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公开(公告)号：US20110091480A1
公开(公告)日：2011-04-21
申请号：US12223110
申请日：2007-01-23
申请人： Martha J. Brown , Annaliesa S. Anderson , Leslie D. Cope , Kathrin Ute Jansen , Tessie McNeely , Barrett R. Harvey , Eberhard Durr , Robin Ernst
发明人： Martha J. Brown , Annaliesa S. Anderson , Leslie D. Cope , Kathrin Ute Jansen , Tessie McNeely , Barrett R. Harvey , Eberhard Durr , Robin Ernst
IPC分类号： A61K39/40 , C07K16/12 , C07H21/04 , A61P31/04 , C12N5/10 , C12P21/04 , G01N33/567 , G01N33/566 , C12N5/16
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要： The present invention features antigen binding protein that bind an ORF0657n target region (SEQ ID NO: 1). ORF0657n is an S. aureus protein. ORF0657n target regions are provided by the mAb 1G3.BD4, mAb 2H2.BE11, mAb 13C7.BC1, and mAb 13G11.BF3 binding sites. In a lethal model challenge, mAb 2H2.BE11 and mAb 13C7.BC1 provided for increased survival against S. aureus infection. There was also protection demonstrated in an ex vivo model with either the IgG1 or the IgG2b form of mAb 2H2; and in a passive immunization murine indwelling catheter model using mAb 2H2.BE11.
摘要翻译： 本发明涉及结合ORF0657n靶区（SEQ ID NO：1）的抗原结合蛋白。 ORF0657n是金黄色葡萄球菌蛋白。 ORF0657n靶区域由mAb 1G3.BD4，mAb 2H2.BE11，mAb 13C7.BC1和mAb 13G11.BF3结合位点提供。 在致死模型挑战中，mAb 2H2.BE11和mAb 13C7.BC1提供了对金黄色葡萄球菌感染的增加的存活。 在具有mAb 2H2的IgG1或IgG2b形式的离体模型中也证实了保护作用; 并在使用mAb 2H2 .BE11的被动免疫小鼠留置导管模型中。
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2.发明申请POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS 审中-公开诱导针对维生素A的保护性免疫应答的多肽公开(公告)号：US20100247561A1
公开(公告)日：2010-09-30
申请号：US12771345
申请日：2010-04-30
申请人： Annaliesa S. Anderson , Kathrin Ute Jansen , Rosemarie Kelly , Loren D. Schultz , Donna L. Montgomery , William L. McClements
发明人： Annaliesa S. Anderson , Kathrin Ute Jansen , Rosemarie Kelly , Loren D. Schultz , Donna L. Montgomery , William L. McClements
IPC分类号： A61K39/085 , A61K39/00 , A61P37/04 , A61P31/04
CPC分类号： A61K39/085 , C07K14/31 , C07K2319/35
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1, uses of such polypeptides, and expression systems for producing such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full length S. aureus polypeptide. The full-length polypeptide is referred to herein as full-length “ORF0657n”. Polypeptides containing the amino acid sequence of SEQ ID NO: 1 were found to produce a protective immune response against S. aureus.
摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽，这种多肽的用途以及用于产生此类多肽的表达系统。 SEQ ID NO：1是全长金黄色葡萄球菌多肽的截短衍生物。 全长多肽在本文中称为全长“ORF0657n”。 发现含有SEQ ID NO：1的氨基酸序列的多肽产生针对金黄色葡萄球菌的保护性免疫应答。
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公开(公告)号：US08568735B2
公开(公告)日：2013-10-29
申请号：US13379216
申请日：2010-06-22
申请人： Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Steven Morris Baker , Jasdeep Singh Nanra , Ellen Murphy , Bruce Arthur Green , Mark Edward Ruppen , Yekaterina Timofeyeva
发明人： Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Steven Morris Baker , Jasdeep Singh Nanra , Ellen Murphy , Bruce Arthur Green , Mark Edward Ruppen , Yekaterina Timofeyeva
IPC分类号： A61K39/085 , A61K39/40
CPC分类号： A61K39/085 , A61K2039/505 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , C07K16/1271 , C07K2317/21 , C07K2317/73
摘要： The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from Staphylococcus aureus. The present invention also relates to immunogenic compositions, comprising Staphylococcus aureus capsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects against Staphylococcus aureus using immunogenic compositions of the Staphylococcus aureus polypeptides and capsule polysaccharides.
