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公开(公告)号：US5515117A
公开(公告)日：1996-05-07
申请号：US229481
申请日：1994-04-19
申请人： Anthony J. Dziabo , Alix A. Holms , Claude B. Anger , Lin Peng
发明人： Anthony J. Dziabo , Alix A. Holms , Claude B. Anger , Lin Peng
CPC分类号： A61L12/086 , A01N25/34 , A45C11/005 , G02B1/043 , Y10S514/839 , Y10S514/84
摘要： The present invention relates to lenses, for example, contact lenses, and to contact lens cases having antimicrobial properties. More particularly, the invention relates to lenses and contact lens cases made from materials which comprise polymeric materials and effective antimicrobial components.
摘要翻译： 本发明涉及透镜，例如隐形眼镜，以及具有抗菌性能的隐形眼镜盒。 更具体地，本发明涉及由包含聚合物材料和有效抗微生物组分的材料制成的透镜和隐形眼镜盒。
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公开(公告)号：US5340583A
公开(公告)日：1994-08-23
申请号：US59025
申请日：1993-05-06
申请人： Anthony J. Dziabo , Alix A. Holmes , Claude B. Anger , John C. Baker , Lin Peng
发明人： Anthony J. Dziabo , Alix A. Holmes , Claude B. Anger , John C. Baker , Lin Peng
CPC分类号： A61L12/086 , A01N25/34 , A45C11/005 , G02B1/043 , Y10S514/839 , Y10S514/84
摘要： The present invention relates to lenses, for example, contact lenses, and to contact lens cases having antimicrobial properties. More particularly, the invention relates to lenses and contact lens cases made from materials which comprise polymeric materials and effective antimicrobial components.
摘要翻译： 本发明涉及透镜，例如隐形眼镜，以及具有抗菌性能的隐形眼镜盒。 更具体地，本发明涉及由包含聚合物材料和有效抗微生物组分的材料制成的透镜和隐形眼镜盒。
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公开(公告)号：US5736165A
公开(公告)日：1998-04-07
申请号：US277718
申请日：1994-07-20
CPC分类号： A61K39/40 , A61K33/40 , Y10S514/912 , Y10S514/914
摘要： Disclosed are in-the-eye uses of chlorine dioxide-containing compositions as effective ophthalmic antiseptics and as effective ophthalmic surgical irrigants. Surprisingly low concentrations of chlorine dioxide are effective in such applications. In addition, the presently useful compositions are ophthalmically acceptable.
摘要翻译： 公开了使用含二氧化氯的组合物作为有效的眼科防腐剂和有效的眼科手术冲洗剂。 惊人的二氧化氯浓度低是有效的。 此外，目前有用的组合物是眼科可接受的。
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4.发明授权Compositions and methods for disinfecting a contact lens and detecting the presence of an oxidative disinfectant 失效用于消毒隐形眼镜并检测氧化消毒剂的存在的组合物和方法
公开(公告)号：US5703024A
公开(公告)日：1997-12-30
申请号：US496867
申请日：1995-06-30
申请人： John Y. Park , Lin Peng , Anthony J. Dziabo
发明人： John Y. Park , Lin Peng , Anthony J. Dziabo
CPC分类号： A61L12/124 , A61L12/126 , A61L12/128
摘要： Compositions and methods useful for disinfecting a contact lens are disclosed. The present methods comprise contacting a contact lens with a liquid medium containing an effective amount of an oxidative disinfectant component at conditions to effectively disinfect the contact lens. The contacting occurs in the presence of a color indicator component which is soluble in the liquid medium and is adapted to provide a color indication of the presence of the oxidative disinfectant component in the liquid medium. The color indicator component comprises an effective amount of a transition metal component which is redox active, has an oxidized state of a first color and a reduced state of a different second color and a polyanionic component in an amount effective to inhibit the staining of the contact lens by the transition metal component.
