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公开(公告)号：US20070099252A1
公开(公告)日：2007-05-03
申请号：US11585030
申请日：2006-10-23
申请人： Ameesha Batheja , George Ho , Michael D'Andrea , David Uhlinger
发明人： Ameesha Batheja , George Ho , Michael D'Andrea , David Uhlinger
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： C07K16/18 , C07K14/4702 , G01N33/574 , G01N33/57407 , G01N33/57415 , G01N33/57484 , G01N33/57496 , G01N33/6863 , G01N2333/4703 , G01N2500/00
摘要： The present invention provides nucleic acids. Polypeptides, antibodies and cells related to MAIL (Molecule possessing Ankyrin repeats Induced by LPS; or IκB-ζ), a novel member of the IκB family, expressed in LPS stimulated monocytes and uses thereof. The isolated nucleic acids, polypeptides, antibodies and cells of the invention can be used in detection assays, screening methods and drug discovery assays.
摘要翻译： 本发明提供核酸。 与LPS相关的多肽，抗体和细胞（由LPS诱导的锚蛋白重复的分子;或IkappaB-zeta），IkappaB家族的新成员，以LPS刺激的单核细胞及其用途表达。 本发明的分离的核酸，多肽，抗体和细胞可用于检测测定，筛选方法和药物发现测定。
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公开(公告)号：US07432343B2
公开(公告)日：2008-10-07
申请号：US11585030
申请日：2006-10-23
CPC分类号： C07K16/18 , C07K14/4702 , G01N33/574 , G01N33/57407 , G01N33/57415 , G01N33/57484 , G01N33/57496 , G01N33/6863 , G01N2333/4703 , G01N2500/00
摘要： The present invention provides nucleic acids. Polypeptides, antibodies and cells related to MAIL (Molecule possessing Ankyrin repeats Induced by LPS; or IκB-ζ), a novel member of the IκB family, expressed in LPS stimulated monocytes and uses thereof. The isolated nucleic acids, polypeptides, antibodies and cells of the invention can be used in detection assays, screening methods and drug discovery assays.
摘要翻译： 本发明提供核酸。 与LPS相关的多肽，抗体和细胞（由LPS诱导的锚蛋白重复的分子;或IkappaB-zeta），IkappaB家族的新成员，以LPS刺激的单核细胞及其用途表达。 本发明的分离的核酸，多肽，抗体和细胞可用于检测测定，筛选方法和药物发现测定。
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公开(公告)号：US07063953B2
公开(公告)日：2006-06-20
申请号：US10401916
申请日：2003-03-28
申请人： Ning Qin , Ellen Codd , Michael D'Andrea
发明人： Ning Qin , Ellen Codd , Michael D'Andrea
IPC分类号： G01N33/567
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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公开(公告)号：US20100003712A1
公开(公告)日：2010-01-07
申请号：US12474413
申请日：2009-05-29
IPC分类号： C12Q1/02 , C07K14/715
CPC分类号： C12Q1/37 , G01N33/6869 , G01N2333/9648 , G01N2500/10
摘要： A biomarker that correlates to treatment with drugs that inhibit chymase is disclosed. This biomarker has been shown to have utility in assessing response to chymase inhibitor compounds. The immunoreactivity or levels of the biomarker is increased upon treatment with chymase inhibitor compounds, thus indicating that this biomarker is involved in chymase activity.
摘要翻译： 公开了与用抑制胃促胰酶的药物治疗相关的生物标志物。 该生物标志物已被证明可用于评估对胃促胰酶抑制剂化合物的反应。 在用糜酶抑制剂化合物治疗时，生物标志物的免疫反应性或水平增加，因此表明该生物标志物参与糜酶活性。
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公开(公告)号：US20070166779A1
公开(公告)日：2007-07-19
申请号：US11652753
申请日：2007-01-12
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N2333/811
摘要： It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a human subject by measuring SLPI processing, as well as other related methods and compositions.
摘要翻译： 现在发现人糜酶在特定位点切割人SLPI，并且该切割可以用作糜酶活性的指示剂。 本发明提供了通过测量SLPI处理以及其它相关方法和组合物来诊断糜酶相关疾病或通过测量人受试者中糜酶相关疾病的治疗效率的方法。
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公开(公告)号：US06994993B2
公开(公告)日：2006-02-07
申请号：US09875456
申请日：2001-06-06
申请人： Ning Qin , Ellen Codd , Michael D'Andrea
发明人： Ning Qin , Ellen Codd , Michael D'Andrea
IPC分类号： C12N15/12
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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7.发明申请公开(公告)号：US20050227297A1
公开(公告)日：2005-10-13
申请号：US11100656
申请日：2005-04-07
申请人： Michael D'Andrea
发明人： Michael D'Andrea
IPC分类号： G01N33/53 , G01N33/554 , G01N33/567 , G01N33/569 , G01N33/68
CPC分类号： G01N33/6887 , G01N33/68 , G01N2333/78 , G01N2333/96486
摘要： Pretreating a tissue sample with an effective amount of collagenase results in increased immunodetection of collagen and enhanced preservation of tissue morphology. Such an improved method for immunodetection of collagen can be used in immunohistochemical studies of formalin-fixed, paraffin-embedded tissue sections.
摘要翻译： 用有效量的胶原酶预处理组织样品导致增加的胶原免疫检测和增强组织形态的保存。 这种改进的胶原免疫检测方法可用于福尔马林固定的石蜡包埋组织切片的免疫组织化学研究。
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公开(公告)号：US07408036B2
公开(公告)日：2008-08-05
申请号：US11370490
申请日：2006-03-08
申请人： Ning Qin , Ellen Codd , Michael D'Andrea
发明人： Ning Qin , Ellen Codd , Michael D'Andrea
IPC分类号： C07K14/705
CPC分类号： C07K16/2803 , C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 编码人电压门控钠通道β1A亚基的DNA已被克隆和表征。 重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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9.发明申请Immunoglobulin-positive neurons in Alzheimer disease are dying via the classical, antibody-dependent, complement pathway 审中-公开阿尔茨海默病中的免疫球蛋白阳性神经元通过经典的抗体依赖性补体途径死亡公开(公告)号：US20060024753A1
公开(公告)日：2006-02-02
申请号：US11188479
申请日：2005-07-25
申请人： Michael D'Andrea
发明人： Michael D'Andrea
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： Ig-positive neurons, which have been shown to be present in Alzheimer's disease, are shown to have complement C1q and C5b-9 proteins. C1q and C5b-9 can be employed in diagnosis and treatment of Alzheimer's disease.
摘要翻译： 显示存在于阿尔茨海默氏病中的Ig阳性神经元显示具有补体C1q和C5b-9蛋白。 C1q和C5b-9可用于阿尔茨海默病的诊断和治疗。
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