-
公开(公告)号：US20110104788A1
公开(公告)日：2011-05-05
申请号：US12866557
申请日：2009-02-09
申请人： Andrew Baker , Simon Waddington , John McVey
发明人： Andrew Baker , Simon Waddington , John McVey
CPC分类号： A61K38/162 , A61K35/58 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10345 , C12N2810/6018 , C12N2810/857 , G01N33/56983 , G01N2333/075 , G01N2333/745 , G01N2500/02
摘要： The invention provides materials and methods for modulating adenoviral tropism for hepatocytes and other cell types such as splenocytes. It relates to the findings that hypervariable regions (HVRs) of the viral hexon protein interact with the Gla domain of the blood clotting factor FX as part of the infective process in vivo. The invention provides means to disrupt the interaction between hexon and FX, thus reducing infection of hepatocytes and splenocytes, as well as use of targeting agents comprising the Gla domain or a fragment thereof to direct adenoviral vectors to desired target cell or tissue types.
摘要翻译： 本发明提供用于调节肝细胞和其他细胞类型如脾细胞的腺病毒向性的材料和方法。 它涉及病毒六邻体蛋白的高变区（HVR）与凝血因子FX的Gla结构域作为体内感染过程的一部分相互作用的发现。 本发明提供了破坏六邻体和FX之间的相互作用的手段，从而减少肝细胞和脾细胞的感染，以及使用包含Gla结构域或其片段的靶向剂将腺病毒载体引导至期望的靶细胞或组织类型。
-
公开(公告)号：US09393323B2
公开(公告)日：2016-07-19
申请号：US13382953
申请日：2010-07-08
申请人： Amit Nathwani , Natalie Ward , Adrian Thrasher , Edward Tuddenham , John McVey , John Gray , Andrew Davidoff
发明人： Amit Nathwani , Natalie Ward , Adrian Thrasher , Edward Tuddenham , John McVey , John Gray , Andrew Davidoff
IPC分类号： C07H21/04 , A61K31/70 , A61K48/00 , C07K14/755 , C12N15/86 , A61K38/37 , C12N7/00 , A01K67/00 , A61K38/00
CPC分类号： A61K48/0058 , A61K38/00 , A61K38/37 , C07K14/755 , C12N7/00 , C12N15/86 , C12N2710/10041 , C12N2710/14143 , C12N2750/14143 , C12N2800/22 , C12N2830/008
摘要： An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment.
摘要翻译： 人类血液凝固因子8（VIII）和启动子的优化编码序列可用于载体，例如rAAV，用于引入因子VIII和/或其它凝血因子和转基因。 这些因子和转基因的实例是α-1-抗胰蛋白酶，以及参与凝血级联，肝癌生物学，溶酶体储存，尿素循环障碍和脂质储存疾病的那些因子和转基因。 由载体和序列转化的细胞产生的细胞，载体，蛋白质和糖蛋白可用于治疗。
-
公开(公告)号：US5300044A
公开(公告)日：1994-04-05
申请号：US45291
申请日：1993-04-12
申请人： Donald J. Classey , Theresa Grajo , Kenneth Lynn , John McVey , Eric Myren , Gabriel Vehovsky
发明人： Donald J. Classey , Theresa Grajo , Kenneth Lynn , John McVey , Eric Myren , Gabriel Vehovsky
CPC分类号： A61M39/281 , A61M39/287 , A61M2205/60 , A61M5/142 , A61M5/14228 , Y10S128/12
摘要： The present invention provides an apparatus for use in a peristaltic pump 20 which prevents an inadvertent free flow condition prior to loading or after removal of an I.V. tube 26 in the peristaltic pump 20 and which also prevents the inadvertent occlusion of a loaded I.V. tube 26 in the peristaltic pump 20. A standard I.V. tube 26 has a slide clamp 109 provided thereon. The apparatus includes an I.V. tube groove 29 into which the I.V. tube 26 is positioned, a slide clamp receiving area 62 into which the slide clamp 109 is inserted, and a biased sliding member 81 which the inserted slide clamp 109 engages such that the I.V. tube 26 cannot be loaded into the apparatus without the slide clamp 109 occluding the I.V. tube 26. The present invention also contemplates a slide clamp 109, compatible with the apparatus having a surface pad 125 for facilitating automated identification of the slide clamp 109, in cooperation with a nonobstructive sensor 85 in the safety apparatus. The present invention further contemplates a slide clamp 109'. having an I.V. tube receiving aperture 110'with an inner diameter profile which minimizes friction between I.V. tube contacting surfaces 126 of the aperture 110'as an I.V. tube 26 is slid transverse to its length within the aperture 110' and which has a surface pad 125 for facilitating automated identification of the slide clamp.
