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公开(公告)号：US20120189492A1
公开(公告)日：2012-07-26
申请号：US13380606
申请日：2010-06-24
申请人： Pedro J.J. Alvarez , Jaesang Lee , Lon J. Wilson , Yuri Mackeyev , Jaehong Kim
发明人： Pedro J.J. Alvarez , Jaesang Lee , Lon J. Wilson , Yuri Mackeyev , Jaehong Kim
IPC分类号： A61L2/10 , C07D265/30 , C07C233/16 , B01J19/08 , C07F7/08 , A61L2/08 , C07C55/02 , C07C229/04 , B82Y99/00 , B82Y30/00
摘要： In various embodiments, the present disclosure describes fullerene derivatives that are capable of photocatalytically generating reactive oxygen species in the presence of ultraviolet and/or visible light. In some embodiments, the fullerene derivatives are aminofullerenes containing a plurality of amine-terminated moieties covalently bonded to the fullerene cage. The fullerene derivatives may optionally be covalently bonded to a substrate surface for use in photocatalytic disinfection systems for removing various contaminants including, for example, bacteria, viruses, protozoa and chemical pollutants. Methods using the present fullerene and aminofullerene derivatives in various purification processes are also described herein.
摘要翻译： 在各种实施方案中，本公开描述了在紫外线和/或可见光存在下能够光催化产生活性氧的富勒烯衍生物。 在一些实施方案中，富勒烯衍生物是含有共价键合到富勒烯笼上的多个胺封端部分的氨基富勒烯。 富勒烯衍生物可以任选地共价结合到基底表面，用于光催化消毒系统中，用于除去诸如细菌，病毒，原生动物和化学污染物的各种污染物。 本文还描述了在各种纯化方法中使用本发明富勒烯和氨基富勒烯衍生物的方法。
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公开(公告)号：US08679442B2
公开(公告)日：2014-03-25
申请号：US13380606
申请日：2010-06-24
申请人： Pedro J. J. Alvarez , Jaesang Lee , Lon J. Wilson , Yuri Mackeyev , Jaehong Kim
发明人： Pedro J. J. Alvarez , Jaesang Lee , Lon J. Wilson , Yuri Mackeyev , Jaehong Kim
IPC分类号： B01J19/08
摘要： In various embodiments, the present disclosure describes fullerene derivatives that are capable of photocatalytically generating reactive oxygen species in the presence of ultraviolet and/or visible light. In some embodiments, the fullerene derivatives are aminofullerenes containing a plurality of amine-terminated moieties covalently bonded to the fullerene cage. The fullerene derivatives may optionally be covalently bonded to a substrate surface for use in photocatalytic disinfection systems for removing various contaminants including, for example, bacteria, viruses, protozoa and chemical pollutants. Methods using the present fullerene and aminofullerene derivatives in various purification processes are also described herein.
摘要翻译： 在各种实施方案中，本公开描述了在紫外线和/或可见光存在下能够光催化产生活性氧的富勒烯衍生物。 在一些实施方案中，富勒烯衍生物是含有共价键合到富勒烯笼上的多个胺封端部分的氨基富勒烯。 富勒烯衍生物可以任选地共价结合到基底表面，用于光催化消毒系统中，用于除去诸如细菌，病毒，原生动物和化学污染物的各种污染物。 本文还描述了在各种纯化方法中使用本发明富勒烯和氨基富勒烯衍生物的方法。
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3.发明授权公开(公告)号：US08128901B2
公开(公告)日：2012-03-06
申请号：US12299691
申请日：2007-05-07
申请人： Yuri Mackeyev , Lon J. Wilson
发明人： Yuri Mackeyev , Lon J. Wilson
IPC分类号： C01B37/02
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/17 , C01B2202/02 , C01B2202/04 , C01B2202/06 , Y10S977/752
摘要： A method of removing metal impurities from carbon nanotubes includes treating carbon nanotubes with distilled bromine in a substantially oxygen- and water-free atmosphere and then removing the distilled bromine from the carbon nanotubes. Purified carbon nanotubes having an iron content from about 2.5 to about 3.5 by weight that are substantially free of derivatization at the ends and defect sites are made available via this method.
摘要翻译： 从碳纳米管除去金属杂质的方法包括在基本上无氧和无水的气氛中用蒸馏的溴处理碳纳米管，然后从碳纳米管中除去蒸馏的溴。 通过这种方法可以获得铁含量约2.5至约3.5重量％的纯化碳纳米管，其基本上不含末端和缺陷位点的衍生化。
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公开(公告)号：US20120052008A1
公开(公告)日：2012-03-01
申请号：US13218213
申请日：2011-08-25
申请人： Yuri Mackeyev , Lon J. Wilson , Izabela Tworowska
发明人： Yuri Mackeyev , Lon J. Wilson , Izabela Tworowska
CPC分类号： A61K51/1251 , B82Y5/00
摘要： Nanostructures comprising radioisotopes and/or metals are provided. More particularly, in some embodiments, nanostructures comprising radioisotopes and/or metals, methods of their synthesis, and their use in cancer imaging and therapy are provided.
