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公开(公告)号：US07803956B2
公开(公告)日：2010-09-28
申请号：US12471335
申请日：2009-05-22
申请人： Chengzhi Zhang , Jacques Dumas , Gaetan H. Ladouceur , Qian Zhao , Martin F. Hentemann , Sharad K. Verma , Qingming Zhu , Rico C. Lavoie , Jianmei Fan , Barton Phillips
发明人： Chengzhi Zhang , Jacques Dumas , Gaetan H. Ladouceur , Qian Zhao , Martin F. Hentemann , Sharad K. Verma , Qingming Zhu , Rico C. Lavoie , Jianmei Fan , Barton Phillips
IPC分类号： C07D307/87 , A01N43/12 , A01N43/08
CPC分类号： C07D307/83 , C07D307/80 , C07D307/81 , C07D307/82 , C07D405/04
摘要： The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
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公开(公告)号：US20090292014A1
公开(公告)日：2009-11-26
申请号：US12471335
申请日：2009-05-22
申请人： Chengzhi Zhang , Jacques Dumas , Gaetan H. Ladouceur , Qian Zhao , Martin F. Hentemann , Sharad K. Verma , Qingming Zhu , Rico C. Lavoie , Jianmei Fan , Barton Phillips
发明人： Chengzhi Zhang , Jacques Dumas , Gaetan H. Ladouceur , Qian Zhao , Martin F. Hentemann , Sharad K. Verma , Qingming Zhu , Rico C. Lavoie , Jianmei Fan , Barton Phillips
IPC分类号： A61K31/343
CPC分类号： C07D307/83 , C07D307/80 , C07D307/81 , C07D307/82 , C07D405/04
摘要： The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders
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3.发明授权公开(公告)号：US07420066B2
公开(公告)日：2008-09-02
申请号：US10566343
申请日：2004-08-06
申请人： Chengzhi Zhang , Jacques Dumas , Gaetan H. Ladouceur , Qian Zhao , Martin F. Hentemann , Sharad K. Verma , Qingming Zhu , Rico C. Lavoie , Jianmei Fan , Barton Phillips
发明人： Chengzhi Zhang , Jacques Dumas , Gaetan H. Ladouceur , Qian Zhao , Martin F. Hentemann , Sharad K. Verma , Qingming Zhu , Rico C. Lavoie , Jianmei Fan , Barton Phillips
IPC分类号： C07D307/87 , A61K31/34
CPC分类号： C07D307/83 , C07D307/80 , C07D307/81 , C07D307/82 , C07D405/04
摘要： The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
摘要翻译： 本发明涉及式（I）的新型杂环，其制备方法及其用于制备用于治疗或预防病症，特别是过度增殖性疾病的药物的用途。
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4.发明授权Benzofuran and dihydrobenzofuran derivatives useful as beta-3 adrenoreceptor agonists 失效可用作β-3肾上腺素受体激动剂的苯并呋喃和二氢苯并呋喃衍生物公开(公告)号：US06780859B2
公开(公告)日：2004-08-24
申请号：US10241250
申请日：2002-09-10
IPC分类号： A61K3165
CPC分类号： C07D405/12 , C07D307/81 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： This invention relates to novel benzofuran and dihydrobenzofuran compounds, pharmaceutical compositions containing such compounds, and methods of treating beta-3 adrenoreceptor-mediated conditions with such compositions.
摘要翻译： 本发明涉及新的苯并呋喃和二氢苯并呋喃化合物，含有这些化合物的药物组合物，以及用这些组合物治疗β-3肾上腺素受体介导的病症的方法。
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5.发明授权Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists 失效二取代氨基甲基 - 苯并二氢吡喃衍生物β-3肾上腺素受体激动剂公开(公告)号：US06699860B2
公开(公告)日：2004-03-02
申请号：US10008928
申请日：2001-12-07
申请人： Gaetan H. Ladouceur , William H. Bullock , Steven R. Magnuson , Stephen J. O'Connor , Roger A. Smith , Quanrong Shen , Qingjie Liu , Ning Su , Emil J. Velthuisen , Ann-Marie Campbell , Paul P. Ehrlich
发明人： Gaetan H. Ladouceur , William H. Bullock , Steven R. Magnuson , Stephen J. O'Connor , Roger A. Smith , Quanrong Shen , Qingjie Liu , Ning Su , Emil J. Velthuisen , Ann-Marie Campbell , Paul P. Ehrlich
IPC分类号： C07D40112
CPC分类号： C07D405/12 , C07D311/58 , C07D407/04 , C07D409/04 , C07D417/04
摘要： This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3受体介导的病症的新型二取代氨基甲基苯并二氢吡喃衍生物。
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6.发明授权2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US06919371B2
公开(公告)日：2005-07-19
申请号：US10666903
申请日：2003-09-17
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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7.发明授权Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists 失效酰胺衍生物和使用它们作为选择性神经肽Y受体拮抗剂的方法公开(公告)号：US06410792B1
公开(公告)日：2002-06-25
申请号：US09294961
申请日：1999-04-20
IPC分类号： C07C21100
CPC分类号： A61K31/00
摘要： Amide derivatives and methods of administering the compositions to mammals to treat disorders such as obesity that are mediated by NPY and especially those mediated by NPY via the Y5 receptor.