摘要翻译： 本发明提供一种在蠕动泵20中使用的装置，其防止在装载之前或之后除去I.V.之前的无意的自由流动状态。 蠕动泵20中的管26，并且还防止加载的IV的意外闭塞。 蠕动泵20中的管26。 管26具有设置在其上的滑动夹具109。 该装置包括I.V. 管槽29，其中I.V. 管26定位，滑动夹具109插入其中的滑动夹具接收区域62和插入的滑动夹具109接合的偏置滑动构件81，使得I.V。 管26不能装载到装置中，而不夹紧I.V的滑动夹具109。 本发明还考虑与安全装置中的无阻尼传感器85协作的与具有表面垫125的装置兼容的滑动夹具109，以便于自动识别滑动夹具109。 本发明进一步考虑了滑动夹具109'。 有一个 管接收孔110'具有内径分布，其使得I.V. 孔110'的管接触表面126为I.V. 管26在孔110'内横向于其长度滑动，并且具有表面垫125，以便于自动识别滑动夹具。
-
公开(公告)号：US20130024960A1
公开(公告)日：2013-01-24
申请号：US13382953
申请日：2010-07-08
申请人： Amit Nathwani , Natalie Ward , Adrian Thrasher , Edward Tuddenham , John McVey , John Gray , Andrew Davidoff
发明人： Amit Nathwani , Natalie Ward , Adrian Thrasher , Edward Tuddenham , John McVey , John Gray , Andrew Davidoff
IPC分类号： C12N5/10 , A01K67/027 , C12N15/864 , C12N15/113 , A61K31/7088 , A61P7/04 , C12N15/85 , C12N15/12
CPC分类号： A61K48/0058 , A61K38/00 , A61K38/37 , C07K14/755 , C12N7/00 , C12N15/86 , C12N2710/10041 , C12N2710/14143 , C12N2750/14143 , C12N2800/22 , C12N2830/008
摘要： An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment.
摘要翻译： 人类血液凝固因子8（VIII）和启动子的优化编码序列可用于载体，例如rAAV，用于引入因子VIII和/或其它凝血因子和转基因。 这些因子和转基因的实例是α-1-抗胰蛋白酶，以及参与凝血级联，肝癌生物学，溶酶体储存，尿素循环障碍和脂质储存疾病的那些因子和转基因。 由载体和序列转化的细胞产生的细胞，载体，蛋白质和糖蛋白可用于治疗。
-
公开(公告)号：US5290239A
公开(公告)日：1994-03-01
申请号：US884498
申请日：1992-05-15
申请人： Donald J. Classey , Theresa Grajo , Kenneth Lynn , John McVey , Eric Myren , Gabriel Vehovsky
发明人： Donald J. Classey , Theresa Grajo , Kenneth Lynn , John McVey , Eric Myren , Gabriel Vehovsky
CPC分类号： A61M39/281 , A61M39/287 , A61M2205/60 , A61M5/142 , A61M5/14228 , Y10S128/12
摘要： The present invention provides an apparatus for use in a peristaltic pump 20 which prevents an inadvertent free flow condition prior to loading or after removal of an I.V. tube 26 in the peristaltic pump 20 and which also prevents the inadvertent occlusion of a loaded I.V. tube 26 in the peristaltic pump 20. A standard I.V. tube 26 has a slide clamp 109 provided thereon. The apparatus includes an I.V. tube groove 29 into which the I.V. tube 26 is positioned, a slide clamp receiving area 62 into which the slide clamp 109 is inserted, and a biased sliding member 81 which the inserted slide clamp 109 engages such that the I.V. tube 26 cannot be loaded into the apparatus without the slide clamp 109 occluding the I.V. tube 26. The present invention also contemplates a slide clamp 109' compatible with the apparatus having a surface pad 125 for facilitating automated identification of the slide clamp 109' in cooperation with a non-obstructive sensor 85 in the safety apparatus. The present invention further contemplates a slide clamp 109' having an I.V. tube receiving aperture 110' with an inner diameter profile which minimizes friction between I.V. tube contacting surfaces 126 of the aperture 110' as an I.V. tube 26 is slid transverse to its length within the aperture 110' and which has a surface pad 125 for facilitating automated identification of the slide clamp.
