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    Inhaled vaccines
    1.
    发明授权
    Inhaled vaccines 有权
    吸入疫苗

    公开(公告)号：US06651655B1

    公开(公告)日：2003-11-25

    申请号：US09562798

    申请日：2000-05-02

    申请人： Cynthia Licalsi ,  Gary Ward ,  Bernard Greenspan ,  Clyde Witham

    发明人： Cynthia Licalsi ,  Gary Ward ,  Bernard Greenspan ,  Clyde Witham

    IPC分类号： A61M1500

    CPC分类号： A61M15/0028 ,  A61M15/0043 ,  A61M2202/066 ,  A61M2202/30

    摘要： In a method for creating an immune response, a vaccine is prepared in the form of a dry powder. The powder particles have an aerodynamic particle size range from 1-100 microns. A dose of powder is loaded into a dry powder inhaler. The dose is inhaled with an inspiratory flow rate of less than 60 liters per minute. A mucosal immune response is created via particles of the vaccine material depositing on the upper respiratory tract. A systemic immune response is created via particles of the vaccine material depositing into the deep lung. The vaccine material is size reduced by e.g., jet milling, into the desired range, yet vaccine potency is retained.

    摘要翻译： 在产生免疫应答的方法中，以干燥粉末的形式制备疫苗。 粉末颗粒的空气动力学粒度范围为1-100微米。 将一剂粉末装入干粉吸入器。 吸入剂量的吸气流速小于60升/分钟。 通过沉积在上呼吸道上的疫苗材料的颗粒产生粘膜免疫应答。 通过沉积到深肺中的疫苗材料的颗粒产生全身免疫应答。 通过例如喷射研磨将疫苗材料的尺寸减小到所需的范围，但保留了疫苗效力。

    Dry powder inhaler
    2.
    发明授权
    Dry powder inhaler 有权
    干粉吸入器

    公开(公告)号：US06427688B1

    公开(公告)日：2002-08-06

    申请号：US09495494

    申请日：2000-02-01

    申请人： Michael Ligotke ,  Andrew W. Gieschen ,  Robert F. Eisele ,  Thomas R. Jackson ,  Jeffrey Chen ,  Bernard Greenspan ,  Clyde Witham ,  Gary Ward

    发明人： Michael Ligotke ,  Andrew W. Gieschen ,  Robert F. Eisele ,  Thomas R. Jackson ,  Jeffrey Chen ,  Bernard Greenspan ,  Clyde Witham ,  Gary Ward

    IPC分类号： A61M1500

    CPC分类号： A61M15/0086 ,  A61M15/0008 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/02 ,  A61M2202/064 ,  A61M2205/43 ,  A61M2206/16 ,  A61M2206/18

    摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.

    摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的空气流动和粉末分散，而不会增加患者的任何增加的努力。

    Method and apparatus for separation of oil from refrigerants
    3.
    发明授权
    Method and apparatus for separation of oil from refrigerants 失效
    从制冷剂中分离油的方法和装置

    公开(公告)号：US5092911A

    公开(公告)日：1992-03-03

    申请号：US585486

    申请日：1990-09-20

    申请人： J. Andy Williams ,  Clyde Witham

    发明人： J. Andy Williams ,  Clyde Witham

    IPC分类号： B01D15/00 ,  F25B43/00

    CPC分类号： B01D15/00 ,  F25B43/003 ,  Y10S95/902

    摘要： A method and apparatus for removing oil and water contaminants from chloro-fluoro carbon refrigerants. This system is a single pass filtration system specifically designed for sealed systems with no atmospheric bleed off of chloro-fluoro carbons. This system incorporates a novel oil absorbent and is compact enough for small commercial applications, such as service stations or portable service of environmental control units. This system also incorporates a new cartridge type filter containing both water and oil and particulate absorbtion and removal means.

    摘要翻译： 一种用于从氯 - 氟碳制冷剂中除去油和水污染物的方法和装置。 该系统是专门设计用于没有大气渗出氯 - 氟碳的密封系统的单程过滤系统。 该系统采用新型吸油剂，足够小巧的小型商业应用，如服务站或环境控制单元的便携式服务。 该系统还包含一个新的含有水和油的滤芯式过滤器，以及颗粒吸收和去除装置。

    Methods of dry powder inhalation
    5.
    发明授权
    Methods of dry powder inhalation 失效
    干粉吸入方法

    公开(公告)号：US06116237A

    公开(公告)日：2000-09-12

    申请号：US847287

    申请日：1997-04-24

    申请人： Robert Schultz ,  Clyde Witham ,  Malcolm Hill

    发明人： Robert Schultz ,  Clyde Witham ,  Malcolm Hill

    IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/00 ,  A61K38/00 ,  A61K38/22 ,  A61M15/00 ,  A61P11/00 ,  A61P11/06

    CPC分类号： A61K9/0075 ,  A61K9/0073 ,  A61M15/0045 ,  A61M15/0048 ,  A61M2202/064

    摘要： A method for inhalation of a dry powder drug includes the steps of providing a dry powder drug composition having a drug particle size of from about 1-7 microns and a mass median aerodynamic diameter of the delivered aerosol of from about 3.5 to 5.5 microns. This composition is loaded into an inhaler which is generally flow rate independent, and with the inhaler having an inspiration flow resistance of about 0.12 to 0.21 (cmH.sub.2 O).sup.1/2 over the range of about 15-60 L/min. The patient inhales the drug composition from the inhaler with an inspiration flow rate of about 15-60 L/min, resulting in a delivery efficiency measured by respirable fraction greater than 20%.

    摘要翻译： 吸入干粉药物的方法包括提供具有约1-7微米的药物粒度和约3.5至5.5微米的递送气溶胶的质量中值空气动力学直径的干燥粉末药物组合物的步骤。 该组合物装载到一般流速独立的吸入器中，并且吸入器具有在约15-60L / L范围内约0.12至0.21（cmH 2 O）+ E，fra 1/2 + EE的吸气流阻， 分钟 患者吸入吸入器中的药物组合物，吸气流速为约15-60升/分，导致通过可呼吸分数大于20％测定的输送效率。