摘要翻译： 酰胺衍生物和将组合物施用于哺乳动物以治疗由NPY介导的疾病如肥胖的方法，特别是通过Y5受体由NPY介导的那些。
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公开(公告)号：US06218431B1
公开(公告)日：2001-04-17
申请号：US08904119
申请日：1997-07-31
申请人： William R. Schoen , Gaetan H. Ladouceur , James H. Cook, II , Timothy G. Lease , Donald J. Wolanin , Richard H. Kramss , Donald L. Hertzog , Martin H. Osterhout
发明人： William R. Schoen , Gaetan H. Ladouceur , James H. Cook, II , Timothy G. Lease , Donald J. Wolanin , Richard H. Kramss , Donald L. Hertzog , Martin H. Osterhout
IPC分类号： A61K31275
CPC分类号： C07D213/30 , C07D213/32 , C07D213/34 , C07D213/38 , C07D213/50 , C07D213/55 , C07D213/64 , C07D213/70 , C07D213/74 , C07D213/80 , C07D215/14 , C07D221/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D411/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D487/04 , C07F7/1804
摘要： Substituted biphenyls having glucagon receptor antagonistic activity. Claimed compounds have the formula wherein R1a and R1b independently represent (C1-C6) alkyl; R2 represents (C1-C10) alkyl or substituted (C1-C10) alkyl wherein the substituents are independently from 1 to 3 of —SR7; R7 represents phenyl, or substituted phenyl wherein the substituents are independently 1-5 of halogen, trifluoromethyl, (C1-C6) alkyl, (C1-C6) alkoxy, nitro, cyano, or hydroxyl; R3 represents substituted (C1-C6) alkyl wherein the substituents are 1-2 hydroxyl groups; G represents a substituent selected from the group consisting of halogen, (C1-C6) alkyl, and OR4 wherein R4 is H or (C1-C6) alkyl; and y is 0 or an integer of 1-3. Pharmaceutical compositions containing such compounds and methods of treatment of glucagon-mediated conditions by administering such compounds are also claimed.
摘要翻译： 具有胰高血糖素受体拮抗活性的取代的联苯。 权利要求的化合物具有R1a和R1b独立地表示（C1-C6）烷基; R2代表（C1-C10）烷基或取代的（C1-C10）烷基，其中取代基独立地为1至3的-SR7; R7代表苯基或取代苯基，其中取代基独立地为1-5个卤素，三氟甲基，（C1-C6）烷基，（C1-C6）烷氧基，硝基，氰基或羟基; R3表示取代基（C1-C6）烷基，其中取代基是1-2个羟基; G表示选自卤素，（C1-C6）烷基和OR4的取代基，其中R4是H或（C1-C6）烷基; y为0或1-3的整数。 还要求保护含有这些化合物的药物组合物和通过施用这些化合物治疗胰高血糖素介导的病症的方法。
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9.发明申请公开(公告)号：US20090023783A1
公开(公告)日：2009-01-22
申请号：US12201547
申请日：2008-08-29
申请人： Chengzhi Zhang , Jacques Dumas , Gaetan H. Ladouceur , Qian Zhao , Martin Hentemann , Sharad K. Verma , Qingming Zhu , Rico C. Lavoie , Jianmei Fan , Barton Phillips
发明人： Chengzhi Zhang , Jacques Dumas , Gaetan H. Ladouceur , Qian Zhao , Martin Hentemann , Sharad K. Verma , Qingming Zhu , Rico C. Lavoie , Jianmei Fan , Barton Phillips
IPC分类号： A61K31/443 , C07D307/85 , C07D407/10 , A61P35/00 , A61K31/343
CPC分类号： C07D307/83 , C07D307/80 , C07D307/81 , C07D307/82 , C07D405/04
摘要： The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders
摘要翻译： 本发明涉及新的苯并呋喃衍生物，其制备方法及其用于制备用于治疗或预防病症，特别是过度增殖性疾病的药物的用途
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公开(公告)号：US06903218B2
公开(公告)日：2005-06-07
申请号：US10667286
申请日：2003-09-19
申请人： Gaetan H. Ladouceur , Richard D. Connell , Jeremy Baryza , Ann-Marie Campbell , Timothy G. Lease , James H. Cook
发明人： Gaetan H. Ladouceur , Richard D. Connell , Jeremy Baryza , Ann-Marie Campbell , Timothy G. Lease , James H. Cook
IPC分类号： C07D213/30 , C07D213/50 , C07D213/61 , C07D233/70 , C07D257/04 , C07D311/24 , C07D311/58 , C07D311/66 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04
CPC分类号： C07D213/30 , C07D213/50 , C07D213/61 , C07D233/70 , C07D257/04 , C07D311/24 , C07D311/58 , C07D311/66 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04
摘要： This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3受体介导的病症的新型磺酰胺取代的苯并二氢吡喃衍生物。
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