公开(公告)号：US08959448B2

公开(公告)日：2015-02-17

申请号：US12104234

申请日：2008-04-16

申请人： Amedeo Joseph Cappione, III ,  Ray Lefebvre ,  Neil Kilcoin ,  David Andrew King ,  George J. Dixon

发明人： Amedeo Joseph Cappione, III ,  Ray Lefebvre ,  Neil Kilcoin ,  David Andrew King ,  George J. Dixon

IPC分类号： G06F3/048 ,  G01N35/00 ,  G06F19/26 ,  G01N15/14

CPC分类号： G06F19/26 ,  G01N35/00722 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2035/0091 ,  G06F3/04817

摘要： A graphical user interface on a computer provides for the analysis of location specific data and the presentation of analysis results for visual comparison by a user. Results of the analysis are visually presented as icons subdivided into regions and arranged in such a way that the user is able to associate each icon with a data location. A visual presentation of results in the icons and regions allows a user to visually compare the analysis results in two or more data sets according to location. The graphical user interface further provides for the definition and adjustment of an analysis through the interaction of a user with a graphical representation of the analysis. In some cases, the visual presentation of results tracks the analysis adjustments so the user can visually observe the effects that the adjustments have on the results. A method of interacting with the interface to define an analysis and represent results and a method of presenting two or more data sets using the interface are described. The interface can be used to analyze and visually compare the results of location specific data from a number of sources and is illustrated in a flow cytometry application.

摘要翻译： 计算机上的图形用户界面提供对位置特定数据的分析和分析结果的呈现，以供用户视觉比较。 分析结果以视觉方式呈现为按区域划分的图标，并以这样一种方式排列，使得用户能够将每个图标与数据位置相关联。 在图标和区域中的视觉呈现结果允许用户根据位置在两个或多个数据集中视觉比较分析结果。 图形用户界面还通过用户与分析的图形表示的交互来进一步提供对分析的定义和调整。 在某些情况下，结果的视觉呈现跟踪分析调整，以便用户可以直观地观察调整对结果的影响。 描述了与接口交互以定义分析并表示结果的方法以及使用该接口呈现两个或多个数据集的方法。 界面可用于分析和视觉比较来自多个来源的位置特定数据的结果，并在流式细胞术应用中进行了说明。

公开(公告)号：US20080263468A1

公开(公告)日：2008-10-23

申请号：US12104234

申请日：2008-04-16

申请人： Amedeo Joseph Cappione ,  Ray Lefebvre ,  Neil Kilcoin ,  David Andrew King ,  George J. Dixon

发明人： Amedeo Joseph Cappione ,  Ray Lefebvre ,  Neil Kilcoin ,  David Andrew King ,  George J. Dixon

IPC分类号： G06F3/048 ,  G06F19/00

CPC分类号： G06F19/26 ,  G01N35/00722 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2035/0091 ,  G06F3/04817

摘要： A graphical user interface on a computer provides for the analysis of location specific data and the presentation of analysis results for visual comparison by a user. Results of the analysis are visually presented as icons subdivided into regions and arranged in such a way that the user is able to associate each icon with a data location. A visual presentation of results in the icons and regions allows a user to visually compare the analysis results in two or more data sets according to location. The graphical user interface further provides for the definition and adjustment of an analysis through the interaction of a user with a graphical representation of the analysis. In some cases, the visual presentation of results tracks the analysis adjustments so the user can visually observe the effects that the adjustments have on the results. A method of interacting with the interface to define an analysis and represent results and a method of presenting two or more data sets using the interface are described. The interface can be used to analyze and visually compare the results of location specific data from a number of sources and is illustrated in a flow cytometry application.

摘要翻译： 计算机上的图形用户界面提供对位置特定数据的分析和分析结果的呈现，以供用户视觉比较。 分析结果以视觉方式呈现为按区域划分的图标，并以这样一种方式排列，使得用户能够将每个图标与数据位置相关联。 在图标和区域中的视觉呈现结果允许用户根据位置在两个或多个数据集中视觉比较分析结果。 图形用户界面还通过用户与分析的图形表示的交互来进一步提供对分析的定义和调整。 在某些情况下，结果的视觉呈现跟踪分析调整，以便用户可以直观地观察调整对结果的影响。 描述了与接口交互以定义分析并表示结果的方法以及使用该接口呈现两个或多个数据集的方法。 界面可用于分析和视觉比较来自多个来源的位置特定数据的结果，并在流式细胞术应用中进行了说明。

公开(公告)号：US08885153B2

公开(公告)日：2014-11-11

申请号：US13461713

申请日：2012-05-01

申请人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

发明人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

IPC分类号： G01N15/14

CPC分类号： G01N15/14 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.

摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。

公开(公告)号：US07847923B2

公开(公告)日：2010-12-07

申请号：US11862680

申请日：2007-09-27

申请人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

发明人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

IPC分类号： G01P3/36

CPC分类号： G01N15/14 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.

摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。

公开(公告)号：US20110063602A1

公开(公告)日：2011-03-17

申请号：US12951911

申请日：2010-11-22

申请人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

发明人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

IPC分类号： G01P3/36

CPC分类号： G01N15/14 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.

摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。

公开(公告)号：US20080221812A1

公开(公告)日：2008-09-11

申请号：US11862680

申请日：2007-09-27

申请人： Richard PITTARO ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

发明人： Richard PITTARO ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

IPC分类号： G06F19/00 ,  G01N21/00

CPC分类号： G01N15/14 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.

摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。

公开(公告)号：US20120236291A1

公开(公告)日：2012-09-20

申请号：US13461713

申请日：2012-05-01

申请人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

发明人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

IPC分类号： G01P3/36

CPC分类号： G01N15/14 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.

摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。

公开(公告)号：US08184271B2

公开(公告)日：2012-05-22

申请号：US12951911

申请日：2010-11-22

申请人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A King

发明人： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A King

IPC分类号： G01P3/36

CPC分类号： G01N15/14 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.

摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。