公开(公告)号：US07672424B2

公开(公告)日：2010-03-02

申请号：US11575902

申请日：2005-09-22

申请人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J. Heuscher

发明人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J. Heuscher

IPC分类号： A61B6/00

CPC分类号： G06T11/006

摘要： A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.

摘要翻译： 放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。 基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹 （12）。 基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

公开(公告)号：US20090202036A1

公开(公告)日：2009-08-13

申请号：US11575902

申请日：2005-09-22

申请人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J, Heuscher

发明人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J, Heuscher

IPC分类号： H05G1/60 ,  G06K9/00

CPC分类号： G06T11/006

摘要： A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.

摘要翻译： 放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。 基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹 （12）。 基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

公开(公告)号：US20080273655A1

公开(公告)日：2008-11-06

申请号：US11570896

申请日：2005-06-24

申请人： Tim Nielsen ,  Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

发明人： Tim Nielsen ,  Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

IPC分类号： A61B6/00 ,  G06K9/00

CPC分类号： G06T11/006 ,  A61B6/027 ,  G06T2211/421 ,  Y10S378/901

摘要： The invention relates to an imaging method, especially a computerized tomography method, with which an object is penetrated by rays from different directions and measured values, which depend upon the intensity of the rays after penetrating the object, are acquired by a detector unit. From these measured values, an object image is reconstructed by means of back projection of measured-value-dependent back projection values. Therein, the object image is divided into overlapping, quasi-spherically symmetric image segments, each being defined by an image value and a quasi-spherically symmetric base function. Furthermore, during the back projection, the back projection values are added in proportions to the image values, wherein the proportion of a back projection value, which is added during the back projection to an image value, is dependent on a proportionality factor, which is equal to the average value of the line integrals of the base function belonging to the respective image value along those rays that have generated the measured value, on which the respective back projection value is dependent.

摘要翻译： 本发明涉及一种成像方法，特别是计算机断层摄影方法，其中物体被来自不同方向的光线穿透，并且测量值取决于穿透物体之后的光线的强度，由检测器单元获取。 从这些测量值，通过背投影测量值依赖的反投影值重建对象图像。 其中，对象图像被划分为重叠的准球形对称图像片段，每个片段由图像值和准球形对称的基本功能定义。 此外，在背投影期间，反投影值以与图像值成比例的方式相加，其中在后投影中添加的反投影值与图像值的比例取决于比例因子，即比例因子 等于属于相应图像值的基本功能的线积分的平均值，沿着相应的背投影值依赖于已经产生测量值的那些射线。

公开(公告)号：US07570731B2

公开(公告)日：2009-08-04

申请号：US11570896

申请日：2005-06-24

申请人： Tim Nielsen ,  Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

发明人： Tim Nielsen ,  Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

IPC分类号： A61B6/03

CPC分类号： G06T11/006 ,  A61B6/027 ,  G06T2211/421 ,  Y10S378/901

摘要： The invention relates to an imaging method, especially a computerized tomography method, with which an object is penetrated by rays from different directions and measured values, which depend upon the intensity of the rays after penetrating the object, are acquired by a detector unit. From these measured values, an object image is reconstructed by means of back projection of measured-value-dependent back projection values. Therein, the object image is divided into overlapping, quasi-spherically symmetric image segments, each being defined by an image value and a quasi-spherically symmetric base function. Furthermore, during the back projection, the back projection values are added in proportions to the image values, wherein the proportion of a back projection value, which is added during the back projection to an image value, is dependent on a proportionality factor, which is equal to the average value of the line integrals of the base function belonging to the respective image value along those rays that have generated the measured value, on which the respective back projection value is dependent.

摘要翻译： 本发明涉及一种成像方法，特别是计算机断层摄影方法，其中物体被来自不同方向的光线穿透，并且测量值取决于穿透物体之后的光线的强度，由检测器单元获取。 从这些测量值，通过背投影测量值依赖的反投影值重建对象图像。 其中，对象图像被划分为重叠的准球形对称图像片段，每个片段由图像值和准球形对称的基本功能定义。 此外，在背投影期间，反投影值以与图像值成比例的方式相加，其中在后投影中添加的反投影值与图像值的比例取决于比例因子，即比例因子 等于属于相应图像值的基本功能的线积分的平均值，沿着相应的背投影值依赖于已经产生测量值的那些射线。

公开(公告)号：US07970195B2

公开(公告)日：2011-06-28

申请号：US11908294

申请日：2006-03-07

申请人： Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

发明人： Andy Ziegler ,  Thomas Koehler ,  Roland Proksa

IPC分类号： G06K9/00

CPC分类号： G06T11/006 ,  G06T2211/424

摘要： The invention relates to a device and a method for the iterative reconstruction of the attenuation coefficients μj in a tomographic image of an object (1) from projection measurements mi. In the update equation for μjn during the n-th iteration the backprojected error (mi−mi−(μjn)) is weighted by a voxel dependent factor Formula (I). Such a voxel dependent update may particularly be included in the algorithms of ART or ML.