摘要翻译： 公开了用于消毒隐形眼镜的组合物和方法。 本发明的方法包括使隐形眼镜与含有有效量的氧化消毒剂组分的液体介质接触以有效地消毒隐形眼镜。 接触发生在可溶于液体介质中的颜色指示剂组分的存在下，并且适于提供液体介质中氧化性消毒剂组分的存在的颜色指示。 颜色指示剂组分包含有效量的过氧化还原活性的过渡金属组分，具有有效抑制接触染色量的第一颜色和不同第二颜色的还原状态和聚阴离子组分的氧化状态 镜片由过渡金属部件组成。
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5.发明授权Compositions and methods for disinfecting a contact lens and detecting the presence of an oxidative disinfectant 失效用于消毒隐形眼镜并检测氧化消毒剂的存在的组合物和方法
公开(公告)号：US5840250A
公开(公告)日：1998-11-24
申请号：US938493
申请日：1997-09-30
申请人： John Y. Park , Lin Peng , Anthony J. Dziabo
发明人： John Y. Park , Lin Peng , Anthony J. Dziabo
CPC分类号： A61L12/124 , A61L12/126 , A61L12/128
摘要： Compositions and methods useful for disinfecting a contact lens are disclosed. The present methods comprise contacting a contact lens with a liquid medium containing an effective amount of an oxidative disinfectant component at conditions to effectively disinfect the contact lens. The contacting occurs in the presence of a color indicator component which is soluble in the liquid medium and is adapted to provide a color indication of the presence of the oxidative disinfectant component in the liquid medium. The color indicator component comprises an effective amount of a transition metal component which is redox active, has an oxidized state of a first color and a reduced state of a different second color and a polyanionic component in an amount effective to inhibit the staining of the contact lens by the transition metal component.
摘要翻译： 公开了用于消毒隐形眼镜的组合物和方法。 本发明的方法包括使隐形眼镜与含有有效量的氧化消毒剂组分的液体介质接触以有效地消毒隐形眼镜。 接触发生在可溶于液体介质中的颜色指示剂组分的存在下，并且适于提供液体介质中氧化性消毒剂组分的存在的颜色指示。 颜色指示剂组分包含有效量的过氧化还原活性的过渡金属组分，具有有效抑制接触染色量的第一颜色和不同第二颜色的还原状态和聚阴离子组分的氧化状态 镜片由过渡金属部件组成。
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6.发明授权Compositions and methods for disinfecting contact lenses and reducing proteinaceous deposit formation 失效用于消毒隐形眼镜并减少蛋白质沉积物形成的组合物和方法
公开(公告)号：US5648074A
公开(公告)日：1997-07-15
申请号：US353782
申请日：1994-12-12
申请人： John Y. Park , Lin Peng , Anthony J. Dziabo
发明人： John Y. Park , Lin Peng , Anthony J. Dziabo
CPC分类号： A61K39/40
摘要： Compositions and methods for disinfecting contact lenses are disclosed. In one embodiment, the present compositions include a liquid medium containing chlorine dioxide precursor in an amount effective to form, when activated, a chlorine dioxide-containing composition including a contact lens disinfecting amount of chlorine dioxide. A polyanionic component, preferably a water soluble polyanionic component, is included in the composition in an amount effective to inhibit the formation of proteinaceous deposit material on a contact lens immersed in the chlorine dioxide-containing composition. Thus, effective contact lens disinfection is achieved while, at the same time, reducing the risk of forming proteinaceous deposit material on the contact lens during the disinfecting processing.
摘要翻译： 公开了消毒隐形眼镜的组合物和方法。 在一个实施方案中，本发明组合物包括含有二氧化氯前体的液体介质，其量有效地在活化时形成包含隐形眼镜消毒量的二氧化氯的含二氧化氯的组合物。 聚阴离子组分，优选水溶性聚阴离子组分，以有效抑制沉积在含二氧化氯的组合物中的隐形眼镜上形成蛋白沉积物质的量包含在组合物中。 因此，实现有效的隐形眼镜消毒，同时降低在消毒处理期间在隐形眼镜上形成蛋白沉积物质的风险。
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7.发明授权Compositions and methods for disinfecting contact lenses and preserving contact lens care products 失效用于消毒隐形眼镜和保护隐形眼镜护理产品的组合物和方法
公开(公告)号：US6024954A
公开(公告)日：2000-02-15
申请号：US692867
申请日：1996-08-02
申请人： John Y. Park , Lin Peng , Daniel P. Cafaro , Anthony J. Dziabo
发明人： John Y. Park , Lin Peng , Daniel P. Cafaro , Anthony J. Dziabo
CPC分类号： A61K39/40 , A61L12/102
摘要： Compositions for disinfecting contact lenses include a liquid medium containing a chlorite component, preferably a water soluble chlorite component, in a contact lens disinfecting amount, and a polyanionic component, preferably a water soluble polyanionic component, in an amount effective to do at least one of the following: inhibit formation of protein deposit material on a contact lens immersed in the composition; reduce the toxicity of the composition to the human eye, and reduce the damage to a contact lens caused by immersing the contact lens in the composition. The composition has a viscosity of less than 50 cps at 25.degree. C., an osmolality of at least about 200 mOsmol/kg, and preferably a pH in the range of about 6 to about 9.
