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    Triazole antifungal agents
    2.
    发明授权
    Triazole antifungal agents 失效
    三唑抗真菌剂

    公开(公告)号：US6124325A

    公开(公告)日：2000-09-26

    申请号：US365929

    申请日：1999-08-02

    申请人： Andrew Simon Bell ,  Peter Thomas Stephenson

    发明人： Andrew Simon Bell ,  Peter Thomas Stephenson

    IPC分类号： A61K31/00 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/44 ,  A61K31/4427 ,  A61P25/04 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  C07D249/08 ,  C07D401/06 ,  C07D401/14 ,  C07D403/10 ,  C07D521/00 ,  A61K31/4439 ,  C07D401/10

    CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

    摘要： An antifungal compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either entity, wherein X is CH or N; R.sup.1 is phenyl substituted with 1 to 3 substituents each independently selected from halo and CF.sub.3 ; R.sup.2 is (hydroxy)C.sub.1 -C.sub.4 alkyl, CONH.sub.2, S(O).sub.m (C.sub.1 -C.sub.4 alkyl), Ar or Het; m is 1 or 2; Ar is phenyl optionally monosubstituted with halo or CF.sub.3 ; and Het is a C-linked 6-membered nitrogen-containing aromatic heterocyclic group containing 1 or 2 nitrogen atoms, or a C- or N-linked 5-membered nitrogen-containing aromatic heterocyclic group containing from 2 to 4 nitrogen atoms, wherein either of said heterocyclic groups is optionally substituted with C.sub.1 -C.sub.4 alkyl or (C.sub.1 -C.sub.4 alkoxy)methyl.

    摘要翻译： 式（I）的抗真菌化合物：或其药学上可接受的盐，或任一实体的药学上可接受的溶剂合物，其中X为CH或N; R1是被1至3个独立地选自卤素和CF 3的取代基取代的苯基; R2是（羟基）C1-C4烷基，CONH2，S（O）m（C1-C4烷基），Ar或Het; m为1或2; Ar是任选被卤素或CF 3单取代的苯基; Het是含有1或2个氮原子的C连接的6元含氮芳族杂环基或含有2至4个氮原子的C或N-连接的5元含氮芳族杂环基，其中任一 的所述杂环基任选被C 1 -C 4烷基或（C 1 -C 4烷氧基）甲基取代。

    Triazole antifungal agents
    3.
    发明授权
    Triazole antifungal agents 失效
    三唑抗真菌剂

    公开(公告)号：US06376526B1

    公开(公告)日：2002-04-23

    申请号：US09452492

    申请日：1999-12-01

    申请人： Andrew Simon Bell ,  Peter Thomas Stephenson

    发明人： Andrew Simon Bell ,  Peter Thomas Stephenson

    IPC分类号： A61K314196

    CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

    摘要： An antifungal compound of formula (I): or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either entity, wherein X is CH or N; R1 is phenyl subsituted with 1 to 3 substituents each independently selected from halo and CF3; R2 is (hydroxy)C1-C4 alkyl, CONH2, S(O)m(C1-C4 alkyl), Ar or Het; m is 1 or 2; Ar is phenyl optionally monosubstituted with halo or CF3; and Het is a C-linked 6-membered nitrogen-containing aromatic heterocyclic group containing 1 or 2 nitrogen atoms, or a C- or N-linked 5-membered nitrogen-containing aromatic heterocyclic group containing from 2 to 4 nitrogen atoms, wherein either of said heterocyclic groups is optionally substituted with C1-C4 alkyl or (C1-C4 alkoxy)methyl.

    摘要翻译： 式（I）的抗真菌化合物：或其药学上可接受的盐，或任一实体的药学上可接受的溶剂合物，其中X为CH或N; R1是被1至3个取代基取代的苯基，各自独立地选自卤素和CF 3; R2是（羟基）C1-C4烷基，CONH2，S（O）m（C1-C4烷基），Ar或Het; m为1或2; Ar是任选被卤素或CF 3单取代的苯基; Het是含有1或2个氮原子的C连接的6元含氮芳族杂环基或含有2至4个氮原子的C或N-连接的5元含氮芳族杂环基，其中任一 的所述杂环基任选被C 1 -C 4烷基或（C 1 -C 4烷氧基）甲基取代。