摘要:
There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要:
There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要:
The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
摘要:
There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要:
Customized articles of footwear are produced by defining options that can be selected by a customer when submitting a custom order. These options typically include model options, functional options, and aesthetic options. These options are created by a design source, such as a shoe designer within a particular market, and presented to the customer when making the order. Upon a customer selecting one or more of the options at a user interface, the selected options are converted to specifications associated with the order. A work-load engine is employed to generate, based on the specifications, a work order that includes a dataflow for selecting appropriate stations on a manufacturing floor to participate in a manufacturing process, and a workflow for instructing each of the appropriate stations to perform a sequence of operations, within the manufacturing process, that result in fabricating individual components of the article of footwear according to the order.
摘要:
A method for producing a regionalized-firmness midsole utilizing a heat press, and a description of the resultant product, are provided. Initially, the method involves providing a plurality of pre-formed phylon biscuits. Typically, the plurality of biscuits includes at least a first biscuit that has a first density and a second biscuit that has a second density. The method may further include the steps of arranging the biscuits into a receiving area of the heat press, and integrating the plurality of biscuits to form the midsole by activating the heat press. Integrating the biscuits includes raising the biscuits above a threshold temperature, and causing the biscuits to expand such that each of the plurality of biscuits couples with another of the biscuits to form a midsole with two or more degrees of firmness located at distributed regions thereon.
摘要:
A vapor fuel air mixture supply system for a combustion engine, whereby the mixture of air and fuel vapor is elevated in temperature prior to combustion. The liquid fuel may be vaporized in a fractionation process and further heated to enhance flame speed combustion and improve efficiency of the system.
摘要:
A vapor fuel air mixture supply system for a combustion engine, whereby the mixture of air and fuel vapor is elevated in temperature prior to combustion. The liquid fuel may be vaporized in a fractionation process and further heated to enhance flame speed combustion and improve efficiency of the system.
摘要:
A detonation chamber for a pulse detonation combustor including: a plurality of dimples disposed on at least a portion of an inner surface of the detonation chamber wherein the plurality of dimples enhance a turbulence of a fluid flow through the detonation chamber
摘要:
A pulse detonation combustor is provided with a fuel-air mixer located upstream from a detonation chamber. A fuel-air mixture exits the fuel-air mixer and enters the detonation chamber, where it is ignited by an ignition source. The flow from the fuel-air mixer passes over the surface of a center body, which extends downstream from the fuel-air mixer. The surface of the center body contains at least one turbulence generator, which imparts additional turbulence in the fuel-air mixture passing through the chamber. The turbulence generator aids in the mixing of the fuel and air of the fuel-air mixture to enhance the deflagration to detonation transition within the pulse detonation combustor.