surface functionalized GNRs. The method involves inhibiting expression of a target gene in an individual. The method is performed by administering to the individual an effective amount of a composition containing surface functionalized GNRs electrostatically complexed with RNA polynucleotides, such as siRNA, that can inhibit expression of the target gene via RNAi. The siRNA is not covalently bound to the surface functionalized GNRs.

摘要翻译： 提供了用于抑制一种或多种靶基因表达的方法和组合物。 组合物含有可通过与表面官能化金纳米棒（GNR）静电复合的RNA干扰（RNAi）抑制靶基因表达的RNA多核苷酸。 RNA多核苷酸不共价结合表面官能化的GNRs。 该方法涉及抑制个体中靶基因的表达。 该方法通过向个体施用有效量的含有可以通过RNAi抑制靶基因表达的RNA多核苷酸（例如siRNA）静电复合的表面官能化GNR的组合物来进行。 siRNA不与表面官能化的GNR共价结合。

公开(公告)号：US20160034528A1

公开(公告)日：2016-02-04

申请号：US14775329

申请日：2013-03-15

申请人： Indrajit ROY ,  Feng LIU ,  Vanish TALWAR ,  Shimin CHEN ,  Jichuan CHANG ,  Parthasarathy RANGANATHAN ,  HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

发明人： Indrajit Roy ,  Feng Liu ,  Vanish Talwar ,  Shimin Chen ,  Jichuan Chang ,  Parthasarathy Ranganathan

IPC分类号： G06F17/30

CPC分类号： G06F16/245 ,  G06F9/5005 ,  G06F9/5066 ,  G06F16/21 ,  G06F16/24554 ,  G06F16/283

摘要： A technique includes receiving a user input in an array-oriented database. The user input indicates a database operation and processing a plurality of chunks of data stored by the database to perform the operation. The processing in dudes selectively distributing the processing of the plurality of chunks between a first group of at least one central processing unit and a second group of at least one co-processor.

摘要翻译： 一种技术包括在面向数组的数据库中接收用户输入。 用户输入指示数据库操作并处理由数据库存储的多个数据块以执行操作。 所述处理在所述至少一个中央处理单元的第一组和至少一个协处理器的第二组之间选择性地分布所述多个块的处理。

公开(公告)号：US20140019490A1

公开(公告)日：2014-01-16

申请号：US13549112

申请日：2012-07-13

申请人： Indrajit Roy ,  Alvin Au Young ,  Vanish Talwar ,  Michael Mihn-Jong Lee

发明人： Indrajit Roy ,  Alvin Au Young ,  Vanish Talwar ,  Michael Mihn-Jong Lee

IPC分类号： G06F17/30

CPC分类号： G06F17/30286 ,  G06F17/30073 ,  G06F17/30321 ,  G06F17/30587 ,  G06F17/30958

摘要： Examples of the present disclosure may include methods, systems, and computer readable media with executable instructions. An example method for event processing for graph-structured data can include storing graph structured data. The graph structured data includes a plurality of vertex, edge, and/or property graph elements. The example method further includes defining a first graph view of a characteristic of vertex, edge, and/or property graph elements. A subgraph is determined as a subset of the plurality of vertex, edge, and/or property graph elements that have the characteristic of vertex, edge, and/or property graph elements defined by the first graph view. The vertex, edge, and/or property graph elements of the subgraph are processed responsive to a predefined event that occurs on at least one of the vertex, edge, and/or property graph elements of the subgraph.

摘要翻译： 本公开的示例可以包括具有可执行指令的方法，系统和计算机可读介质。 用于图形结构化数据的事件处理的示例方法可以包括存储图形结构化数据。 图形结构化数据包括多个顶点，边缘和/或属性图形元素。 示例性方法还包括定义顶点，边缘和/或属性图表元素的特征的第一图形视图。 子图被确定为具有由第一图形视图定义的顶点，边缘和/或属性图形元素的特征的多个顶点，边缘和/或属性图形元素的子集。 响应于发生在子图的顶点，边缘和/或属性图表元素中的至少一个上的预定义事件来处理子图的顶点，边缘和/或属性图形元素。