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    Benzodiazepine cgrp receptor antagonists
    3.
    发明申请
    Benzodiazepine cgrp receptor antagonists 有权
    苯二氮卓cgrp受体拮抗剂

    公开(公告)号：US20060148790A1

    公开(公告)日：2006-07-06

    申请号：US10562298

    申请日：2004-06-24

    申请人： Christopher Burgey ,  Craig Stump ,  Theresa Williams

    发明人： Christopher Burgey ,  Craig Stump ,  Theresa Williams

    IPC分类号： A61K31/5513 ,  C07D403/14

    CPC分类号： C07D401/14

    摘要： The present invention is directed to compounds of Formula I: (where variables R1, R2, R3, R6, R7, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 本发明涉及式I化合物：其中R 1，R 2，R 3，R 6， G，J，W，X和Y如本文所定义），其可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病， 如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    Cgrp receptor antagonists
    4.
    发明申请
    Cgrp receptor antagonists 有权
    Cgrp受体拮抗剂

    公开(公告)号：US20060194783A1

    公开(公告)日：2006-08-31

    申请号：US10551830

    申请日：2004-04-09

    申请人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

    发明人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

    IPC分类号： A61K31/554 ,  A61K31/55 ,  A61K31/553 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14

    CPC分类号： C07D401/14 ,  C07D413/14

    摘要： The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 本发明涉及用作CGRP拮抗剂的式I和式II化合物（其中变量R1，R2，R3，R4，R6，A，B，G，J，W，X和Y如本文所定义） 受体，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    Cgrp Receptor Antagonists
    6.
    发明申请
    Cgrp Receptor Antagonists 有权
    Cgrp受体拮抗剂

    公开(公告)号：US20080070899A1

    公开(公告)日：2008-03-20

    申请号：US11664905

    申请日：2005-10-05

    申请人： Christopher Burgey ,  James Deng ,  Craig Potteiger ,  Theresa Williams

    发明人： Christopher Burgey ,  James Deng ,  Craig Potteiger ,  Theresa Williams

    IPC分类号： C07D401/14 ,  A61K31/55 ,  A61P25/06

    CPC分类号： C07D491/20 ,  C07D471/10 ,  C07D471/20 ,  C07D491/10

    摘要： The present invention is directed to compounds of Formula I: Formula I: I and Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 本发明涉及式I的化合物：式I：I和式II：（其中R 1，R 2，R 3， >，R 4，A，B，J，Q，T，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    CGRP receptor antagonists
    7.
    发明申请
    CGRP receptor antagonists 有权
    CGRP受体拮抗剂

    公开(公告)号：US20070225272A1

    公开(公告)日：2007-09-27

    申请号：US11724066

    申请日：2007-03-14

    申请人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

    发明人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

    IPC分类号： A61K31/55 ,  C07D401/14

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 本发明涉及式I化合物和式II化合物：其中R 1，R 2，R 3，R 3， A，B，G，J，Q，T，U，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    Benodiazepine spirohydantoin cgrp receptor antagonists
    10.
    发明申请
    Benodiazepine spirohydantoin cgrp receptor antagonists 有权
    苯二氮卓螺螺蛋白cgrp受体拮抗剂

    公开(公告)号：US20060189600A1

    公开(公告)日：2006-08-24

    申请号：US10547228

    申请日：2004-03-10

    申请人： Ian Bell ,  Samuel Graham ,  Theresa Williams ,  Craig Stump

    发明人： Ian Bell ,  Samuel Graham ,  Theresa Williams ,  Craig Stump

    IPC分类号： A61K31/5513 ,  C07D403/02

    CPC分类号： C07D403/12 ,  C07D235/02

    摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。