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公开(公告)号：US09757443B2
公开(公告)日：2017-09-12
申请号：US13295030
申请日：2011-11-11
申请人： Annaliesa Sybil Anderson , Kathrin Ute Jansen , Mark E. Ruppen , Justin Keith Moran , Susan Kay Hoiseth
发明人： Annaliesa Sybil Anderson , Kathrin Ute Jansen , Mark E. Ruppen , Justin Keith Moran , Susan Kay Hoiseth
IPC分类号： A61K39/095 , C07K14/22 , A61K39/00
CPC分类号： A61K39/095 , A61K2039/55505 , A61K2039/55577 , C07K14/22
摘要： The present invention relates to compositions including an isolated non-pyruvylated non-lipidated ORF2086 polypeptide, and methods thereof. In an exemplary embodiment, the compositions described herein are immunogenic. The present invention further relates to compositions that elicit a bactericidal immune response in a mammal against an ORF2086 subfamily B polypeptide from serogroup B Neisseria meningitidis, and methods related thereto.
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5.发明申请COMPOSITIONS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN AND METHODS THEREOF 有权关于一种突变型脱落孢子虫毒素的组合物及其方法公开(公告)号：US20120269841A1
公开(公告)日：2012-10-25
申请号：US13451631
申请日：2012-04-20
申请人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Terri L. Mininni , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
发明人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Terri L. Mininni , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
CPC分类号： C07K14/33 , A61K39/08 , C07K16/1282 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N9/1051 , C12N9/99 , C12N15/74
摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
摘要翻译： 一方面，本发明涉及包含突变型艰难梭菌毒素A和/或突变型艰难梭菌毒素B的免疫原性组合物。每种突变毒素包括具有至少一个突变的葡糖基转移酶结构域和具有至少一个突变的半胱氨酸蛋白酶结构域 突变，相对于相应的野生型艰难梭菌毒素。 突变毒素还可以包括至少一个化学交联的氨基酸。 在另一方面，本发明涉及结合所述免疫原性组合物的抗体或其结合片段。 在另外的方面，本发明涉及编码前述任何一种的分离的核苷酸序列，以及任何上述组合物的使用方法。
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6.发明申请NON-LIPIDATED VARIANTS OF NEISSERIA MENINGITIDIS ORF2086 ANTIGENS 审中-公开NEISSERIA MENINGITIDIS ORF2086抗体的非脂肪变异公开(公告)号：US20120093852A1
公开(公告)日：2012-04-19
申请号：US13295030
申请日：2011-11-11
申请人： Annaliesa Sybil Anderson , Kathrin Ute Jansen , Mark E. Ruppen , Justin Keith Moran , Susan Kay Hoiseth
发明人： Annaliesa Sybil Anderson , Kathrin Ute Jansen , Mark E. Ruppen , Justin Keith Moran , Susan Kay Hoiseth
IPC分类号： A61K39/095 , A61P37/04 , C07K14/22
CPC分类号： A61K39/095 , A61K2039/55505 , A61K2039/55577 , C07K14/22
摘要： The present invention relates to compositions including an isolated non-pyruvylated non-lipidated ORF2086 polypeptide, and methods thereof. In an exemplary embodiment, the compositions described herein are immunogenic. The present invention further relates to compositions that elicit a bactericidal immune response in a mammal against an ORF2086 subfamily B polypeptide from serogroup B Neisseria meningitidis, and methods related thereto.
摘要翻译： 本发明涉及包含分离的非丙酮酸化的非脂化的非脂化ORF2086多肽的组合物及其方法。 在一个示例性实施方案中，本文所述的组合物是免疫原性的。 本发明还涉及在哺乳动物中引起来自血清组B脑膜炎奈瑟氏球菌的ORF2086亚家族B多肽的杀细菌免疫应答的组合物及其相关方法。
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公开(公告)号：US20100041097A1
公开(公告)日：2010-02-18
申请号：US11921903
申请日：2006-06-09
申请人： Janine Bryan , Michelle K. Brownlow , Loren D. Schultz , Maria C. Losada , Kathrin Ute Jansen , Myra Kurtz , Stuart Kurtz
发明人： Janine Bryan , Michelle K. Brownlow , Loren D. Schultz , Maria C. Losada , Kathrin Ute Jansen , Myra Kurtz , Stuart Kurtz
CPC分类号： C12N15/81
摘要： The present invention provides a synthetic gene control region which comprises a gene regulatory sequence comprising a binding site for a gene regulatory protein of a yeast strain, and a promoter from filamentous fungal strain located downstream of the gene regulatory sequence; wherein the promoter can be recognized by the general transcription factors and RNA polymerase of the yeast strain; wherein the gene regulatory sequence is capable of regulating transcription initiated by the filamentous fungal promoter in the yeast strain.
