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公开(公告)号：US20120189595A1
公开(公告)日：2012-07-26
申请号：US13120727
申请日：2009-09-25
IPC分类号： A61K35/12 , C12N15/867 , A61P17/00 , C12N5/10 , C12N15/85
CPC分类号： C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/094 , C12N2510/00
摘要： The invention relates to the field of stem cells and, specially, to the reprogramming of adult somatic cells; to obtain pluripotent cells by the transfection of specific genes. Thus, the invention provides induced pluripotent stem cells (iPS) and methods of obtaining and using them.
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2.发明申请INDUCED PLURIPOTENT STEM CELL GENERATION USING TWO FACTORS AND P53 INACTIVATION 审中-公开使用两个因子和P53失活诱导的PLUIPOTETI干细胞生成公开(公告)号：US20120076762A1
公开(公告)日：2012-03-29
申请号：US13259644
申请日：2010-03-24
申请人： Teruhisa Kawamura , Jotaro Suzuki , Yunyuan V. Wang , Angel Raya , Geoffrey M. Wahl , Juan Carlos Izpisua Belmonte
发明人： Teruhisa Kawamura , Jotaro Suzuki , Yunyuan V. Wang , Angel Raya , Geoffrey M. Wahl , Juan Carlos Izpisua Belmonte
CPC分类号： C12N5/0696 , C12N2501/40 , C12N2501/602 , C12N2501/603 , C12N2501/998 , C12N2510/00
摘要： Methods and compositions are provided for, inter alia, the generation of induced pluripotent stem cells. Induced pluripotent stem cells may be generated by reprogramming and inhibition of p53. Further, useful intermediates for the generation of induced pluripotent stem cells are also provided.
摘要翻译： 提供方法和组合物，尤其是诱导多能干细胞的产生。 诱导的多能干细胞可通过重编程和抑制p53产生。 此外，还提供了用于产生诱导多能干细胞的有用中间体。
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公开(公告)号：US20110044961A1
公开(公告)日：2011-02-24
申请号：US12819059
申请日：2010-06-18
IPC分类号： A61K35/12 , C12N5/071 , C12N5/0789 , A61P43/00
CPC分类号： C12N5/0696 , A61K35/12 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/23 , C12N2501/26 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/1323 , C12N2506/11 , C12N2510/00 , C12N2533/52
摘要： Methods and compositions for the generation and use of genetically corrected induced pluripotent stem cells are provided.
摘要翻译： 提供了用于产生和使用遗传修饰的诱导多能干细胞的方法和组合物。
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4.发明申请ROBUST AND EFFICIENT DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TO MULTIPOTENT VASCULAR PROGENITORS 审中-公开人肺细胞干细胞对多种血管造血细胞的稳定和有效的分化公开(公告)号：US20140045265A1
公开(公告)日：2014-02-13
申请号：US13985852
申请日：2012-02-16
CPC分类号： C12N5/0661 , C12N5/0602 , C12N5/0634 , C12N5/0647 , C12N5/0692 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2506/02 , C12N2506/45
摘要： Provided herein are methods and compositions for generating vascular progenitor cells that can in turn be differentiated into endothelial, smooth muscle, and hematopoietic cells. The present methods provide a faster, safer, and more efficient in vitro differentiation program than existing methodologies. The differentiated cells can be used for research and therapeutic applications, such as cell transplantation.
摘要翻译： 本文提供了用于产生血管祖细胞的方法和组合物，所述血管祖细胞又可分化为内皮，平滑肌和造血细胞。 本方法提供比现有方法更快，更安全和更有效的体外分化程序。 分化细胞可用于研究和治疗应用，如细胞移植。
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公开(公告)号：US20120263689A1
公开(公告)日：2012-10-18
申请号：US13395093
申请日：2010-09-10
IPC分类号： C12N5/0775 , A61K35/12 , A61P17/02 , C12N15/87
CPC分类号： C12N5/0696 , C12N2500/90 , C12N2500/98 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1384 , C12N2510/00
摘要： Methods and compositions for generating adipose-derived induced pluripotent stem cells for humans and animals and their use are provided.
摘要翻译： 提供用于产生用于人和动物的脂肪来源的诱导性多能干细胞的方法和组合物及其用途。
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