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公开(公告)号：US20080087511A1
公开(公告)日：2008-04-17
申请号：US11580998
申请日：2006-10-16
IPC分类号： F16F9/04
CPC分类号： F16F9/04 , B64D2201/00 , B64G1/62
摘要： An impact attenuation bag has a height-reducing structure in the form of an internal rib that draws the upper and lower surfaces of the bag closer together, reducing the overall height of the bag when inflated as compared with the same bag in the absence of the rib. This gives the bag a flatter resting shape that provides significant performance enhancement by increasing the initial ground contact area and lowering the vehicle assembly center of gravity. As a result, the moment arm is reduced making the payload less likely to roll over. The rib may be a fabric sheet or cord laced in a criss-cross or other lacing pattern that extends from the top of the bag to the bottom.
摘要翻译： 冲击衰减袋具有内肋形式的高度减小结构，其将袋的上表面和下表面更靠近在一起，与没有相同袋时的袋相比，在膨胀时减小袋的整体高度 肋骨。 这使得袋子更平坦的休息形状，通过增加初始接地面积和降低车辆组件的重心来提供显着的性能提升。 因此，力矩臂减小，使得有效载荷不太可能翻滚。 肋条可以是以从十字形或其他带状图案的织物片或绳子，其从袋的顶部延伸到底部。
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公开(公告)号：US20140142993A1
公开(公告)日：2014-05-22
申请号：US13934037
申请日：2013-07-02
申请人： John Sanders
发明人： John Sanders
IPC分类号： G06Q10/02
摘要： A method of booking talent is provided, comprising: storing a plurality of talent files on a data storage system, each of the talent files being categorized based on select criteria, and wherein each talent file contains talent information associated with one of a plurality of performing artists; searching the data storage system through a processing device operatively coupled to the data storage system for processing requests for the talent files and the talent information; communicating requests for the talent files and the talent information through a user interface operatively coupled to the processing device, and communicating the talent files and talent information to a system user; selecting one or more talent files for possible booking of the corresponding performing artist; making an offer to book one or more of the performing artists for a performance having specified terms; and receiving a response to the offer from the performing artist. Upon agreement, the method further comprises consummating an electronic monetary transaction related to the offer between the system user and the performing artist.
摘要翻译： 提供一种预约人才的方法，包括：将多个人才档案存储在数据存储系统上，每个人才档案根据选择标准进行分类，并且其中每个人才档案包含与多个执行中的一个相关联的人才信息 艺术家 通过可操作地耦合到数据存储系统的处理设备来搜索数据存储系统，以处理对人才档案和人才信息的请求; 通过可操作地耦合到处理设备的用户界面来传送人才档案和人才信息的请求，并将人才档案和人才信息传送给系统用户; 选择一个或多个人才档案，以便可能预订相应的表演艺术家; 提出预定一名或多名表演艺术家参加具有指定条件的表演; 并收到来自表演艺术家的报价的回应。 一旦达成协议，该方法还包括完成与系统用户和表演艺术家之间的报价相关的电子货币交易。
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公开(公告)号：US20130338106A1
公开(公告)日：2013-12-19
申请号：US14000982
申请日：2012-02-23
申请人： John A. McCauley , Thomas J. Greshock , John Sanders , Heather H. Stevenson , Jonathan T. Kern , Ronald K. Chang
发明人： John A. McCauley , Thomas J. Greshock , John Sanders , Heather H. Stevenson , Jonathan T. Kern , Ronald K. Chang
IPC分类号： C07D409/14 , C07D417/14 , C07F7/10 , C07D409/04
CPC分类号： C07F7/10 , A61K31/38 , C07D333/72 , C07D409/04 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds of Formula I: and the pharmaceutically acceptable salts thereof, wherein “A” is S—; —SO—, —SO2—, —O— or NRa-, and Ra, and R1 through R5 are defined herein. Also disclosed are pharmaceutical formulations comprising a compound of Formula I and methods of treating, managing, or ameliorating diseases amenable to treatment, management, or amelioration by inhibition of LRRK2 kinase activity, for example, Parkinson's disease.