摘要翻译： 本发明提供一种在蠕动泵20中使用的装置，其防止在装载之前或之后除去I.V.之前的无意的自由流动状态。 蠕动泵20中的管26，并且还防止加载的IV的意外闭塞。 蠕动泵20中的管26。 管26具有设置在其上的滑动夹具109。 该装置包括I.V. 管槽29，其中I.V. 管26定位，滑动夹具109插入其中的滑动夹具接收区域62和插入的滑动夹具109接合的偏置滑动构件81，使得I.V。 管26不能装载到装置中，而不夹紧I.V的滑动夹具109。 本发明还考虑了与装置兼容的滑动夹具109'，其具有表面垫125，用于与安全装置中的非阻塞性传感器85协作，便于自动识别滑动夹具109'。 本发明进一步考虑了具有I.V.的滑动夹具109'。 管接收孔110'具有内径分布，其使得I.V. 孔110'的管接触表面126为I.V. 管26在孔110'内横向于其长度滑动，并且具有表面垫125，以便于自动识别滑动夹具。
-
-
公开(公告)号：US20050116652A1
公开(公告)日：2005-06-02
申请号：US10726398
申请日：2003-12-02
申请人： John McVey , Andrew Perrucci , Edward Britt
发明人： John McVey , Andrew Perrucci , Edward Britt
CPC分类号： F03H1/0075
摘要： A Hall effect thruster for propelling spacecraft and satellites includes at least two acceleration channels, each of the channels has a closed end and an open end, and a plurality of flux guides adjacent each of the channels. The plurality of flux guides includes an innermost flux guide, an outermost flux guide, and at least one intermediate flux guide. Each intermediate flux guide helps provide a magnetic field to each of two adjacent acceleration channels.
摘要翻译： 用于推进航天器和卫星的霍尔效应推进器包括至少两个加速通道，每个通道具有封闭端和开口端，以及与每个通道相邻的多个通量引导件。 多个磁通引导件包括最内部的磁通引导件，最外面的磁通引导件和至少一个中间磁通引导件。 每个中间磁通引导件有助于为两个相邻加速度通道中的每一个提供磁场。
-
8.发明授权Method of producing a flemish eye on the end of a rope and a flemish eye device 失效在绳索末端产生一种ish眼的方法和一种ish眼装置
公开(公告)号：US4395798A
公开(公告)日：1983-08-02
申请号：US261975
申请日：1981-05-08
申请人： John McVey
发明人： John McVey
CPC分类号： D07B1/185 , F16G11/00 , Y10T24/3909
摘要： In forming flemish eyes at the ends of wire ropes to produce e.g. slings, serious difficulties arise when forming the anchorage for the spliced loops if the rope is of large diameter. The terminal end of the rope material has its component strands naturally laid on the rope, and it has been proposed to enclose the naturally laid strands in a cylindrical sleeve adjacent to the loop and introduce a hardenable anchoring material such as a resin into the sleeve to complete the anchorage.It is now found that improved loading distribution on a wire rope can be obtained through providing an anchorage for the loop in the form of a sleeve comprising a socket, and flaring-out into the socket the component wires of portions of the strands remote from the loop, the strand portions adjacent to the loop remaining naturally laid on the rope.
摘要翻译： 在丝绳末端形成fle眼的眼睛， 如果绳索的直径较大，则在拼接环形成锚固时会产生严重的困难。 钢丝绳材料的末端部分自然地铺设在绳索上，并且已经提出将自然铺设的绳索包围在与该环相邻的圆筒形套筒中，并将诸如树脂的可硬化锚定材料引入套筒中 完成锚地。 现在发现，通过为包括插座的套筒形式的环路提供锚固件，并且将插座中的部分线材的部件线向外扩展到插座中，可以获得改进的钢丝绳上的负载分布， 回路，与环路相邻的股线部分自然地放置在绳索上。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.02 秒)