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公开(公告)号：US20060100238A1
公开(公告)日：2006-05-11
申请号：US10532074
申请日：2003-11-02
申请人： Graham Kelly , Andrew Heaton , John Bremner
发明人： Graham Kelly , Andrew Heaton , John Bremner
IPC分类号： A61K31/4704 , A61K31/4706 , A61K31/382 , A61K31/353
CPC分类号： A61K31/352 , C07D311/68
摘要： Aminated isoflavonoid synthesized by aminating the 4-keto group of isoflavanone and isoflavanone ring systems, pharmaceutical compositions containing same and uses thereof as therapeutic agents.
摘要翻译： 通过胺化异黄酮和异黄烷酮环系的4-酮基合成的氨基异黄酮，含有其的药物组合物和其用作治疗剂。
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2.发明申请Compositions and therapeutic methods involving isoflavones and analogues thereof 审中-公开涉及异黄酮及其类似物的组合物和治疗方法公开(公告)号：US20060106220A1
公开(公告)日：2006-05-18
申请号：US11300976
申请日：2005-12-14
申请人： Andrew Heaton , Naresh Kumar , Graham Kelly , Alan Husband
发明人： Andrew Heaton , Naresh Kumar , Graham Kelly , Alan Husband
IPC分类号： A61K31/4745 , C07D471/04 , C07D405/02 , C07D409/02 , C07D401/02 , A61K31/4709
CPC分类号： C07D311/26 , A23L33/10 , A23L33/11 , A23V2002/00 , C07D311/36 , C07D311/38 , C07D311/58 , C07D471/06 , A23V2250/2116 , A23V2200/30
摘要： Isoflavone compounds and analogues thereof, compositions containing same and therapeutic methods of treatment involving same are described.
摘要翻译： 描述异黄酮化合物及其类似物，含有其的组合物和涉及其的治疗方法。
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3.发明申请Compositions and therapeutic methods involving isoflavones and analogues thereof 审中-公开涉及异黄酮及其类似物的组合物和治疗方法公开(公告)号：US20080014249A1
公开(公告)日：2008-01-17
申请号：US11901724
申请日：2007-09-17
申请人： Andrew Heaton , Naresh Kumar , Graham Kelly , Alan Husband
发明人： Andrew Heaton , Naresh Kumar , Graham Kelly , Alan Husband
IPC分类号： A61K47/00 , A61K31/35 , A61P29/00 , A61K31/355
CPC分类号： C07D311/26 , A23L33/10 , A23L33/11 , A23V2002/00 , C07D311/36 , C07D311/38 , C07D311/58 , C07D471/06 , A23V2250/2116 , A23V2200/30
摘要： Isoflavone compounds are described and recommended as therapeutic agents. Exemplified and preferred compounds are (a). Indications show compounds have good competitive binding to estrogen receptors. This is exemplified.
摘要翻译： 描述和推荐异黄酮化合物作为治疗剂。 示例性和优选的化合物是（a）。 适应症显示化合物与雌激素受体具有良好的竞争性结合。 这是例证。
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4.发明申请Isoflavonoid Prodrugs, Compositons Thereof and Therapeutic Methods Involving Same 审中-公开异黄酮类药物及其组合物及其治疗方法公开(公告)号：US20070244075A1
公开(公告)日：2007-10-18
申请号：US10579789
申请日：2004-11-18
申请人： Andrew Heaton , Graham Kelly
发明人： Andrew Heaton , Graham Kelly
IPC分类号： A61K31/662 , A61P15/00 , C07F9/09
CPC分类号： C07F9/65522 , A23L2/52 , A23L33/10 , A23V2002/00 , A23V2200/308 , A23V2200/322 , A23V2200/318 , A23V2200/30 , A23V2250/2116
摘要： Phosphate esters of isoflavonoid compounds are prepared for use as prodrugs, medicaments and in formulations, drinks and foodstuffs.