摘要翻译： 公开了式I的化合物及其药学上可接受的盐，其中“A”是S-; -SO - ， - SO 2 - ， - O-或NR a - ，且R a和R 1至R 5在本文中定义。 还公开了包含式I化合物的药物制剂以及通过抑制LRRK2激酶活性（例如帕金森病）治疗，治疗或改善易于治疗，治疗或改善的疾病的方法。
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公开(公告)号：US20060147624A1
公开(公告)日：2006-07-06
申请号：US11366697
申请日：2006-03-02
申请人： John Sanders , Grigory Mazo , Jacob Mazo
发明人： John Sanders , Grigory Mazo , Jacob Mazo
IPC分类号： B05D7/00
CPC分类号： C05G3/0029 , C05G3/0088 , C05G3/04 , C08F222/02 , C08F222/04 , C08F222/06 , C08F222/38 , Y10T428/2809
摘要： Biodegradable anionic polymers are disclosed which include recurring polymeric subunits preferably made up of dicarboxylic monomers such as maleic anhydride, itaconic anhydride or citraconic anhydride. Free radical polymerization is used in the synthesis of the polymers. The polymers may be complexed with ions and/or mixed with fertilizers or seeds to yield agriculturally useful compositions. The preferred products of the invention may be applied foliarly or to the earth adjacent growing plants in order to enhance nutrient uptake by the plants.
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5.发明申请QUIET VERTICAL TAKEOFF AND LANDING AIRCRAFT USING DUCTED, MAGNETIC INDUCTION AIR-IMPELLER ROTORS 失效使用导向，磁感应气动叶轮转子的垂直起落架和起落架公开(公告)号：US20060049304A1
公开(公告)日：2006-03-09
申请号：US10763973
申请日：2004-01-22
申请人： John Sanders , J. Sanders , Arturo Aviles , Arturo Aviles
发明人： John Sanders , J. Sanders , Arturo Aviles , Arturo Aviles
IPC分类号： B64C29/00
CPC分类号： B64C39/024 , B64C27/12 , B64C27/20 , B64C2201/027 , B64C2201/042 , B64C2201/108 , B64C2201/127
摘要： A hover aircraft employs an air impeller engine having an air channel duct and a rotor with outer ends of its blades fixed to an annular impeller disk that is driven by magnetic induction elements arrayed in the air channel duct. The air-impeller engine is arranged vertically in the aircraft frame to provide vertical thrust for vertical takeoff and landing. Preferably, the air-impeller engine employs dual, coaxial, contra-rotating rotors for increased thrust and gyroscopic stability. An air vane assembly directs a portion of the air thrust output at a desired angle to provide a horizontal thrust component for flight maneuvering or translation movement. The aircraft can employ a single engine in an annular fuselage, two engines on a longitudinal fuselage chassis, three engines in a triangular arrangement for forward flight stability, or other multiple engine arrangements in a symmetric, balanced configuration. Other flight control mechanisms may be employed, including side winglets, an overhead wing, and/or air rudders or flaps. An integrated flight control system can be used to operate the various flight control mechanisms. Electric power is supplied to the magnetic induction drives by high-capacity lightweight batteries or fuel cells. The hover aircraft is especially well suited for applications requiring VTOL deployment, hover operation for quiet surveillance, maneuvering in close air spaces, and long duration flights for continuous surveillance of ground targets and important facilities requiring constant monitoring.
摘要翻译： 悬停飞行器采用具有空气通道管道的空气叶轮发动机和其叶片的外端固定到环形叶轮盘的转子，其由排列在空气通道管道中的磁感应元件驱动。 空气叶轮发动机垂直布置在飞机框架中，以提供用于垂直起飞和着陆的垂直推力。 优选地，空气叶轮发动机采用双重同轴的反转转子，以提高推力和陀螺稳定性。 空气叶片组件将一部分空气推力输出引导到期望的角度，以提供用于飞行机动或平移运动的水平推力分量。 飞机可以在环形机身中使用单个发动机，在纵向机身底盘上使用两个发动机，三个发动机以三角形布置用于向前飞行稳定性，或以对称平衡配置的其它多个发动机装置。 可以采用其他飞行控制机构，包括侧翼，顶部翼和/或空气方向舵或翼。 集成的飞行控制系统可用于操作各种飞行控制机构。 电力通过大容量轻型电池或燃料电池供应给磁感应驱动器。 悬停式飞机特别适用于需要垂直起落架的部署，悬停操作，可进行安静的监视，在空中空间中进行机动操作，以及长时间飞行，以持续监视地面目标和需要持续监控的重要设施。
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6.发明申请公开(公告)号：US20050251057A1
公开(公告)日：2005-11-10
申请号：US10911112
申请日：2004-08-04
CPC分类号： A61B5/0452 , A61B5/4035 , G06Q50/24 , Y10S128/92
摘要： The invention concerns a method and apparatus for facilitating the provision of health care services using, for example, an application service provider. In one embodiment of the invention, a server computer, physiological testing unit and one or more computer program products coordinate with one another to perform the following tasks. First, receiving a request to utilize the physiological testing unit to process physiological data of a patient. Second, if the request is granted, enabling the physiological testing unit to process the physiological data of the patient. Third, if the request is granted, processing the account of a user.
