摘要:
Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-&ggr; mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.
摘要:
17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formula wherein the phenyl group labeled A and the group —C(R4)(R6)Y are oriented cis to each other; W represents O or S; R1 represents —H or optionally substituted —(C1-C4)alkyl; n represents 0 or an integer of 1-3; and R2 represents any of a variety of substituents on ring A. R4 generally represents —H but may be a bond terminating at the ortho position of ring A. Y represents fluorine, —OR5, or —SR5, and R5 represents —H, optionally substituted —(C1-C4)alkyl, optionally substituted -phenyl, optionally substituted —(C1-C4)alkyl-phenyl, or optionally substituted —(C1-C4)acyl. R6 represents any of a variety of groups as defined in the specification and claims, including heteroaryl, arylalkyl, heteroarylalkyl, arylalkenyl, heteroarylalkenyl, alkynyl, arylalkynyl, heteroarylalkynyl, aryl, and indolyl. Pharmaceutically acceptable salts and N-oxides of these materials are also included. Also claimed are pharmaceutical compositions containing these materials and methods of using them.
摘要:
This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
摘要:
This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
摘要:
An apparatus for delivering RF-modulated electromagnetic energy into a solution for modifying its characteristics. Characteristic of the delivery apparatus is the use of a coil and a voltage probe in a fluid electrically isolated from the solution to deliver the electromagnetic field. Embodiments of the present invention preferably control the magnitude and duty cycle of the electromagnetic energy and further preferably distribute a plurality of delivery apparatus according to the energy distribution of a selected delivery apparatus.
摘要:
The present invention solves the problems of reliably initiating a low energy fusion reaction by loading deuterium into palladium metal via the process of electrolysis and by initiating the fusion reaction via the application of nuclear acoustic resonance. Affixed on each side of an electrolysis cell are piezoelectric transducers driven by corresponding frequency synthesizers. Surrounding the cell is a magnetic field produced by a magnetic field generator. The application of nuclear acoustic resonance, i.e. the combined application of an alternating magnetic field and of high frequency acoustic waves causes the deuterium atoms resident in the closely packed palladium metallic lattice to fuse into helium atoms with the consequent release of energy that is inherent to the fusion process.
摘要:
The food pan carrier has a pan carrier body and a pan carrier door. The pan carrier door is slidable relative to the pan carrier body from an open to a closed position. When the door is in the closed position, the food pan carrier will maintain food that has been heated to at least 185° at a minimum of 141° for an extended period of time. The pan carrier body has grooves in which the food pan door is received. The food pan door preferably has rails that are slidable in the grooves. The door slides in the grooves from a second end to a first end of the grooves. As the door slides from the open to the closed position, it moves toward a sealing surface that circumscribes an opening through which food pans are inserted and removed from the pan carrier body. In the fully closed position, the door sealingly engages the sealing surface that circumscribes the opening through which food pans are inserted and removed.
摘要:
An access panel located in a motor control center for inspecting and accessing various bus connections, for example, a particular phase vertical to horizontal bus connection or a horizontal bus bar splice connection. The surface of the panel includes one or more apertures positioned to align with one or more bus bar connections. Covers are pivotally mounted along the surface of the panel adjacent to the apertures in order to access and isolate the bus connections within the motor control center. The cover is mounted to the surface of the panel such that it can be moveable between open and closed positions.
摘要:
A door latch for latching a door of an electrical equipment enclosure includes a latch body and a latch rod rotatable between locked and unlocked conditions. The latch rod includes a stem with a first end rotatably coupled to the latch body, an extension rod with a first end coupled to a second end of the stem, and a hook coupled to a second end of the extension rod. The extension rod is dimensioned to contact a portion of the electrical equipment enclosure when the latch rod is in the locked condition. The hook is separated from the portion of the electrical equipment enclosure by a clearance distance “x” during a quiescent condition within the electrical enclosure. The hook contacts the portion of the electrical equipment enclosure during a pressurized condition within the electrical equipment enclosure. The clearance distance “x” is selected to provide a clearance distance “y” between the door and the enclosure to allow pressurized gas to escape the enclosure during the pressurized condition.