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1.发明申请Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers 有权噻唑和噻吩类似物及其在治疗自身免疫性疾病和癌症中的应用公开(公告)号：US20120283268A1
公开(公告)日：2012-11-08
申请号：US13524225
申请日：2012-06-15
申请人： Anthony Giordano , Kamala K. Vasu , Hardik M. Thakar , Rajan S. Giri , Vasudevan Sudarsanam , Swapnil G. Yerande , Gajanan S. Inamdar
发明人： Anthony Giordano , Kamala K. Vasu , Hardik M. Thakar , Rajan S. Giri , Vasudevan Sudarsanam , Swapnil G. Yerande , Gajanan S. Inamdar
IPC分类号： A61K31/427 , C07D417/14 , C07D277/54 , A61K31/426 , C07D417/04 , A61K31/4439 , C07D417/12 , A61K31/496 , A61K31/517 , A61P29/00 , A61P37/00 , A61P19/02 , A61P37/06 , A61P31/00 , A61P11/00 , A61P11/06 , A61P35/00 , A61P25/00 , A61P17/06 , A61P1/00 , A61P1/16 , A61P39/06 , A61P9/10 , A61P31/12 , A61P35/02 , A61P35/04 , A61P25/28 , C07D417/06
CPC分类号： C07D333/36 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14
摘要： Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.
摘要翻译： 公开了噻唑和噻吩化合物用于治疗炎性病症，免疫炎症症状，自身免疫性疾病和癌症。 还公开了这些化合物的合成方法。
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2.发明授权Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers 有权噻唑和噻吩类似物，以及它们在治疗自身免疫性疾病和癌症中的应用公开(公告)号：US08829014B2
公开(公告)日：2014-09-09
申请号：US13524225
申请日：2012-06-15
申请人： Anthony Giordano , Kamala K. Vasu , Hardik M. Thakar , Rajan S. Giri , Vasudevan Sudarsanam , Swapnil G. Yerande , Gajanan S. Inamdar
发明人： Anthony Giordano , Kamala K. Vasu , Hardik M. Thakar , Rajan S. Giri , Vasudevan Sudarsanam , Swapnil G. Yerande , Gajanan S. Inamdar
IPC分类号： A61K31/517 , C07D417/02
CPC分类号： C07D333/36 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14
摘要： Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.
摘要翻译： 公开了噻唑和噻吩化合物用于治疗炎性病症，免疫炎症症状，自身免疫性疾病和癌症。 还公开了这些化合物的合成方法。
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3.发明授权Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers 有权噻唑和噻吩类似物，以及它们在治疗自身免疫性疾病和癌症中的应用公开(公告)号：US08217037B2
公开(公告)日：2012-07-10
申请号：US12296173
申请日：2007-04-05
申请人： Anthony Giordano , Kamala K. Vasu , Hardik M. Thakar , Rajan S. Giri , Swapnil G. Yerande , Gajanan S. Inamdar , Vasudevan Sudarsanam
发明人： Anthony Giordano , Kamala K. Vasu , Hardik M. Thakar , Rajan S. Giri , Swapnil G. Yerande , Gajanan S. Inamdar , Vasudevan Sudarsanam
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D333/36 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14
摘要： Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.
摘要翻译： 公开了噻唑和噻吩化合物用于治疗炎性病症，免疫炎症症状，自身免疫性疾病和癌症。 还公开了这些化合物的合成方法。
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4.发明申请Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers 有权噻唑和噻吩类似物及其在治疗自身免疫性疾病和癌症中的应用公开(公告)号：US20090306073A1
公开(公告)日：2009-12-10
申请号：US12296173
申请日：2007-04-05
申请人： Anthony Giordano , Kamala K. Vasu , Hardik M. Thakar , Rajan S. Giri , Swapnil G. Yerande , Gajanan S. Inamdar , Jitendra C. Kaila , H. Padh Ahmedabad , Vasudevan Sudarsanam
发明人： Anthony Giordano , Kamala K. Vasu , Hardik M. Thakar , Rajan S. Giri , Swapnil G. Yerande , Gajanan S. Inamdar , Jitendra C. Kaila , H. Padh Ahmedabad , Vasudevan Sudarsanam
IPC分类号： A61K31/5377 , C07D409/14 , A61K31/497 , C07D415/00 , A61K31/517 , C07D277/00 , A61K31/425
CPC分类号： C07D333/36 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14
摘要： Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.
