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14 条记录 (耗时 0.023 秒)

    Process for the preparation of alpha-aryl-propionic acids and alkaline salts thereof
    7.
    发明授权
    Process for the preparation of alpha-aryl-propionic acids and alkaline salts thereof 失效
    制备α-芳基丙酸及其碱式盐的方法

    公开(公告)号：US4536595A

    公开(公告)日：1985-08-20

    申请号：US419616

    申请日：1982-09-17

    申请人： Andrea Gardano ,  Franco Francalcanci ,  Marco Foa

    发明人： Andrea Gardano ,  Franco Francalcanci ,  Marco Foa

    IPC分类号： C07C57/30 ,  B01J31/00 ,  C07B61/00 ,  C07C51/00 ,  C07C51/10 ,  C07C59/64 ,  C07C67/00

    CPC分类号： C07C51/10

    摘要： Alpha-arylpropionic acids and alkaline salts thereof are prepared by catalytic reaction with carbon monoxide of the corresponding secondary halids in an anhydrous low alcohol solvent in the presence of a salt of cobalt hydrocarbonyl and in further presence of alkaline hydroxides under substantially ambient temperature and pressure conditions.The products obtained find useful applications in the field of pharmaceutics (analgesics, antipyretics, etc.) and as intermediates for chemical syntheses of fine chemicals, phytodrugs, etc.

    摘要翻译： α-芳基丙酸及其碱性盐通过在无水低醇溶剂中在钴盐基的存在下和在碱性氢氧化物的存在下在基本环境温度和压力条件下与相应的二级卤化物的一氧化碳进行催化反应来制备 。 所得产品在制药领域（镇痛药，解热药剂等）和精细化学品，植物药物等的化学合成中间体有用。

    Preparing carboxylic acids or esters by oxidative cleavage of unsaturated fatty acids or esters
    9.
    发明授权
    Preparing carboxylic acids or esters by oxidative cleavage of unsaturated fatty acids or esters 失效
    通过不饱和脂肪酸或酯的氧化裂解制备羧酸或酯

    公开(公告)号：US5336793A

    公开(公告)日：1994-08-09

    申请号：US988671

    申请日：1992-12-10

    申请人： Andrea Gardano ,  Giampiero Sabarino ,  Marco Foa

    发明人： Andrea Gardano ,  Giampiero Sabarino ,  Marco Foa

    IPC分类号： B01J31/34 ,  C07C51/285 ,  C07C53/126 ,  C07C55/18 ,  C07C67/333 ,  C07C69/24 ,  C07C69/48 ,  C07D20060101 ,  C11C1/00 ,  C07C51/25 ,  C07C67/00

    CPC分类号： C07C51/285 ,  C07C67/333

    摘要： A method of preparing carboxylic acids or esters thereof by the oxidative cleavage of unsaturated fatty acids or esters thereof is carried out in a two-phase aqueous-organic system in which the organic phase contains the unsaturated fatty acid and/or the esters thereof and the aqueous phase contains hydrogen peroxide. The oxidative cleavage is carried out in the presence of a catalytic system including a catalyst belonging to the group constituted by tungstic and molybdic acids and alkaline salts thereof, and an onium salt which acts as a phase-transfer agent for the catalyst, and has the formula:(R.sub.2 R.sub.3 R.sub.4 R.sub.5 M).sup.+ Y.sup.-in which R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent hydrocarbon groups of which at least one must have more than 10 carbon atoms,M is N or P, andY.sup.- is an inorganic anion.

    摘要翻译： 通过不饱和脂肪酸或其酯的氧化裂解制备羧酸或其酯的方法是在有机相含有不饱和脂肪酸和/或其酯的两相水 - 有机体系中进行的， 水相含有过氧化氢。 氧化裂解在催化体系存在下进行，催化体系包括属于由钨酸和钼酸及其碱式盐构成的组的催化剂，以及作为催化剂的相转移剂的鎓盐， 式（R 2 R 3 R 4 R 5 M）+ Y-，其中R 2，R 3，R 4和R 5表示至少必须具有多于10个碳原子的烃基，M是N或P，Y-是无机阴离子。

    Process for the preparation of carboxylic acids from organic halides
    10.
    发明授权
    Process for the preparation of carboxylic acids from organic halides 失效
    从有机卤化物制备羧酸的方法

    公开(公告)号：US4034004A

    公开(公告)日：1977-07-05

    申请号：US585756

    申请日：1975-06-10

    申请人： Luigi Cassar ,  Marco Foa ,  Andrea Gardano

    发明人： Luigi Cassar ,  Marco Foa ,  Andrea Gardano

    IPC分类号： C07C53/00 ,  B01J31/00 ,  B01J31/24 ,  C07B61/00 ,  C07C51/00 ,  C07C51/10 ,  C07C51/145 ,  C07C53/126 ,  C07C57/32 ,  C07C57/44 ,  C07C63/00 ,  C07C63/06 ,  C07C63/10 ,  C07C67/00

    CPC分类号： B01J31/2404 ,  B01J31/0239 ,  B01J31/0267 ,  B01J31/24 ,  B01J31/2409 ,  C07C51/10 ,  C07C51/145 ,  B01J2231/34 ,  B01J2531/824 ,  B01J2531/96 ,  B01J31/2295

    摘要： A process for preparing carboxylic acids by reaction of carbon monoxide with aromatic and aliphatic organic halides, optionally further substituted by groups inert under the reaction conditions, and catalyzed by phosphinic palladium complexes and in the presence of quaternary alkyl-ammonium salts, characterized in that said process is conducted in a double liquid phase consisting essentially of (a) the organic halide and the catalytic palladium complex or their solutions in at least one hydrocarbon solvent immiscible with H.sub.2 O, and (b) an aqueous inorganic alkaline solution containing the quaternary alkyl-ammonium salt, at a temperature between about 50.degree. and 150.degree. C. More particularly, the reaction is conducted in the presence of at least one catalyst selected from among:A. at least one palladium complex of the formula:Pd[P(R).sub.3 ].sub.mwherein m is a whole number from 2 to 4, and (R).sub.3 represents a homogeneous or a heterogeneous group consisting of phenyl and/or alkyl radicals which may also be further substituted by inert groups;B. at least one palladium complex of the general formula:Pd[P(R).sub.2 -- (CH.sub.2).sub.n -- P(R).sub.2 ].sub.pwherein (R).sub.2 has the same meaning indicated above for (R).sub.3, p is a whole number from 1 to 2, and n is a whole number from 1 to 6; orC. at least one palladium complex of the general formula: ##STR1## wherein the groups (R).sub.3, equal to or different from each other, have the same meaning as indicated above, and Y is a halogen atom and/or an aryl radical.

    摘要翻译： 通过一氧化碳与芳族和脂肪族有机卤化物的反应制备羧酸的方法，任选进一步被反应条件下惰性的基团取代，并通过次膦酸钯络合物和季烷基铵盐的存在进行催化，其特征在于所述 方法在基本上由（a）有机卤化物和催化钯络合物或它们的溶液在至少一种与H 2 O不混溶的烃溶剂中组成的双液相中进行，和（b）含有季烷基铵的含水无机碱溶液 盐，在约50℃至150℃的温度下进行。更具体地说，反应在至少一种选自以下的催化剂存在下进行：