摘要翻译： 用于消毒隐形眼镜的组合物包括含有接枝镜片消毒量的亚氯酸盐组分，优选水溶性亚氯酸盐组分的液体培养基和聚阴离子组分，优选水溶性聚阴离子组分，其量有效地进行至少一种 以下：抑制沉积在组合物中的隐形眼镜上形成蛋白沉积物质; 降低组合物对人眼的毒性，并减少由隐形眼镜浸入组合物而导致的隐形眼镜的损伤。 该组合物在25℃下的粘度小于50cps，至少约200mOsmol / kg的重量摩尔渗透压浓度，优选在约6至约9范围内的pH。
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公开(公告)号：US5320806A
公开(公告)日：1994-06-14
申请号：US888356
申请日：1992-05-22
申请人： Anthony J. Dziabo , Paul S. Ripley
发明人： Anthony J. Dziabo , Paul S. Ripley
CPC分类号： A61L12/102 , C11D3/0078 , C11D3/3427 , Y10S134/901 , Y10S204/06
摘要： A method of disinfecting a contact lens is disclosed and comprises placing the contact lens to be disinfected into a liquid electrolyte containing chlorine dioxide precursor, e.g., stabilized chlorine dioxide, and forming a disinfecting amount of chlorine dioxide in the liquid electrolyte by passing an electric current through the liquid electrolyte.
摘要翻译： 公开了消毒隐形眼镜的方法，包括将要消毒的隐形眼镜放置在含有二氧化氯前体（例如稳定的二氧化氯）的液体电解质中，并通过使电流通过电解液形成消毒量的二氧化氯 通过液体电解液。
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公开(公告)号：US5277901A
公开(公告)日：1994-01-11
申请号：US912862
申请日：1992-07-13
IPC分类号： A01N33/12 , A61L12/14 , A61K31/74 , A61K31/14 , A61K31/425
CPC分类号： A01N33/12 , A61L12/145 , Y10S514/912
摘要： Ophthalmic compositions, such as those used to care for contact lenses, methods of preserving such compositions, and methods for disinfecting contact lenses using certain of such compositions are disclosed. The compositions may comprise an ophthalmically acceptable, liquid aqueous medium and, included therein, an effective preserving or disinfecting amount of a combination of certain oxygen-containing ionene polymers and other antimicrobial agents, preferably certain urea components.
摘要翻译： 公开了诸如用于护理隐形眼镜的那些眼用组合物，保存这种组合物的方法以及使用某些这样的组合物来消毒隐形眼镜的方法。 组合物可以包含眼科可接受的液体水性介质，并且其中包括有效的保存或消毒量的某些含氧的紫罗烯聚合物和其它抗微生物剂，优选某些尿素组分的组合。
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10.发明授权
公开(公告)号：US5246662A
公开(公告)日：1993-09-21
申请号：US969549
申请日：1992-10-30
CPC分类号： C11D3/0078 , A01N59/00 , A61L12/102 , C11D3/3427
摘要： A method for disinfection a device such as a contact lens. The method comprises contacting the device with an aqueous liquid medium containing an effective amount of chlorine dioxide at effective disinfecting conditions. The chlorine dioxide being derived by contacting a liquid medium containing chlorine dioxide precursor with a transition metal component in an effective amount to promote the generation of chlorine dioxide from the chlorine dioxide precursor. The liquid medium further optionally containing a buffer component in an amount effective to maintain the liquid medium at a desired pH during the generation of chlorine dioxide, and to increase the rate of chlorine dioxide generation from chlorine dioxide precursor relative to a similar liquid medium without the buffer component.
摘要翻译： 一种消毒隐形眼镜等装置的方法。 该方法包括在有效的消毒条件下使装置与含有有效量的二氧化氯的含水液体介质接触。 二氧化氯是通过使含有二氧化氯前体的液体介质与过渡金属组分有效量接触而促进二氧化氯前体产生二氧化氯而得到的。 液体介质进一步任选地含有缓冲组分，其量有效地在二氧化氯产生期间将液体介质保持在所需的pH，并且相对于类似的液体介质增加二氧化氯前体相对于没有 缓冲组件。
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