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公开(公告)号：US20070190099A1
公开(公告)日：2007-08-16
申请号：US11696802
申请日：2007-04-05
CPC分类号： A61L27/3604 , A61L24/0084 , A61L24/0094 , A61L24/108 , A61L26/0047 , A61L26/0095 , A61L27/227 , A61L27/365 , A61L27/3847 , A61L27/3865 , A61L27/46 , A61L27/48
摘要： A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues. The fibroin solutions and suspensions are particularly useful for methods of tissue construction and/or repair.
摘要翻译： 使用丝心蛋白溶液和悬浮液制备生物活性物质，其设计用于支持骨骼和身体的其他组织的构造，修复，再生或增加。 可以注射丝心蛋白溶液，悬浮液和复合材料以填充空腔或替代缺失的组织。 注射后，材料可以产生能够在降解的同时促进组织再生的支架。 注射丝心蛋白溶液，悬浮液和复合材料的能力可以减少用于更换或修复骨骼和其他组织的许多类型的外科手术的需要。 丝心蛋白溶液和悬浮液对于组织结构和/或修复的方法特别有用。
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公开(公告)号：US20120040907A1
公开(公告)日：2012-02-16
申请号：US13280411
申请日：2011-10-25
CPC分类号： A61L27/3604 , A61L24/0084 , A61L24/0094 , A61L24/108 , A61L26/0047 , A61L26/0095 , A61L27/227 , A61L27/365 , A61L27/3847 , A61L27/3865 , A61L27/46 , A61L27/48
摘要： A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues. The fibroin solutions and suspensions are particularly useful for methods of tissue construction and/or repair.
摘要翻译： 使用丝心蛋白溶液和悬浮液制备生物活性物质，其设计用于支持骨骼和身体的其他组织的构造，修复，再生或增加。 可以注射丝心蛋白溶液，悬浮液和复合材料以填充空腔或替代缺失的组织。 注射后，材料可以产生能够在降解的同时促进组织再生的支架。 注射丝心蛋白溶液，悬浮液和复合材料的能力可以减少用于更换或修复骨骼和其他组织的许多类型的外科手术的需要。 丝心蛋白溶液和悬浮液对于组织结构和/或修复的方法特别有用。
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公开(公告)号：US08071118B2
公开(公告)日：2011-12-06
申请号：US11696802
申请日：2007-04-05
IPC分类号： A61F2/02
CPC分类号： A61L27/3604 , A61L24/0084 , A61L24/0094 , A61L24/108 , A61L26/0047 , A61L26/0095 , A61L27/227 , A61L27/365 , A61L27/3847 , A61L27/3865 , A61L27/46 , A61L27/48
摘要： A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues. The fibroin solutions and suspensions are particularly useful for methods of tissue construction and/or repair.
摘要翻译： 使用丝心蛋白溶液和悬浮液制备生物活性物质，其设计用于支持骨骼和身体的其他组织的构造，修复，再生或增加。 可以注射丝心蛋白溶液，悬浮液和复合材料以填充空腔或替代缺失的组织。 注射后，材料可以产生能够在降解的同时促进组织再生的支架。 注射丝心蛋白溶液，悬浮液和复合材料的能力可以减少用于更换或修复骨骼和其他组织的许多类型的外科手术的需要。 丝心蛋白溶液和悬浮液对于组织结构和/或修复的方法特别有用。
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公开(公告)号：US07285637B2
公开(公告)日：2007-10-23
申请号：US10398252
申请日：2001-09-28
CPC分类号： A61L27/3839 , A61L27/225 , A61L27/3604 , A61L27/3683 , D01D5/40 , D01F4/02 , D04H1/4266 , D04H3/015
摘要： A process for producing non-woven silk fiber fabrics comprises the following steps: a) obtaining silk fibroin, for example either from silk cocoons, or silk textiles or waste silk; b) removing the sericin layer covering the silk fibroin fibers, when present; c) breaking the disulfide bonds between heavy (350 kDa) and light (27 kDa) chains of silk fibroin in order to obtain the production of chain fragments which serve as a specific cellular recognition sites promoting the attachment and growth of cells, d) homogenising of the material resulting from step c).
摘要翻译： 制造无纺丝纤维织物的方法包括以下步骤：a）获得例如丝茧或丝织物或废丝的丝素蛋白; b）当存在时去除覆盖丝心蛋白纤维的丝氨酸层; c）打破丝网蛋白重链（350kDa）和轻（27kDa）链之间的二硫键，以获得促成细胞附着和生长的特异性细胞识别位点的链片段的产生，d）均质化 由步骤c）得到的材料。
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5.发明授权Bioactive materials, methods of making bioactive materials and method of use thereof 失效生物活性材料，制备生物活性材料的方法及其使用方法公开(公告)号：US07727542B2
公开(公告)日：2010-06-01
申请号：US10281096
申请日：2002-10-25
CPC分类号： A61L27/3604 , A61L24/0084 , A61L24/0094 , A61L24/108 , A61L26/0047 , A61L26/0095 , A61L27/227 , A61L27/365 , A61L27/3847 , A61L27/3865 , A61L27/46 , A61L27/48
摘要： A bioactive material is made using fibroin solutions and suspensions that can be used alone or as a composite with particles such as core/shell particles. The material is designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The solutions and suspensions can be loaded with core/shell-type particles comprising inorganic core materials that are coated with biodegradable polymers with an outer coating of a calcium phosphate precursor. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The degradation of the particles, when present, can generate additional porosity within the scaffold and release other compounds in a controlled manner to enhance growth and activation of the cells necessary for tissue repair. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues.
摘要翻译： 使用丝心蛋白溶液和悬浮液制备生物活性物质，其可以单独使用或作为与颗粒如核/壳颗粒的复合物使用。 该材料设计用于支撑身体的骨骼和其他组织的构造，修复，再生或增强。 溶液和悬浮液可以装载有包含无机芯材料的芯/壳型颗粒，其中涂覆有具有磷酸钙前体外涂层的可生物降解的聚合物。 可以注射丝心蛋白溶液，悬浮液和复合材料以填充空腔或替代缺失的组织。 注射后，材料可以产生能够在降解的同时促进组织再生的支架。 当存在时，颗粒的降解可以在支架内产生额外的孔隙，并以受控的方式释放其它化合物以增强组织修复所必需的细胞的生长和活化。 注射丝心蛋白溶液，悬浮液和复合材料的能力可以减少用于更换或修复骨骼和其他组织的许多类型的外科手术的需要。
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公开(公告)号：US5814146A
公开(公告)日：1998-09-29
申请号：US765427
申请日：1996-12-31
CPC分类号： C04B40/005 , C04B20/0048
摘要： The invention concerns a MDF cement material showing better impact strength meant as an increase in the breaking total energy, by fibers addition.
摘要翻译： PCT No.PCT / EP95 / 02586 Sec。 371日期1996年12月31日第 102（e）日期1996年12月31日PCT提交1995年7月4日PCT公布。 出版物WO96 / 01234 日期1996年1月18日本发明涉及一种MDF水泥材料，其显示出更好的抗冲击强度，意味着通过纤维添加来提高断裂总能量。
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