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公开(公告)号：US20110063602A1
公开(公告)日：2011-03-17
申请号：US12951911
申请日：2010-11-22
申请人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
发明人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
IPC分类号： G01P3/36
CPC分类号： G01N15/14 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1477 , G01N2015/1486
摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.
摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。
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公开(公告)号：US20080221812A1
公开(公告)日：2008-09-11
申请号：US11862680
申请日：2007-09-27
申请人： Richard PITTARO , Bruce Goldman , Ray Lefebvre , David A. King
发明人： Richard PITTARO , Bruce Goldman , Ray Lefebvre , David A. King
CPC分类号： G01N15/14 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1477 , G01N2015/1486
摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.
摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。
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公开(公告)号：US20060105461A1
公开(公告)日：2006-05-18
申请号：US10971966
申请日：2004-10-22
申请人： May Tom-Moy , Reid Brennen , Arthur Schleifer , Hongfeng Yin , Tom Goor , James Young , Richard Pittaro
发明人： May Tom-Moy , Reid Brennen , Arthur Schleifer , Hongfeng Yin , Tom Goor , James Young , Richard Pittaro
IPC分类号： G01N35/00
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6825 , C12Q1/6869 , Y10T436/11 , C12Q2565/631
摘要： Nanopore analysis systems, methods of preparing nanopore analysis systems, and methods of automating the analysis of samples using nanopore analysis systems, are provided.
摘要翻译： 提供纳米孔分析系统，制备纳米孔分析系统的方法以及使用纳米孔分析系统自动分析样品的方法。
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公开(公告)号：US20060068401A1
公开(公告)日：2006-03-30
申请号：US10957378
申请日：2004-09-30
申请人： Curt Flory , Richard Pittaro , Phillip Barth
发明人： Curt Flory , Richard Pittaro , Phillip Barth
CPC分类号： G01N33/48721 , B82Y10/00 , B82Y15/00 , G01N15/1031
摘要： The invention provides an apparatus and method for sequencing and identifying a biopolymer. The invention provides a first electrode, a second electrode, a first gate electrode, a second gate electrode, a gate voltage source and a potential means. The gate electrodes may be ramped by a voltage source to search and determine a resonance level between the first electrode, biopolymer and second electrode. The potential means that is in electrical connection with the first electrode and the second electrode is maintained at a fixed voltage. A method of biopolymer sequencing and identification is also disclosed.
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公开(公告)号：US08885153B2
公开(公告)日：2014-11-11
申请号：US13461713
申请日：2012-05-01
申请人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
发明人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
IPC分类号： G01N15/14
CPC分类号： G01N15/14 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1477 , G01N2015/1486
摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.
摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。
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公开(公告)号：US20120236291A1
公开(公告)日：2012-09-20
申请号：US13461713
申请日：2012-05-01
申请人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
发明人： Richard Pittaro , Bruce Goldman , Ray Lefebvre , David A. King
IPC分类号： G01P3/36
CPC分类号： G01N15/14 , G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1477 , G01N2015/1486
摘要： A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.
摘要翻译： 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。
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公开(公告)号：US20060071209A1
公开(公告)日：2006-04-06
申请号：US10996846
申请日：2004-11-23
申请人： Curt Flory , Richard Pittaro , Phillip Barth
发明人： Curt Flory , Richard Pittaro , Phillip Barth
CPC分类号： G01N33/48721 , B82Y5/00 , B82Y10/00 , B82Y15/00 , C12Q1/6869 , G01N15/1031 , C12Q2565/631
摘要： The invention provides an apparatus and method for sequencing and identifying a biopolymer. The invention provides a first electrode, a second electrode, a first gate electrode, a second gate electrode, a gate voltage source and a potential means. The gate electrodes may be ramped by a voltage source to search and determine a resonance level between the first electrode, biopolymer and second electrode. The potential means that is in electrical connection with the first electrode and the second electrode is maintained at a fixed voltage. A method of biopolymer sequencing and identification is also disclosed.
