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公开(公告)号:US20070221437A1
公开(公告)日:2007-09-27
申请号:US11714510
申请日:2007-03-06
申请人: Anders Kryhlmand , Ove Pedersen , Niels Hansen , Poul Ennemark
发明人: Anders Kryhlmand , Ove Pedersen , Niels Hansen , Poul Ennemark
IPC分类号: B62D5/08
摘要: The invention concerns a hydraulic steering (1) with a steering valve (7) located between a supply connection arrangement (P, T) and a steering motor (2). It is endeavoured to improve the safety of such a steering. For this purpose, the steering valve (7) has a hydraulic drive (9, 10) with a pilot valve arrangement (11) supplied by a pressure control valve (5), a stop valve (16) being located between the pressure control valve (5) and the pilot valve arrangement (11).
摘要翻译: 本发明涉及一种具有位于供应连接装置(P,T)和转向马达(2)之间的转向阀(7)的液压转向装置(1)。 我们努力提高这种转向的安全性。 为此,转向阀(7)具有带有由压力控制阀(5)供给的先导阀装置(11)的液压驱动装置(9,10),一个位于压力控制阀 (5)和先导阀装置(11)。
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公开(公告)号:US07997379B2
公开(公告)日:2011-08-16
申请号:US11714510
申请日:2007-03-06
IPC分类号: B62D5/06
摘要: The invention concerns a hydraulic steering (1) with a steering valve (7) located between a supply connection arrangement (P, T) and a steering motor (2). It is endeavored to improve the safety of such a steering. For this purpose, the steering valve (7) has a hydraulic drive (9, 10) with a pilot valve arrangement (11) supplied by a pressure control valve (5), a stop valve (16) being located between the pressure control valve (5) and the pilot valve arrangement (11).
摘要翻译: 本发明涉及一种具有位于供应连接装置(P,T)和转向马达(2)之间的转向阀(7)的液压转向装置(1)。 我们努力提高这种转向的安全性。 为此,转向阀(7)具有带有由压力控制阀(5)供给的先导阀装置(11)的液压驱动装置(9,10),一个位于压力控制阀 (5)和先导阀装置(11)。
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公开(公告)号:US20070221435A1
公开(公告)日:2007-09-27
申请号:US11714364
申请日:2007-03-06
申请人: Jan Vernersen , Ove Pedersen , Niels Hansen
发明人: Jan Vernersen , Ove Pedersen , Niels Hansen
IPC分类号: B62D5/08
摘要: The invention concerns a hydraulic steering (1) with a steering motor (8), a steering unit (2) with feedback behaviour, a steering member activating the steering unit (2) and a shock valve arrangement (50) between the steering motor (8) and the steering unit (2). It is endeavoured to enable changes of the feedback behaviour in a simple manner. For this purpose it is ensured that a switchable feedback suppression device (9) is located at the side of the shock valve arrangement (50) facing away from the steering motor (8).
摘要翻译: 本发明涉及具有转向电动机(8)的液压转向(1),具有反馈特性的转向单元(2),启动转向单元(2)的转向构件和转向电动机之间的冲击阀装置(50) 8)和转向单元(2)。 努力以简单的方式来改变反馈行为。 为此目的,确保可切换反馈抑制装置(9)位于远离转向马达(8)的冲击阀装置(50)侧。
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公开(公告)号:US06417393B1
公开(公告)日:2002-07-09
申请号:US09194083
申请日:1999-01-22
申请人: Palle Christophersen , Ove Pedersen
发明人: Palle Christophersen , Ove Pedersen
IPC分类号: C07C24100
CPC分类号: C07C311/47 , A61K31/155 , A61K31/17 , C07C233/55 , C07C271/58 , C07C275/40 , C07C275/42 , C07C309/51 , C07C311/08 , C07C311/21 , C07C311/60 , C07C335/22
摘要: The present patent application relates to compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein one of R1, R2 and R3 is a non-cyclic acidic group having a pKa value below 8 or a group which is in vivo convertible to such a group; R4, R5 and the other two of the substituents R1, R2 and R3 are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amnino, and aryl, aralkyl, arylamino, aryloxy, aryl—CO—, or heteroaryl, wherein the aryl and heteroaryl groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or R3 and R4 or R4 and R5 together form a fused 4- to 7-membered carbocyclic ring which may be unsaturated, or partially or fully saturated, while the other substituents R1, R2, R3, R4 and R5 are as defined above; Y is —CO—, —CS—, —SO2—, or —C(═N—R8)—, wherein R8 is hydrogen, alkyl, or cyano; X is —NH—, —CH2—NH—, or —SO2—NH—; Z is NR6, O, —CH═CH—, —C═C—, —N═CH—, or —CH═N—; wherein R6 is hydrogen, or alkyl; R11, R12, R13, R14 and R15 are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, —NHSO2—R7, —COOR7, —SO2N(R7)2, —SO2OR7 and —CO—R7, wherein R7 is hydrogen alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl or aralkyl; and aryl, aralkyl, arylamino, aryloxy, aryl-CO—, or heteroaryl, wherein the aryl and heteroaryl groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or one of R11 and R12, R12 and R13, R13 and R14 or R14 and R15 together form a fused 4- to 7-membered carbocyclic ring which may be unsaturated, or partially or fully saturated, while the other substituents R11, R12, R13, R14 and R15 are as defined above. The compounds are useful for the treatment of diseases and disorders responsive to the blockage of chloride channels.