摘要翻译： 制备异黄酮化合物的磷酸酯用作前药，药物和制剂，饮料和食品。
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公开(公告)号：US20050049424A1
公开(公告)日：2005-03-03
申请号：US10493390
申请日：2002-10-25
申请人： Graham Kelly , Andrew Heaton
发明人： Graham Kelly , Andrew Heaton
IPC分类号： A61K31/12 , A61K31/352 , A61K31/353 , A61P1/00 , A61P1/16 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/08 , A61P15/00 , A61P17/00 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07C45/46 , C07C49/83 , C07C49/835 , C07D311/36 , C07D471/06 , C07D307/77 , C07D323/02
CPC分类号： C07D311/36 , A61K31/12 , A61K31/352 , A61K31/353 , C07C45/46 , C07C49/83 , C07C49/835 , C07D471/06
摘要： Isoflavone compounds of the formula (I) or (II) Where R can be R7? or OR7? or O and the formula (III) is either a single or double bond extends to Y then Y is an optionally substituted benzyl. W, R1?, Zo? R2? and R7? are as defined in the specification. The compounds are useful for the treatment of certain diseases and disorders, including cancer and inflammation.
摘要翻译： 式（I）或（II）的异黄酮化合物其中R可以是R
7？ 或OR 7？ 或O，式（III）是单键或双键延伸至Y，则Y为任选取代的苄基。 W，R 1 ?, Z o？ R 2？ 和R 7？ 如说明书中所定义。 该化合物可用于治疗某些疾病和病症，包括癌症和炎症。 -
公开(公告)号：US20060074126A1
公开(公告)日：2006-04-06
申请号：US11230505
申请日：2005-09-21
申请人： Andrew Heaton , Alan Husband
发明人： Andrew Heaton , Alan Husband
IPC分类号： C07D311/04 , A61K31/353
CPC分类号： A61K31/353 , A23L33/105 , A61K31/282 , A61K31/337 , A61K31/37 , A61K31/4745 , A61K31/655 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K41/0038 , A61N5/10 , A61N2005/1098 , C07D311/38 , C07D311/58 , C07D311/62
摘要： Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.
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公开(公告)号：US08461361B2
公开(公告)日：2013-06-11
申请号：US13415697
申请日：2012-03-08
申请人： Andrew Heaton , Alan Husband
发明人： Andrew Heaton , Alan Husband
IPC分类号： C07D311/00 , C07D307/77
CPC分类号： A61K31/353 , A23L33/105 , A61K31/282 , A61K31/337 , A61K31/37 , A61K31/4745 , A61K31/655 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K41/0038 , A61N5/10 , A61N2005/1098 , C07D311/38 , C07D311/58 , C07D311/62
摘要： Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.
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公开(公告)号：US08367659B2
公开(公告)日：2013-02-05
申请号：US12528208
申请日：2008-02-29
申请人： Andrew Heaton , Naresh Kumar , Catherine Walker
发明人： Andrew Heaton , Naresh Kumar , Catherine Walker
IPC分类号： A61F2/82 , A61K31/5365 , A61P9/00 , A61P31/00 , A61P39/06 , C07D498/04
CPC分类号： C07D498/04
摘要： The invention provides oxazinyl isoflavonoid compounds and compositions containing same, methods for their preparation and their use as therapeutic agents particularly as cardioprotective, anti-inflammatory, anti-oxidant and chemotherapeutic agents.
摘要翻译： 本发明提供了恶嗪基异黄酮化合物和含有其的组合物，其制备方法及其作为治疗剂的用途，特别是作为心脏保护剂，抗炎剂，抗氧化剂和化学治疗剂。
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公开(公告)号：US08080675B2
公开(公告)日：2011-12-20
申请号：US11230505
申请日：2005-09-21
申请人： Andrew Heaton , Alan Husband
发明人： Andrew Heaton , Alan Husband
IPC分类号： C07D311/00 , A61K31/35
CPC分类号： A61K31/353 , A23L33/105 , A61K31/282 , A61K31/337 , A61K31/37 , A61K31/4745 , A61K31/655 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K41/0038 , A61N5/10 , A61N2005/1098 , C07D311/38 , C07D311/58 , C07D311/62
摘要： Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.
摘要翻译： 描述了新型色氨酸衍生物和中间体化合物，含有它们的组合物，其制备方法及其作为治疗剂的治疗剂，特别是作为抗癌剂和化疗选择剂。
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公开(公告)号：US07906660B2
公开(公告)日：2011-03-15
申请号：US11442369
申请日：2006-05-25
申请人： Andrew Heaton , Naresh Kumar
发明人： Andrew Heaton , Naresh Kumar
IPC分类号： C07D311/60
CPC分类号： C07D311/56 , C07D311/36 , C07D311/38
摘要： Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.
摘要翻译： 描述了异黄酮氢化方法，其提供了可使用量的异黄烷-4-醇，异氟烷-3-烯和异构体。 异黄酮衍生物可以以高纯度和接近定量的产率获得，同时使用药学上可接受的试剂和溶剂。
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