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1.发明授权公开(公告)号：US08574189B2
公开(公告)日：2013-11-05
申请号：US13416236
申请日：2012-03-09
申请人： Andrew Poutiatine , Bruce Edwards , Charles Rampersaud , Pamela Palmer , Bradley Blackwood , Benjamin K. Yaffe
发明人： Andrew Poutiatine , Bruce Edwards , Charles Rampersaud , Pamela Palmer , Bradley Blackwood , Benjamin K. Yaffe
CPC分类号： G06F19/3462 , A61J7/0053 , A61J7/0418 , A61J7/0436 , A61J7/0445 , A61J7/0463 , A61J2200/30 , A61J2205/50 , A61J2205/60 , G06F19/00 , G06K19/07762 , G06K19/07783 , H04B5/0062
摘要： Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
摘要翻译： 提供了用于口腔粘膜给小剂量药物剂型口服粘膜的分配装置和系统。 分配装置可以是单剂量施用器（SDA），或者包括用于患者识别的装置的机电装置，例如腕部佩戴的RFID标签和环形双向天线以及锁定特征。
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公开(公告)号：US08548623B2
公开(公告)日：2013-10-01
申请号：US12724634
申请日：2010-03-16
申请人： Andrew Poutiatine , Bruce Edwards , Charles Rampersaud , Pamela Palmer , Bradley Blackwood , Benjamin K. Yaffe
发明人： Andrew Poutiatine , Bruce Edwards , Charles Rampersaud , Pamela Palmer , Bradley Blackwood , Benjamin K. Yaffe
IPC分类号： G06F17/00
CPC分类号： G06F19/3462 , A61J7/0053 , A61J7/0418 , A61J7/0436 , A61J7/0445 , A61J7/0463 , A61J2200/30 , A61J2205/50 , A61J2205/60 , G06F19/00 , G06K19/07762 , G06K19/07783 , H04B5/0062
摘要： Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
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3.发明申请Storage and Dispensing Devices for Administration of Oral Transmucosal Dosage Forms 有权用于口服粘膜粘膜剂量形式的储存和分配装置公开(公告)号：US20100253476A1
公开(公告)日：2010-10-07
申请号：US12724634
申请日：2010-03-16
IPC分类号： H04Q5/22
CPC分类号： G06F19/3462 , A61J7/0053 , A61J7/0418 , A61J7/0436 , A61J7/0445 , A61J7/0463 , A61J2200/30 , A61J2205/50 , A61J2205/60 , G06F19/00 , G06K19/07762 , G06K19/07783 , H04B5/0062
摘要： Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
摘要翻译： 提供了用于口腔粘膜给小剂量药物剂型口服粘膜的分配装置和系统。 分配装置可以是单剂量施用器（SDA），或者包括用于患者识别的装置的机电装置，例如腕部佩戴的RFID标签和环形双向天线以及锁定特征。
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4.发明申请STORAGE AND DISPENSING DEVICES FOR ADMINISTRATION OF ORAL TRANSMUCOSAL DOSAGE FORMS 有权用于管理口服剂量形式的储存和分配装置公开(公告)号：US20120232473A1
公开(公告)日：2012-09-13
申请号：US13416236
申请日：2012-03-09
CPC分类号： G06F19/3462 , A61J7/0053 , A61J7/0418 , A61J7/0436 , A61J7/0445 , A61J7/0463 , A61J2200/30 , A61J2205/50 , A61J2205/60 , G06F19/00 , G06K19/07762 , G06K19/07783 , H04B5/0062
摘要： Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
摘要翻译： 提供了用于口腔粘膜给小剂量药物剂型口服粘膜的分配装置和系统。 分配装置可以是单剂量施用器（SDA），或者包括用于患者识别的装置的机电装置，例如腕部佩戴的RFID标签和环形双向天线以及锁定特征。
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5.发明申请Small Volume Oral Transmucosal Dosage Forms Containing Sufentanil for Treatment of Pain 有权含有舒芬太尼治疗疼痛的小体积口腔粘膜粘膜剂量形式公开(公告)号：US20100105735A1
公开(公告)日：2010-04-29
申请号：US12521949
申请日：2007-12-28
申请人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
发明人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
IPC分类号： A61K31/4535 , A61P25/00
CPC分类号： A61K9/006 , A61J7/0038 , A61J7/0053 , A61J7/0418 , A61J7/0445 , A61J7/0481 , A61J2200/30 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2072 , A61K31/4535 , A61M15/00 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M2205/276 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/583 , A61M2205/6054 , A61M2205/609 , A61M2209/086 , G07C9/00031 , G07F17/0092 , H01Q1/2208
摘要： Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
摘要翻译： 公开了用于向受试者的口腔粘膜施用小体积舒芬太尼的药物剂型的组合物，方法和系统。
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6.发明授权Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms 有权移动用于口服经粘膜剂型的给药的分配装置的递送部件的方法公开(公告)号：US08499966B2
公开(公告)日：2013-08-06
申请号：US12521983
申请日：2007-12-28
申请人： Pamela Palmer , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards , Edmond Chiu , Thomas Schreck , Stelios Tzannis , Larry Hamel
发明人： Pamela Palmer , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards , Edmond Chiu , Thomas Schreck , Stelios Tzannis , Larry Hamel
CPC分类号： A61K9/006 , A61J7/0038 , A61J7/0053 , A61J7/0418 , A61J7/0445 , A61J7/0481 , A61J2200/30 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2072 , A61K31/4535 , A61M15/00 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M2205/276 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/583 , A61M2205/6054 , A61M2205/609 , A61M2209/086 , G07C9/00031 , G07F17/0092 , H01Q1/2208
摘要： A method of administering small, bioadhesive drug tablets includes moving an end portion of a delivery member. A surface of the delivery member can be positioned to prevent movement of the drug tablet from a tablet cartridge channel to a delivery passage of a delivery device when the end portion of the delivery member is in a first stopped position. The end portion of the delivery member can be moved to a second position within the delivery passage such that the tablet cartridge channel is in communication with the delivery passage. The drug tablet can be conveyed into the delivery passage via the tablet cartridge channel. The end portion of the delivery member can be moved to a third position within the delivery passage to convey the drug tablet through an exit opening of the delivery device.