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公开(公告)号:US20060269576A1
公开(公告)日:2006-11-30
申请号:US11140457
申请日:2005-05-27
申请人: Peter Moldt , Ove Pedersen , Klaus Theobald , Michael Flanagan
发明人: Peter Moldt , Ove Pedersen , Klaus Theobald , Michael Flanagan
CPC分类号: A61K39/35 , A61K39/36 , A61K2039/54
摘要: Methods and compositions are disclosed for the reduction of immune responses to an exogenous allergen. The reduction is obtained by pre-treatment or pre-conditioning, without injection, of a subject with the allergen so as to reduce immune responses in the subject upon additional exposure to the allergen. The invention is advantageously used in a variety of contexts, including seasonal allergies wherein pre-treatment or pre-conditioning is performed before the onset of the seasonal allergy.
摘要翻译: 公开了减少对外源性变应原的免疫应答的方法和组合物。 通过预处理或预处理而不注射受试者与变应原来获得还原,以便在额外暴露于变应原时降低受试者的免疫应答。 本发明有利地用于各种情况,包括在季节性变态反应发作之前进行预处理或预处理的季节性过敏。
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公开(公告)号:US20090214597A1
公开(公告)日:2009-08-27
申请号:US11915564
申请日:2006-05-19
申请人: Peter Moldt , Ove Pedersen , Klaus Theobald , Michael Flanagan
发明人: Peter Moldt , Ove Pedersen , Klaus Theobald , Michael Flanagan
CPC分类号: A61K39/35 , A61K39/36 , A61K2039/54
摘要: Methods and compositions are disclosed for the reduction of immune responses to an exogenous allergen. The reduction is obtained by pre-treatment or pre-conditioning, without injection, of a subject with the allergen so as to reduce immune responses in the subject upon additional exposure to the allergen. The invention is advantageously used in a variety of contexts, including seasonal allergies wherein pre-treatment or pre-conditioning is performed before the onset of the seasonal allergy.
摘要翻译: 公开了减少对外源性变应原的免疫应答的方法和组合物。 通过预处理或预处理而不注射受试者与变应原来获得还原,以便在额外暴露于变应原时降低受试者的免疫应答。 本发明有利地用于各种情况,包括在季节性变态反应发作之前进行预处理或预处理的季节性过敏。
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公开(公告)号:US5696138A
公开(公告)日:1997-12-09
申请号:US535267
申请日:1995-12-27
IPC分类号: A61K31/165 , A61K31/17 , A61K31/195 , A61K31/24 , A61K31/44 , A61P1/00 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/18 , A61P43/00 , C07C231/02 , C07C233/29 , C07C235/38 , C07C273/18 , C07C275/30 , C07C275/32 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C277/08 , C07C279/18 , C07C335/16 , C07C335/18 , C07D213/75 , C07D213/36
CPC分类号: C07D213/75 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/24 , A61K31/44 , C07C233/29 , C07C235/38 , C07C275/30 , C07C275/32 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C279/18 , C07C335/18
摘要: A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein X, Z, Y, A, D, E, F, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.11, R.sup.12 have the meanings set forth in the specification, pharmaceutical compositions comprising the same, and a method of treating therewith. The compounds are useful as potassium channel openers.
