公开(公告)号：US20100150872A1

公开(公告)日：2010-06-17

申请号：US12302690

申请日：2007-05-30

申请人： Andreas Bikfalvi ,  Carlo Sala ,  Lorenzo Bello

发明人： Andreas Bikfalvi ,  Carlo Sala ,  Lorenzo Bello

IPC分类号： A61K38/46 ,  C12N9/50 ,  C12N9/96 ,  C12N15/57 ,  C12N15/63 ,  C12N5/00 ,  A61K31/7052 ,  A61K35/12 ,  A61P35/00 ,  A61P19/02 ,  A61P3/10 ,  A61P17/06 ,  A61P17/00 ,  A61P29/00

CPC分类号： C12N9/6491

摘要： The present invention relates to anti-angiogenic polypeptides derived from the non catalytic C-terminal hemopexin-like domain of the metalloproteinase MMP-2. The invention also provides pharmaceutical compositions comprising said anti-angiogenic polypeptides and methods for using said polypeptide for treating angiogenic diseases, and in particular for treating cancer.

摘要翻译： 本发明涉及源自金属蛋白酶MMP-2的非催化性C-末端血凝素样结构域的抗血管生成多肽。 本发明还提供包含所述抗血管生成多肽的药物组合物和使用所述多肽治疗血管生成疾病，特别是用于治疗癌症的方法。

公开(公告)号：US06478520B1

公开(公告)日：2002-11-12

申请号：US09539547

申请日：2000-03-31

申请人： Carlo Sala

发明人： Carlo Sala

IPC分类号： A16B2500

CPC分类号： F16B25/0021 ,  F16B25/0047

摘要： Described herein is a self-threading screw, designed to be inserted in a hole of appropriate size made in a sheet of metal (or other metallic body), which has at the free end of its shank six projections (“formers” or “shapers”) of prismatic shape designed to thread by rolling the wall of the hole in which the screw itself is inserted.

摘要翻译： 这里描述的是一种自攻螺丝，其被设计成插入在金属片（或其他金属体）制成的适当尺寸的孔中，该金属片（或其他金属体）在其柄部的自由端处具有六个突起（“成形器”或“成形器 “），其设计成通过滚动其中插入螺钉本身的孔的壁而进行螺纹。

公开(公告)号：US06749056B2

公开(公告)日：2004-06-15

申请号：US10270396

申请日：2002-10-15

申请人： Carlo Sala

发明人： Carlo Sala

IPC分类号： B65G2500

CPC分类号： B23Q1/032 ,  B30B5/02

摘要： Method and device for resetting the position of pins in trays with pins for supporting objects to be clad inside presses, comprising a tray arranged on a substantially horizontal plane and in which there are multiple receptacles having a substantially vertical axis, each receptacle accommodating a pin provided with a head protruding from the upper face of the tray. The pins form with their heads a supporting surface for the lower face of the object to be placed in the press. Each pin has elastic means that keep the pin in a raised position and are flexible so as to allow the pin to pass from the raised position to a lowered position or vice versa. The method consists in making the tray slide along a resetting surface having, along its extension, a region raised with respect to a plane that is parallel to the plane of arrangement of the tray. The raised region is suitable to gradually make contact with the lower end of the pins in the lowered position, as they pass at the raised region, to produce their transfer to the raised position.

摘要翻译： 用于将托盘中的销的位置重新设置为用于支撑要包覆的压力机内的物体的方法和装置，包括布置在基本上水平的平面上的托盘，其中具有大致垂直轴线的多个容器，每个容器容纳一个销， 头部从托盘的上表面突出。 这些销与其头部形成用于待放置在压机中的物体的下表面的支撑表面。 每个销具有弹性装置，其将销保持在升高位置并且是柔性的，以便使销从升高位置传递到降低位置，反之亦然。 该方法包括使托盘沿着复位表面滑动，该复位表面具有沿其延伸部分相对于平行于托盘平面的平面升高的区域。 凸起区域适合于当它们在升高区域通过时逐渐与销的下端接触，从而将其转移到升高位置。

公开(公告)号：US5641258A

公开(公告)日：1997-06-24

申请号：US416149

申请日：1995-04-04

申请人： Carlo Sala

发明人： Carlo Sala

IPC分类号： B25B15/00 ,  B25B21/00 ,  F16B23/00

CPC分类号： F16B23/003 ,  F16B23/0069 ,  F16B23/0092

摘要： The screw, of the type provided with a coaxial recess adapted to mate with the tip of a screwing tool has in plan view a configuration in the overall form of a star with six chamfered points, with the lateral walls of the recess flared outwards and inclined to the screw axis by an angle of between 7 and 15 degrees. The sides of the chamfered points of the star consist of flat surfaces, pairs of which form on the lateral wall of the recess six corresponding ribs of isosceles triangle cross-section, the angle at the vertex of the isosceles triangle being substantially 90 degrees and the height of the triangle being substantially equal to one half the base length of said isosceles triangle. The screwing tool has a tip which mates with the lateral walls of the screw recess.

摘要翻译： 具有适于与螺丝刀的尖端配合的同轴凹槽的类型的螺钉在平面图中具有整体形式的具有六个倒角点的星形结构，其中凹口的侧壁向外张开并倾斜 以螺旋轴线旋转7至15度之间的角度。 星形的倒角点的两侧由平坦表面组成，其一对在凹槽的侧壁上形成六个等腰三角形横截面的肋，等腰三角形顶点的角度基本上为90度， 三角形的高度基本上等于所述等腰三角形的基本长度的一半。 螺丝刀具有与螺钉凹槽的侧壁配合的尖端。