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公开(公告)号：US06358504B1
公开(公告)日：2002-03-19
申请号：US08796336
申请日：1997-02-07
申请人： Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , Koc-Kan Ho , David Gschneidner
发明人： Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , Koc-Kan Ho , David Gschneidner
IPC分类号： A61K3800
CPC分类号： C07D209/48 , A61K9/1617 , A61K31/195 , A61K31/445 , A61K31/4965 , A61K31/727 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K45/06 , C07C229/42 , C07C233/51 , C07C233/54 , C07C233/69 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30 , A61K2300/00
摘要： Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译： 提供了可用于递送活性剂的载体化合物及其组合物。 也提供给药和制备方法。
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公开(公告)号：US07125910B2
公开(公告)日：2006-10-24
申请号：US10373582
申请日：2003-02-24
申请人： Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , David Gschneidner , Koc-Kan Ho
发明人： Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , David Gschneidner , Koc-Kan Ho
IPC分类号： A61K31/192 , C07C229/34
CPC分类号： C07D209/48 , A61K9/1617 , A61K31/195 , A61K31/445 , A61K31/4965 , A61K31/727 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K45/06 , C07C229/42 , C07C233/51 , C07C233/54 , C07C233/69 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30 , A61K2300/00
摘要： Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号：US06525020B2
公开(公告)日：2003-02-25
申请号：US10001731
申请日：2001-10-31
申请人： Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , Koc-Kan Ho , David Gschneidner
发明人： Andrea Leone-Bay , Eric Wang , Donald J. Sarubbi , Harry Leipold , Koc-Kan Ho , David Gschneidner
IPC分类号： A61K3800
CPC分类号： C07D209/48 , A61K9/1617 , A61K31/195 , A61K31/445 , A61K31/4965 , A61K31/727 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K45/06 , C07C229/42 , C07C233/51 , C07C233/54 , C07C233/69 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30 , A61K2300/00
摘要： Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号：US5863944A
公开(公告)日：1999-01-26
申请号：US846254
申请日：1997-04-30
IPC分类号： A61K9/00 , A61K9/08 , A61K9/20 , A61K9/48 , A61K38/00 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/24 , A61K38/27 , A61K38/28 , A61K39/395 , A61K45/00 , A61K47/04 , A61K47/10 , A61K47/16 , A61K47/18 , C07C233/25 , C07C237/36 , C07C237/40 , A01N37/00 , A01N37/12 , C07C229/00
CPC分类号： A61K47/183 , A61K47/18 , A61K9/0053 , C07C233/25 , C07C237/36 , C07C237/40
摘要： Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号：US06693073B2
公开(公告)日：2004-02-17
申请号：US10172582
申请日：2002-06-14
申请人： Sam J. Milstein , John E. Smart , Donald J. Sarubbi , Monica Leipold , Elizabeth Flanders , Doris O'Toole , Andrea Leone-Bay , David Gschneidner
发明人： Sam J. Milstein , John E. Smart , Donald J. Sarubbi , Monica Leipold , Elizabeth Flanders , Doris O'Toole , Andrea Leone-Bay , David Gschneidner
IPC分类号： A61K3828
CPC分类号： C07C235/64 , A61K9/0073 , A61K31/16 , A61K31/727 , A61K38/00 , A61K38/1709 , A61K38/1816 , A61K38/27 , A61K38/28 , A61K38/29 , A61K38/30 , A61K47/183
摘要： The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.
摘要翻译： 本发明提供了通过肺部途径向需要该药物的动物施用活性剂的方法。 该方法包括通过肺部途径施用包含（a）活性剂和（b）（i）酰化氨基酸，（ii）磺化氨基酸或（iii）（i）和（i） ii）。 施用本发明的组合物比单独施用活性剂提供了改善的肺输送和活性剂的更大的生物利用度。 结果，当与本发明的组合物相比时，可以施用较少量的活性剂以获得期望的结果。
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公开(公告)号：US06440929B1
公开(公告)日：2002-08-27
申请号：US09744777
申请日：2001-04-26
申请人： Sam J. Milstein , John E. Smart , Donald J. Sarubbi , Monica Leipold , Elizabeth Flanders , Doris O'Toole , Andrea Leone-Bay , David Gschneidner
发明人： Sam J. Milstein , John E. Smart , Donald J. Sarubbi , Monica Leipold , Elizabeth Flanders , Doris O'Toole , Andrea Leone-Bay , David Gschneidner
IPC分类号： A61K3800
CPC分类号： C07C235/64 , A61K9/0073 , A61K31/16 , A61K31/727 , A61K38/00 , A61K38/1709 , A61K38/1816 , A61K38/27 , A61K38/28 , A61K38/29 , A61K38/30 , A61K47/183
摘要： The present invention relates to pulmonary delivery of active agents. Acylated or sufonated amino acids are used as carriers to facilitate pulmonary delivery of active agents to a target.
摘要翻译： 本发明涉及活性剂的肺部递送。 使用酰化或辅助氨基酸作为载体以促进活性剂向目标物的肺部递送。
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公开(公告)号：US20050272638A1
公开(公告)日：2005-12-08
申请号：US11173075
申请日：2005-06-30
申请人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
发明人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
IPC分类号： A61K9/00 , A61K31/727 , A61K38/22 , A61K38/27 , A61K47/10 , A61K47/16 , A61K47/18 , A61K47/22 , A61P5/18 , C07C233/25 , C07C233/51 , C07C233/54 , C07C233/81 , C07C233/83 , C07C235/24 , C07C235/34 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D311/68 , C07D317/68 , A61K31/195
CPC分类号： C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号：US06991798B1
公开(公告)日：2006-01-31
申请号：US09762067
申请日：1999-08-06
申请人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
发明人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
IPC分类号： A61K38/00
CPC分类号： A61K45/06 , A61K9/0095 , A61K9/08 , A61K31/166 , A61K38/1816 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/22 , A61K2039/60 , A61K2300/00
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号：US07186414B2
公开(公告)日：2007-03-06
申请号：US11173075
申请日：2005-06-30
申请人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
发明人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
CPC分类号： C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译： 提供用于递送活性剂的化合物和组合物。 也提供给药和制备方法。
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公开(公告)号：US20070010422A1
公开(公告)日：2007-01-11
申请号：US11531602
申请日：2006-09-13
申请人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
发明人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
IPC分类号： A61K38/16 , A61K38/22 , A61K31/715 , A61K31/56 , C07C237/10
CPC分类号： C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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