摘要翻译： 提供了包含放射性同位素和/或金属的纳米结构。 更具体地，在一些实施方案中，提供了包含放射性同位素和/或金属的纳米结构，其合成方法及其在癌症成像和治疗中的用途。
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5.发明申请FACILE PURIFICATION OF CARBON NANOTUBES WITH LIQUID BROMINE AT ROOM TEMPERATURE 有权碳氢化合物在室温下的液体纯化的纯化公开(公告)号：US20100021367A1
公开(公告)日：2010-01-28
申请号：US12299691
申请日：2007-05-07
申请人： Yuri Mackeyev , Lon J. Wilson
发明人： Yuri Mackeyev , Lon J. Wilson
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/17 , C01B2202/02 , C01B2202/04 , C01B2202/06 , Y10S977/752
摘要： A method of removing metal impurities from carbon nanotubes includes treating carbon nanotubes with distilled bromine in a substantially oxygen- and water-free atmosphere and then removing the distilled bromine from the carbon nanotubes. Purified carbon nanotubes having an iron content from about 2.5 to about 3.5 by weight that are substantially free of derivatization at the ends and defect sites are made available via this method.
摘要翻译： 从碳纳米管除去金属杂质的方法包括在基本上无氧和无水的气氛中用蒸馏的溴处理碳纳米管，然后从碳纳米管中除去蒸馏的溴。 通过这种方法可以获得铁含量约2.5至约3.5重量％的纯化碳纳米管，其基本上不含末端和缺陷位点的衍生化。
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公开(公告)号：US08986942B2
公开(公告)日：2015-03-24
申请号：US13473120
申请日：2012-05-16
CPC分类号： A61K51/00 , A61K49/0409 , A61K49/0447 , B82Y5/00
摘要： Compositions and methods related to carbon nanotubes are provided. More particularly, imaging agents comprising carbon nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent.
摘要翻译： 提供了与碳纳米管相关的组成和方法。 更具体地，提供了包含内部装有造影剂的碳纳米管和相关方法的成像剂。 方法的一个实例可以涉及一种用于成像的方法，其包括：提供包含负载有造影剂的碳纳米管的成像剂; 将成像剂引入细胞中; 并对细胞成像以检测成像剂的存在。
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公开(公告)号：US20130130295A1
公开(公告)日：2013-05-23
申请号：US13473120
申请日：2012-05-16
IPC分类号： A61K51/00
CPC分类号： A61K51/00 , A61K49/0409 , A61K49/0447 , B82Y5/00
摘要： Compositions and methods related to carbon nanotubes are provided. More particularly, imaging agents comprising carbon nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent.
摘要翻译： 提供了与碳纳米管相关的组成和方法。 更具体地，提供了包含内部装有造影剂的碳纳米管的成像剂和相关方法。 方法的一个实例可以涉及一种用于成像的方法，其包括：提供包含负载有造影剂的碳纳米管的成像剂; 将成像剂引入细胞中; 并对细胞成像以检测成像剂的存在。
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公开(公告)号：US20080193490A1
公开(公告)日：2008-08-14
申请号：US11841087
申请日：2007-08-20
CPC分类号： B82Y30/00 , A61K9/0092 , A61K47/6949 , A61K49/0004 , B82Y5/00
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is associated with the carbon nanotubes.
摘要翻译： 公开了向哺乳动物施用治疗剂的组合物和方法。 所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中 治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管相关联。
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公开(公告)号：US20120052004A1
公开(公告)日：2012-03-01
申请号：US13022286
申请日：2011-02-07
申请人： Lon J. Wilson , Jeyarama Subramanian Ananta Narayanan , Balaji Sitharaman , Keith Bennett Hartman
发明人： Lon J. Wilson , Jeyarama Subramanian Ananta Narayanan , Balaji Sitharaman , Keith Bennett Hartman
CPC分类号： A61K49/1884 , B82Y5/00
摘要： A contrast agent composition comprising at least one carbon nanotube and a metal catalyst. A method for obtaining a magnetic resonance image, the method comprising: administering to a subject a contrast agent composition, wherein a contrast agent composition comprises at least one carbon nanotube and a metal catalyst; and obtaining a magnetic resonance image of at least a portion of the subject in which the contrast agent is disposed.
摘要翻译： 包含至少一种碳纳米管和金属催化剂的造影剂组合物。 一种获得磁共振图像的方法，所述方法包括：向对象施用造影剂组合物，其中造影剂组合物包含至少一种碳纳米管和金属催化剂; 以及获得其中设置造影剂的对象的至少一部分的磁共振图像。
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公开(公告)号：US20080175892A1
公开(公告)日：2008-07-24
申请号：US11841524
申请日：2007-08-20
IPC分类号： A61K9/127 , A61K47/42 , A61K9/12 , A61P35/00 , A61K31/337
CPC分类号： A61K31/337 , A61K9/0078 , A61K9/127 , A61K47/6949 , B82Y5/00
摘要： Nanostructure-drug conjugates and associated methods of use are provided. In one embodiment, a nanostructure-drug conjugate comprising a Cn, a crosslinker, and a drug is provided, wherein Cn refers to a fullerene moiety or nanotube comprising n carbon atoms. A method of treating cancer is also provided, comprising administering a therapeutically effective amount of a nanostructure-drug conjugate comprising: a Cn, a crosslinker, and a drug, wherein Cn refers to a fullerene moiety comprising n carbon atoms to a mammal.
摘要翻译： 提供了纳米结构 - 药物共轭物和相关使用方法。 在一个实施方案中，提供了包含C n N，交联剂和药物的纳米结构药物缀合物，其中C n是指包含n碳的富勒烯部分或纳米管 原子 还提供了一种治疗癌症的方法，包括施用治疗有效量的纳米结构 - 药物缀合物，其包含：C n N，交联剂和药物，其中C n 指向哺乳动物包含n个碳原子的富勒烯部分。
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