摘要翻译： 本发明涉及一种用于从投影测量mi在物体（1）的断层图像中迭代重建衰减系数μj的装置和方法。 在第n次迭代期间的μjn的更新方程中，反投影误差（mi-mi-（μjn））由体素因子因子公式（I）加权。 这种体素相关更新可以特别地包括在ART或ML的算法中。

公开(公告)号：US20100238441A1

公开(公告)日：2010-09-23

申请号：US12682939

申请日：2008-10-13

申请人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/49 ,  G01N21/00

CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

摘要翻译： 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US20100030084A1

公开(公告)日：2010-02-04

申请号：US12514589

申请日：2007-11-12

申请人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： A61B6/00 ,  G06K9/00

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  G01N21/4795 ,  G01N21/6456

摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.

公开(公告)号：US09488574B2

公开(公告)日：2016-11-08

申请号：US12682939

申请日：2008-10-13

申请人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/47 ,  A61B5/00 ,  G01N21/17

CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

摘要翻译： 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US08861674B2

公开(公告)日：2014-10-14

申请号：US13509840

申请日：2010-12-10

申请人： Thomas Koehler ,  Roland Proksa ,  Ewald Roessl

发明人： Thomas Koehler ,  Roland Proksa ,  Ewald Roessl

IPC分类号： A61B6/00 ,  A61B6/03 ,  G01N23/04 ,  G06T11/00

CPC分类号： A61B6/032 ,  A61B6/469 ,  A61B6/542 ,  G01N23/046 ,  G01N2223/419 ,  G06T11/005 ,  Y10S378/901

摘要： The invention relates to a computed tomography apparatus for imaging an object. The computed tomography apparatus comprises a radiation source (2) for generating modulated radiation (4) traversing the object and a detector (6) for generating detection values depending on the radiation (4) after having traversed the object, while the radiation source (2) and the object are moved relative to each other. A weight providing unit (14) provides modulation weights for weighting the detection values depending on the modulation of the radiation (4) and a reconstruction unit (15) reconstructs an image of the object, wherein the detection values are weighted based on the provided modulation weights and an image of the object is reconstructed from the weighted detection values. This can allow to optimize the dose application to the object by modulating the radiation accordingly, wherein the reconstructed images still have a high quality.

摘要翻译： 本发明涉及一种用于对物体成像的计算机断层摄影装置。 计算机断层摄影装置包括用于产生经过物体的调制辐射（4）的辐射源（2）和用于在穿过物体之后产生取决于辐射（4）的检测值的检测器（6），而辐射源 ）并且对象相对于彼此移动。 权重提供单元（14）根据辐射（4）的调制提供用于对检测值进行加权的调制权重，并且重建单元（15）重建对象的图像，其中基于所提供的调制对所述检测值进行加权 从加权检测值重建对象的权重和图像。 这可以通过相应地调节辐射来优化对物体的剂量应用，其中重建的图像仍然具有高质量。

公开(公告)号：US20130251286A1

公开(公告)日：2013-09-26

申请号：US13990450

申请日：2011-11-25

申请人： Bernhard Johannes Brendel ,  Thomas Koehler ,  Holger Schmitt ,  Rolf Dieter Bippus ,  Roland Proksa

发明人： Bernhard Johannes Brendel ,  Thomas Koehler ,  Holger Schmitt ,  Rolf Dieter Bippus ,  Roland Proksa

IPC分类号： G06T11/00

CPC分类号： G06T11/003 ,  G06T11/006 ,  G06T2211/424

摘要： A method includes reconstructing measured projection data using an iterative statistical reconstruction algorithm that reduces image artifact caused by differences in variances in projections of the measured projection data used to update a voxel of the image for one or more voxels of the image. A reconstructor includes a processor that reconstructs measured projection data using an iterative statistical reconstruction algorithm that reduces or mitigates image artifact caused by differences in variances in projections used to update a voxel of the image for one or more voxels of the image. A computer readable storage medium encoded with computer executable instructions, which, when executed by a processor of a computer, cause the processor to: reduce image artifact caused by differences in variances in projections used to update a voxel of an image for one or more voxels of the image using an iterative statistical reconstruction algorithm.

摘要翻译： 一种方法包括使用迭代统计重建算法来重建测量的投影数据，所述迭代统计重构算法减少由用于更新图像的一个或多个体素的图像的体素的测量投影数据的投影方差的差异引起的图像伪像。 重构器包括使用迭代统计重建算法来重建测量的投影数据的处理器，其减少或减轻由用于更新图像的一个或多个体素的图像的体素的投影方差的差异引起的图像伪像。 一种用计算机可执行指令编码的计算机可读存储介质，其在由计算机的处理器执行时使处理器能够：减少由用于更新一个或多个体素的图像的体素的投影差异的差异引起的图像伪像 的图像使用迭代统计重建算法。