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1.发明申请Method For Detecting Prp Using at Least One Positive Charge and/or at Least One Glycosidic Bond and a Ligand Other Than a Protein Ligand 失效用于使用至少一种正电荷和/或至少一种糖苷键和除蛋白质配体以外的配体来检测Prp的方法公开(公告)号：US20080176256A1
公开(公告)日：2008-07-24
申请号：US10583891
申请日：2005-01-19
申请人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
发明人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
IPC分类号： G01N33/00
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： The invention relates to a method for detecting PrP in a biological human or animal sample that may contain PrP. The inventive method is characterised in that it uses a molecule containing at least one positive charge and/or at least one osidic bond and a ligand other than a proteinic ligand selected from macrocyclic ligands and glycosaminoglycanes.
摘要翻译： 本发明涉及用于检测可能含有PrP的生物人或动物样品中的PrP的方法。 本发明的方法的特征在于，其使用含有至少一个正电荷和/或至少一个奥斯卡的分子和除了选自大环配体和糖胺聚糖的蛋白质配体之外的配体。
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2.发明申请Method for detecting PrP using at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand 审中-公开使用至少一种正电荷和/或至少一种糖苷键和除蛋白质配体以外的配体来检测PrP的方法公开(公告)号：US20090286269A1
公开(公告)日：2009-11-19
申请号：US12457535
申请日：2009-06-15
申请人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
发明人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
IPC分类号： C12Q1/48 , G01N33/68 , G01N33/566
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： A method for detecting PrP in a biological human or animal sample that may contain said PrP. The method is characterized in that it uses a molecule containing at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand selected from macrocyclic ligands and glycosaminoglycans.
摘要翻译： 用于检测可能含有所述PrP的生物人或动物样品中PrP的方法。 该方法的特征在于其使用含有至少一个正电荷和/或至少一个糖苷键的分子和除了选自大环配体和糖胺聚糖的蛋白质配体之外的配体。
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3.发明授权Method for detecting PrP using at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand 失效使用至少一种正电荷和/或至少一种糖苷键和除蛋白质配体以外的配体来检测PrP的方法公开(公告)号：US07566530B2
公开(公告)日：2009-07-28
申请号：US10583891
申请日：2005-01-19
申请人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
发明人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： The invention relates to a method for detecting PrP in a biological human or animal sample that may contain PrP. The inventive method is characterised in that it uses a molecule containing at least one positive charge and/or at least one osidic bond and a ligand other than a proteinic ligand selected from macrocyclic ligands and glycosaminoglycanes.
摘要翻译： 本发明涉及用于检测可能含有PrP的生物人或动物样品中的PrP的方法。 本发明的方法的特征在于，其使用含有至少一个正电荷和/或至少一个奥斯卡的分子和除了选自大环配体和糖胺聚糖的蛋白质配体之外的配体。
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公开(公告)号：US07217530B2
公开(公告)日：2007-05-15
申请号：US11148945
申请日：2005-06-09
申请人： Aly Moussa , Anthony William Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Nicoleta Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
发明人： Aly Moussa , Anthony William Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Nicoleta Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
IPC分类号： G01N33/53 , G01N33/551 , G01N33/547 , C12Q1/37 , C07K1/04
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S435/961 , Y10S436/823 , Y10S530/807
摘要： A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.
摘要翻译： 检测负责亚急性，可传染，海绵状脑病的朊病毒病原体的形式的方法，其包括游离或结合载体的大环佐剂配体（AML），其被添加到能够含有PrP sc 所得悬浮液然后与抗PrP超抗原反应，然后检测PrP的存在。
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公开(公告)号：US20070154885A1
公开(公告)日：2007-07-05
申请号：US11701334
申请日：2007-02-01
申请人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
发明人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S435/961 , Y10S436/823 , Y10S530/807
摘要： A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.
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公开(公告)号：US20060019311A1
公开(公告)日：2006-01-26
申请号：US11148945
申请日：2005-06-09
申请人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
发明人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S435/961 , Y10S436/823 , Y10S530/807
摘要： A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.
摘要翻译： 检测负责亚急性，可传染，海绵状脑病的朊病毒病原体的形式的方法，其包括游离或结合载体的大环佐剂配体（AML），其被添加到能够含有PrP sc 所得悬浮液然后与抗PrP超抗原反应，然后检测PrP的存在。
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7.发明申请Process for detecting PRPsc using an antibiotic from the family of aminoglycosides 失效使用来自氨基糖苷类家族的抗生素检测PRPsc的方法公开(公告)号：US20060014215A1
公开(公告)日：2006-01-19
申请号：US11151066
申请日：2005-06-13
申请人： Aly Moussa , Anthony Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Herve Perron , Ambroise Martin
发明人： Aly Moussa , Anthony Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Herve Perron , Ambroise Martin
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10T436/104998
摘要： A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.
摘要翻译： 用于检测或诊断PrP 的ScP浓度的浓缩过程，其中从动物或人类生物体产生或获自动物或人类生物体的组织或生物液体与 来自氨基糖苷类的抗生素，优选链霉素或其衍生物之一。 还公开了使用这种抗生素从组织或生物流体中消除PrP sc 以及用于诊断与PrP 的存在相关的病理学的试剂盒。
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8.发明授权Process for detecting PrPSC using an antibiotic from the family of aminoglycosides 失效使用来自氨基糖苷类家族的抗生素检测PrPSC的方法公开(公告)号：US07695918B2
公开(公告)日：2010-04-13
申请号：US11151066
申请日：2005-06-13
申请人： Aly Moussa , Anthony William Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Hervé Perron , Ambroise Martin
发明人： Aly Moussa , Anthony William Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Hervé Perron , Ambroise Martin
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10T436/104998
摘要： A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.
摘要翻译： 通过沉淀PrPsc来检测或诊断PrPsc的浓缩过程，其中从动物或人类生物体产生或获自动物或人类生物体的组织或生物流体与来自氨基糖苷类，优选链霉素或其衍生物之一的抗生素结合在一起。 还公开了使用这种抗生素从组织或生物流体中消除PrPsc和用于诊断与PrPsc存在相关的病理学的试剂盒。
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