摘要翻译： 本发明提供合成基因控制区，其包含基因调控序列，其包含酵母菌株的基因调节蛋白的结合位点和位于基因调控序列下游的丝状真菌菌株的启动子; 其中所述启动子可被酵母菌株的一般转录因子和RNA聚合酶识别; 其中所述基因调控序列能够调节由所述酵母菌株中丝状真菌启动子引发的转录。
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公开(公告)号：US06841157B2
公开(公告)日：2005-01-11
申请号：US10332553
申请日：2001-07-03
IPC分类号： C12N15/09 , C07K14/025 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/02 , C12N15/37 , C12N15/86 , C12Q1/68 , C12Q1/70 , A61K39/12
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/20021 , C12N2710/20022 , C12N2710/20043 , C12N2710/20044 , C12N2800/108
摘要： This invention relates to infectious chimeric papillomaviruses, and especially those where the early genes are from human papillomavirus (HPV) 18, and the late genes are from another HPV. Also presented are methods of culturing the virus in raft cell cultures, and to assays utilizing these chimeric viruses.
摘要翻译： 本发明涉及感染性嵌合乳头瘤病毒，特别是早期基因来自人乳头状瘤病毒（HPV）18，晚期基因来自另一HPV的那些。 还提出了在筏细胞培养物中培养病毒的方法以及利用这些嵌合病毒的测定法。
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9.发明授权Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions 有权用于制备金黄色葡萄球菌血清型5和8的荚膜多糖缀合物免疫原性组合物的组合物和方法公开(公告)号：US09125951B2
公开(公告)日：2015-09-08
申请号：US13379291
申请日：2010-06-22
申请人： Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
发明人： Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
IPC分类号： A61K39/00 , A61K39/085 , A61K39/385 , A61K47/48
CPC分类号： A61K39/085 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , A61K2039/627 , A61K2039/64 , C08B37/00
摘要： The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).
摘要翻译： 本发明涉及包含金黄色葡萄球菌血清型5和8个与载体蛋白缀合的荚膜多糖的免疫原性缀合物及其制备和使用方法。 制备本发明的免疫原性缀合物的方法包括使用涉及1,1-碳基 - 二-1,2,4-三唑（CDT）或3-（2-吡啶基二硫代磷酸酯）的共轭化学，使荚膜多糖与载体蛋白共价共轭 ） - 丙酰肼（PDPH）。
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公开(公告)号：US20120107327A1
公开(公告)日：2012-05-03
申请号：US13379216
申请日：2010-06-22
申请人： Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Steven Morris Baker , Jasdeep Singh Nanra , Ellen Murphy , Bruce Arthur Green , Mark Edward Ruppen , Yekaterina Timofeyeva
发明人： Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Steven Morris Baker , Jasdeep Singh Nanra , Ellen Murphy , Bruce Arthur Green , Mark Edward Ruppen , Yekaterina Timofeyeva
IPC分类号： A61K39/085 , A61P31/04 , A61P37/04 , A61K39/385 , A61K39/40
CPC分类号： A61K39/085 , A61K2039/505 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , C07K16/1271 , C07K2317/21 , C07K2317/73
摘要： The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from Staphylococcus aureus. The present invention also relates to immunogenic compositions, comprising Staphylococcus aureus capsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects against Staphylococcus aureus using immunogenic compositions of the Staphylococcus aureus polypeptides and capsule polysaccharides.
摘要翻译： 本发明涉及包含来自金黄色葡萄球菌的多肽和多糖的免疫原性组合物。 本发明还涉及包含与载体蛋白缀合的金黄色葡萄球菌胶囊多糖的免疫原性组合物。 此外，本发明涉及使用金黄色葡萄球菌多肽和胶囊多糖的免疫原性组合诱导针对金黄色葡萄球菌的受试者的免疫应答的方法。
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