公开(公告)号：US20100166772A1

公开(公告)日：2010-07-01

申请号：US12601933

申请日：2008-05-29

申请人： Annaliesa S. Anderson ,  Desmond J. Clark ,  Zhiqiang An ,  Fubao Wang ,  Susan L. Secore ,  Eberhard Durr ,  Leslie D. Cope ,  Tessie McNeely

发明人： Annaliesa S. Anderson ,  Desmond J. Clark ,  Zhiqiang An ,  Fubao Wang ,  Susan L. Secore ,  Eberhard Durr ,  Leslie D. Cope ,  Tessie McNeely

IPC分类号： A61K39/40 ,  C07K16/12 ,  C07H21/04 ,  C12N5/10 ,  C12P21/06 ,  A61K39/395 ,  C07K14/00

CPC分类号： C07K16/1271 ,  A61K2039/505 ,  C07K14/4703 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention features antigen binding proteins that bind to a region found to have an epitope that can be targeted to provide protection against S. aureus infection. The region is designated herein as the “CS-D7” target region. The CS-D7 target region provides an S. aureus ORF0657n epitope that can be targeted to reduce the likelihood or severity of an S. aureus infection.

摘要翻译： 本发明的特征在于抗原结合蛋白，其结合发现具有可靶向以提供金黄色葡萄球菌感染保护的表位的区域。 该区域在此被称为“CS-D7”目标区域。 CS-D7靶区域提供金黄色葡萄球菌ORF0657n表位，其可以靶向以降低金黄色葡萄球菌感染的可能性或严重性。

公开(公告)号：US20110091480A1

公开(公告)日：2011-04-21

申请号：US12223110

申请日：2007-01-23

申请人： Martha J. Brown ,  Annaliesa S. Anderson ,  Leslie D. Cope ,  Kathrin Ute Jansen ,  Tessie McNeely ,  Barrett R. Harvey ,  Eberhard Durr ,  Robin Ernst

发明人： Martha J. Brown ,  Annaliesa S. Anderson ,  Leslie D. Cope ,  Kathrin Ute Jansen ,  Tessie McNeely ,  Barrett R. Harvey ,  Eberhard Durr ,  Robin Ernst

IPC分类号： A61K39/40 ,  C07K16/12 ,  C07H21/04 ,  A61P31/04 ,  C12N5/10 ,  C12P21/04 ,  G01N33/567 ,  G01N33/566 ,  C12N5/16

CPC分类号： C07K16/1271 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/92

摘要： The present invention features antigen binding protein that bind an ORF0657n target region (SEQ ID NO: 1). ORF0657n is an S. aureus protein. ORF0657n target regions are provided by the mAb 1G3.BD4, mAb 2H2.BE11, mAb 13C7.BC1, and mAb 13G11.BF3 binding sites. In a lethal model challenge, mAb 2H2.BE11 and mAb 13C7.BC1 provided for increased survival against S. aureus infection. There was also protection demonstrated in an ex vivo model with either the IgG1 or the IgG2b form of mAb 2H2; and in a passive immunization murine indwelling catheter model using mAb 2H2.BE11.

摘要翻译： 本发明涉及结合ORF0657n靶区（SEQ ID NO：1）的抗原结合蛋白。 ORF0657n是金黄色葡萄球菌蛋白。 ORF0657n靶区域由mAb 1G3.BD4，mAb 2H2.BE11，mAb 13C7.BC1和mAb 13G11.BF3结合位点提供。 在致死模型挑战中，mAb 2H2.BE11和mAb 13C7.BC1提供了对金黄色葡萄球菌感染的增加的存活。 在具有mAb 2H2的IgG1或IgG2b形式的离体模型中也证实了保护作用; 并在使用mAb 2H2 .BE11的被动免疫小鼠留置导管模型中。

公开(公告)号：US20220034902A1

公开(公告)日：2022-02-03

申请号：US17299559

申请日：2019-12-06

申请人： Eberhard DURR ,  Yaping LIU ,  Zhifeng CHEN ,  Arthur FRIDMAN ,  Merck Sharp & Dohme Corp.

发明人： Eberhard Durr ,  Yaping Liu ,  Zhifeng Chen ,  Arthur Fridman

IPC分类号： G01N33/68 ,  C07K16/12

摘要： A method is described for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of antibody producing cell libraries such as B-cell and hybridoma libraries. Specifically, the method relates to application of reversed immunocapture and high resolution tandem mass spectrometry for the identification of heavy and light chain pairs of binding antibodies obtained from high throughput screens of antibody producing cell libraries.

公开(公告)号：US11566051B2

公开(公告)日：2023-01-31

申请号：US16964118

申请日：2019-01-24

申请人： Merck Sharp & Dohme Corp. ,  Lan Zhang ,  Arthur Fridman ,  Eberhard Durr ,  Andrew Bett

发明人： Lan Zhang ,  Arthur Fridman ,  Eberhard Durr ,  Andrew Bett

IPC分类号： C07K14/135 ,  A61K39/155 ,  C12N7/00 ,  A61K39/00

摘要： The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions comprising the RSV F proteins.