摘要翻译： 公开了噻唑和噻吩化合物用于治疗炎性病症，免疫炎症症状，自身免疫性疾病和癌症。 还公开了这些化合物的合成方法。
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5.发明授权Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof 失效可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US08691864B2
公开(公告)日：2014-04-08
申请号：US13559186
申请日：2012-07-26
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/40
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。 本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。 已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。
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6.发明申请Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 有权可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US20110021594A1
公开(公告)日：2011-01-27
申请号：US12841888
申请日：2010-07-22
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。 本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。 已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。
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公开(公告)号：US08846978B2
公开(公告)日：2014-09-30
申请号：US13262739
申请日：2010-04-02
CPC分类号： H01L51/5203 , C07F9/3808 , H01L51/004 , H01L51/5088
摘要： In some embodiments, the inventions described herein relate to a composition of matter comprising a molecule having the structure: wherein: independently at each occurrence, R1 is a halogen, a alkyl group, a heteroalkyl group, an aryl group, or a heteroaryl group; R2 comprises from 3 to 30 CH2— groups, n=0-5, m=0-5, q=1-3, and R2 comprises at least one ether linkage.
摘要翻译： 在一些实施方案中，本文所述的发明涉及包含具有以下结构的分子的物质组合物：其中：在每次出现时，R 1为卤素，烷基，杂烷基，芳基或杂芳基; R2包含3至30个CH 2 - 基团，n = 0-5，m = 0-5，q = 1-3，并且R 2包含至少一个醚键。
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公开(公告)号：US20140112983A1
公开(公告)日：2014-04-24
申请号：US14009927
申请日：2012-04-13
IPC分类号： A61K33/00 , A61K36/16 , A61K36/88 , A61K36/9068 , A61K36/67 , A61K31/145 , A61K36/752 , A61K36/74 , A61K36/481 , A61K36/61 , A61K36/79 , A61K45/06 , A61K36/23
CPC分类号： A61K33/00 , A23L33/10 , A23L33/105 , A23L33/16 , A61K9/4866 , A61K31/145 , A61K33/02 , A61K36/16 , A61K36/23 , A61K36/481 , A61K36/61 , A61K36/67 , A61K36/74 , A61K36/752 , A61K36/79 , A61K36/88 , A61K36/9068 , A61K45/06
摘要： The present invention relates to compositions of nitrite and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically, the method involves administering to an individual a composition of inorganic nitrite, or a pharmaceutically acceptable salt thereof, for supplementation in subjects with diabetes, peripheral artery diseases or in patients with risk factors associated with cardiovascular diseases.
摘要翻译： 本发明涉及亚硝酸盐的组合物和预防性营养补充剂和治疗性营养补充剂的方法。 具体地，该方法包括向个体施用无机亚硝酸盐或其药学上可接受的盐的组合物，用于补充患有糖尿病，外周动脉疾病的受试者或与心血管疾病相关的危险因素的患者。
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9.发明授权Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof 有权可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法公开(公告)号：US07786162B2
公开(公告)日：2010-08-31
申请号：US12357115
申请日：2009-01-21
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/40 , C07D487/00
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。 本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。 已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。
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10.发明授权Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof 有权可用于减少淀粉样蛋白前体蛋白和治疗消瘦的药剂及其使用方法公开(公告)号：US07153882B2
公开(公告)日：2006-12-26
申请号：US10415765
申请日：2001-11-02
申请人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Timothy T. Sencrant , Tada Utsuki , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Timothy T. Sencrant , Tada Utsuki , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/40 , C07D487/02 , C07D491/02
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not tocix in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译： 本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。 本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生的受试者施用这种化合物的方法，并且在广泛的剂量范围内不是曲线。 已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。
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