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公开(公告)号：US20050136416A1
公开(公告)日：2005-06-23
申请号：US10747004
申请日：2003-12-23
CPC分类号： G01N33/6893 , C12Q1/6837 , G01N33/5091 , C12Q2565/515
摘要： Patient specific array-based assays are provided. A feature of the subject patient specific array-based assays is that they include a step of interrogating a set of array features that have been previously identified by a general array-based assay to be relevant to a specific disease and condition of the subject being assayed. Also provided are methods of producing the subject patient specific array-based assays, as well as compositions and kits for use in practicing the subject assays.
摘要翻译： 提供了基于特定阵列的测定法。 基于患者特异性基于阵列的测定的特征在于它们包括询问一组阵列特征的步骤，其先前已经通过基于阵列的测定法被识别为与被测定的受试者的特定疾病和状况相关 。 还提供了产生基于患者特异性阵列的测定法的方法，以及用于实践受试者测定的组合物和试剂盒。
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9.发明申请公开(公告)号：US20050126905A1
公开(公告)日：2005-06-16
申请号：US10960176
申请日：2004-10-07
申请人： Jene Golovchenko , Derek Stein , George Yefchak , Richard Pittaro , Curt Flory
发明人： Jene Golovchenko , Derek Stein , George Yefchak , Richard Pittaro , Curt Flory
CPC分类号： G01N33/48721 , B01L3/5027 , B24B37/013 , B81C99/004 , B81C99/0065 , H01L22/26 , H01L2924/0002 , H01L2924/00
摘要： The invention provides a method for controlled fabrication of a solid state structural feature. In the method, a solid state structure is provided and the structure is exposed to an ion beam, under fabrication process conditions for producing the structural feature. A physical detection species is directed toward a designated structure location, and the rate at which the detection species proceeds from the designated structure location is measured. Detection species rate measurements are fit to a mathematical model, and the fabrication process conditions are controlled, based on the fitted detection species rate measurements, to fabricate the structural feature.
摘要翻译： 本发明提供了一种用于控制制造固态结构特征的方法。 在该方法中，在用于产生结构特征的制造工艺条件下，提供固态结构并且将结构暴露于离子束。 物理检测物质指向指定的结构位置，并且测量检测物种从指定的结构位置进行的速率。 检测物种率测量符合数学模型，并且基于拟合的检测物种速率测量来控制制造工艺条件以制造结构特征。
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10.发明申请公开(公告)号：US20050095599A1
公开(公告)日：2005-05-05
申请号：US10699478
申请日：2003-10-30
申请人： Richard Pittaro , Edward Verdonk , Thomas Doherty
发明人： Richard Pittaro , Edward Verdonk , Thomas Doherty
CPC分类号： G01N21/6428 , B01L3/5027 , B82Y15/00 , G01N33/48721 , G01N33/542 , G01N33/6803 , G01N2021/6432
摘要： The present invention provides an apparatus for detecting a nanoscale moiety and a method for sensing a nanoscale moiety. The apparatus includes a substrate having a nanopore, at least one excitable molecule attached to the substrate adjacent to the nanopore, and a light source for exciting the excitable molecule attached to the substrate adjacent to the nanopore wherein the excitable molecule is quenched by the quencher molecule on the nanoscale moiety as it passes by the excitable molecule. The invention also includes a method for detecting the presence or identity of the nanoscale moiety.
摘要翻译： 本发明提供了一种用于检测纳米尺度部分的装置和用于感测纳米尺度部分的方法。 该装置包括具有纳米孔的底物，与纳米孔相邻的至少一个可附着到基底上的可激发分子，以及用于激发附着于邻近纳米孔的底物的可激发分子的光源，其中可激发分子被猝灭剂分子淬灭 在纳米级部分通过可兴奋分子时。 本发明还包括用于检测纳米尺度部分的存在或身份的方法。
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