摘要翻译: PCT No.PCT / EP94 / 01008 Sec。 371 1995年12月27日第 102(e)日期1995年12月27日PCT 1994年3月30日PCT PCT。 第WO94 / 22807号公报 日期:1994年10月13日具有式“IMAGE”的化合物或其药学上可接受的盐,其中X,Z,Y,A,D,E,F,R 1,R 2,R 3,R 4,R 11, 在说明书中,含有该组合物的药物组合物及其处理方法。 这些化合物可用作钾通道开放剂。
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公开(公告)号:US06971472B2
公开(公告)日:2005-12-06
申请号:US10727905
申请日:2003-12-04
申请人: Ove Pedersen , Bjarne Schmidt
发明人: Ove Pedersen , Bjarne Schmidt
摘要: The invention concerns a fully hydraulic steering with a steering member, a steering unit that can be activated by the steering member, said steering unit comprising a supply connection arrangement (P, T) with a pressure connection (P) and a tank connection (T), and a working connection arrangement (L, R) with two working connections (L, R), and a steering motor, which is connected with the working connection arrangement (L, R). It is endeavored to increase the possibilities of steering. For this purpose, it is ensured that an auxiliary force operated steering valve is arranged in parallel to the steering unit between the supply connection arrangement (P, T) and the working connection arrangement (L, R).
摘要翻译: 本发明涉及一种具有转向构件的全液压转向装置,一种可由转向构件启动的转向装置,所述转向装置包括具有压力连接(P)和油箱连接(T)的供应连接装置(P,T) )和与工作连接装置(L,R)连接的具有两个工作连接(L,R)和转向马达的工作连接装置(L,R)。 努力提高转向的可能性。 为此,确保辅助力操作转向阀与供给连接装置(P,T)和工作连接装置(L,R)之间的转向单元平行布置。
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9.
公开(公告)号:US5763406A
公开(公告)日:1998-06-09
申请号:US481840
申请日:1995-06-07
申请人: Ove Pedersen , D. K. MacFadden
发明人: Ove Pedersen , D. K. MacFadden
IPC分类号: A61K38/00 , A61K38/16 , A61P31/12 , A61P31/22 , C07K5/10 , C07K5/12 , C07K7/06 , C07K7/54 , C07K7/64 , C07K14/16 , A61K38/08 , A61K38/12
CPC分类号: C07K7/06 , A61K38/162 , C07K14/005 , C12N2740/16122
摘要: Peptides of the general formula (I): I-A-B-C-D-E-F-G-H-II are disclosed as being active against Herpes virus infections in animals and human beings, wherein A is Ala, Gly, Val or absent; B is Ala, Gly, Val, Ser or absent; C is Ser, Thr or absent; D is Ser, Thr, Ans, Glu, Arg, Ile, Leu or absent; E is Ser, Thr, Asp or absent; F is Thr, Ser, Asn, Gln, Lys, Trp or absent; G is Tyr or absent; H is Thr, Gly, Met, Met(O), Cys, Thr or Gly; I is Cys or absent, and II is Cys, an amide group, substituted amide group, an ester group or absent, wherein the peptides comprise at least 4 amino acids and physiologically acceptable salts thereof.
摘要翻译: 公开了通式(I):I-A-B-C-D-E-F-G-H-II的肽对动物和人类中的疱疹病毒感染具有活性,其中A是Ala,Gly,Val或不存在; B是Ala,Gly,Val,Ser或不存在; C是Ser,Thr或不存在; D是Ser,Thr,Ans,Glu,Arg,Ile,Leu或不存在; E是Ser,Thr,Asp或不存在; F是Thr,Ser,Asn,Gln,Lys,Trp或不存在; G是Tyr或不存在; H是Thr,Gly,Met,Met(O),Cys,Thr或Gly; I是Cys或不存在,II是Cys,酰胺基,取代的酰胺基,酯基或不存在,其中肽包含至少4个氨基酸及其生理上可接受的盐。
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公开(公告)号:US09038762B2
公开(公告)日:2015-05-26
申请号:US11714364
申请日:2007-03-06
申请人: Jan Vernersen , Ove Pedersen , Niels Bjarne Hansen
发明人: Jan Vernersen , Ove Pedersen , Niels Bjarne Hansen
摘要: The invention concerns a hydraulic steering (1) with a steering motor (8), a steering unit (2) with feedback behavior, a steering member activating the steering unit (2) and a shock valve arrangement (50) between the steering motor (8) and the steering unit (2). It is endeavored to enable changes of the feedback behavior in a simple manner. For this purpose it is ensured that a switchable feedback suppression device (9) is located at the side of the shock valve arrangement (50) facing away from the steering motor (8).
摘要翻译: 本发明涉及具有转向电动机(8)的液压转向(1),具有反馈特性的转向单元(2),启动转向单元(2)的转向构件和转向电动机之间的冲击阀装置(50) 8)和转向单元(2)。 努力以简单的方式来改变反馈行为。 为此目的,确保可切换反馈抑制装置(9)位于远离转向马达(8)的冲击阀装置(50)侧。
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