摘要翻译： 施用小的生物粘附药物片剂的方法包括移动递送构件的端部。 当输送构件的端部处于第一停止位置时，输送构件的表面可以被定位成防止药片从药片通道移动到输送装置的输送通道。 输送构件的端部可以移动到输送通道内的第二位置，使得药片通道与输送通道连通。 药片可经由药片通道输送到输送通道中。 输送构件的端部可以移动到输送通道内的第三位置，以将药片输送通过输送装置的出口。
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7.发明授权Methods for administering small volume oral transmucosal dosage forms using a dispensing device 有权使用分配装置施用小体积口腔粘膜剂型的方法公开(公告)号：US09289583B2
公开(公告)日：2016-03-22
申请号：US11980216
申请日：2007-10-30
申请人： Pamela Palmer , Andrew I Poutiatine , Charles Rampersaud , Bruce Edwards , Edmond Chiu , Thomas Schreck , Stelios Tzannis , Larry Hamel
发明人： Pamela Palmer , Andrew I Poutiatine , Charles Rampersaud , Bruce Edwards , Edmond Chiu , Thomas Schreck , Stelios Tzannis , Larry Hamel
IPC分类号： A61M31/00
CPC分类号： A61M31/00
摘要： Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
摘要翻译： 公开了使用装置向受试者的舌下粘膜施用小体积舒芬太尼药物剂型的系统和方法。 分配装置包括锁定特征和延迟或防止唾液和/或湿气进入的装置，使得装置中的药物剂型在给药前保持干燥。
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8.发明申请SMALL VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS CONTAINING SUFENTANIL FOR TREATMENT OF PAIN 有权含有舒芬太尼用于治疗疼痛的小容量口服转运剂量公开(公告)号：US20130158074A1
公开(公告)日：2013-06-20
申请号：US13555948
申请日：2012-07-23
申请人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
发明人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
IPC分类号： A61K31/4535
CPC分类号： A61K9/006 , A61J7/0038 , A61J7/0053 , A61J7/0418 , A61J7/0445 , A61J7/0481 , A61J2200/30 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2072 , A61K31/4535 , A61M15/00 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M2205/276 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/583 , A61M2205/6054 , A61M2205/609 , A61M2209/086 , G07C9/00031 , G07F17/0092 , H01Q1/2208
摘要： Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
摘要翻译： 公开了用于向受试者的口腔粘膜施用小体积舒芬太尼的药物剂型的组合物，方法和系统。
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9.发明申请Storage and Dispensing Devices for Administration of Oral Transmucosal Dosage Forms 有权用于口服粘膜粘膜剂量形式的储存和分配装置公开(公告)号：US20100137836A1
公开(公告)日：2010-06-03
申请号：US12521983
申请日：2007-12-28
申请人： Pamela Palmer , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards , Edmond Chiu , Thomas Schreck , Stelios Tzannis , Larry Hamel
发明人： Pamela Palmer , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards , Edmond Chiu , Thomas Schreck , Stelios Tzannis , Larry Hamel
CPC分类号： A61K9/006 , A61J7/0038 , A61J7/0053 , A61J7/0418 , A61J7/0445 , A61J7/0481 , A61J2200/30 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2072 , A61K31/4535 , A61M15/00 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M2205/276 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/583 , A61M2205/6054 , A61M2205/609 , A61M2209/086 , G07C9/00031 , G07F17/0092 , H01Q1/2208
摘要： Compositions, methods and systems for oral transmucosal administration of small volume sufentanil-containing drug dosage forms to a subject using a drug dispensing device are disclosed. The drug dispensing device may provide for administration of multiple doses, a single dose at a time or be a single dose applicator (SDA).
摘要翻译： 公开了使用药物分配装置向受试者口服经粘膜给药含小量舒芬太尼的药物剂型的组合物，方法和系统。 药物分配装置可以提供一次施用多个剂量，单次剂量或单剂量施用器（SDA）。
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10.发明申请Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain 有权含有舒芬太尼治疗疼痛的小体积口腔粘膜剂型公开(公告)号：US20080268023A1
公开(公告)日：2008-10-30
申请号：US11985162
申请日：2007-11-14
申请人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
发明人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
IPC分类号： A61K31/4535 , A61K9/00 , A61P29/00
CPC分类号： A61K9/006 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/7007 , A61K31/4535 , G06F19/00 , G06F19/3456 , G16H20/10
摘要： Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
摘要翻译： 公开了用于使用装置治疗疼痛的受试者的舌下粘膜给予小体积舒芬太尼药物剂型的组合物，系统和方法。
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