摘要翻译： 本发明涉及一种使用例如应用服务提供商来促进提供医疗服务的方法和装置。 在本发明的一个实施例中，服务器计算机，生理测试单元和一个或多个计算机程序产品彼此协调以执行以下任务。 首先，接收利用生理测试单元处理患者生理数据的请求。 第二，如果请求被授权，使生理测试单元能够处理患者的生理数据。 第三，如果请求被授予，则处理用户的帐户。
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公开(公告)号：US09233977B2
公开(公告)日：2016-01-12
申请号：US13880992
申请日：2011-10-25
申请人： John A. McCauley , Hemaka A. Rajapakse , Thomas J. Greshock , John Sanders , Boyoung Kim , Vanessa L. Rada , Jonathan T. Kern , Heather H. Stevenson , Mark T. Bilodeau
发明人： John A. McCauley , Hemaka A. Rajapakse , Thomas J. Greshock , John Sanders , Boyoung Kim , Vanessa L. Rada , Jonathan T. Kern , Heather H. Stevenson , Mark T. Bilodeau
IPC分类号： C07D495/04 , C07D495/10 , A61K31/438 , A61K31/4365
CPC分类号： C07D495/04 , C07D495/10
摘要： Disclosed are compounds of Formula (I): and the pharmaceutically acceptable salts thereof, wherein “A” is S—; —SO—, —SO2—, —O— or NRac—, wherein Rac is H, or C1-20 alkyl and R1 through R5 are defined herein. Also disclosed are pharmaceutical formulations comprising a compound of Formula I and methods of treating, managing, or ameliorating diseases amenable to treatment, management, or amelioration by inhibition of LRRK2 kinase activity, for example, Parkinson's disease.
摘要翻译： 公开了式（I）的化合物及其药学上可接受的盐，其中“A”为S-; -SO - ， - SO 2 - ， - O-或NRac-，其中Rac是H，或C 1-20烷基和R 1至R 5在本文中定义。 还公开了包含式I化合物的药物制剂以及通过抑制LRRK2激酶活性（例如帕金森病）治疗，治疗或改善易于治疗，治疗或改善的疾病的方法。
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公开(公告)号：US20120095924A1
公开(公告)日：2012-04-19
申请号：US12959212
申请日：2010-12-02
申请人： John Sanders
发明人： John Sanders
CPC分类号： G06Q30/06 , G06Q20/10 , G06Q50/188
摘要： A method of booking talent is provided, comprising: storing a plurality of talent files on a data storage system, each of the talent files being categorized based on select criteria, and wherein each talent file contains talent information associated with one of a plurality of performing artists; searching the data storage system through a processing device operatively coupled to the data storage system for processing requests for the talent files and the talent information; communicating requests for the talent files and the talent information through a user interface operatively coupled to the processing device, and communicating the talent files and talent information to a system user; selecting one or more talent files for possible booking of the corresponding performing artist; making an offer to book one or more of the performing artists for a performance having specified terms; and receiving a response to the offer from the performing artist. Upon agreement, the method further comprises consummating an electronic monetary transaction related to the offer between the system user and the performing artist.
摘要翻译： 提供一种预约人才的方法，包括：将多个人才档案存储在数据存储系统上，每个人才档案根据选择标准进行分类，并且其中每个人才档案包含与多个执行中的一个相关联的人才信息 艺术家 通过可操作地耦合到数据存储系统的处理设备来搜索数据存储系统，以处理对人才档案和人才信息的请求; 通过可操作地耦合到处理设备的用户界面来传送人才档案和人才信息的请求，并将人才档案和人才信息传送给系统用户; 选择一个或多个人才档案，以便可能预订相应的表演艺术家; 提出预定一名或多名表演艺术家参加具有指定条件的表演; 并收到来自表演艺术家的报价的回应。 一旦达成协议，该方法还包括完成与系统用户和表演艺术家之间的报价相关的电子货币交易。
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公开(公告)号：US20070275931A1
公开(公告)日：2007-11-29
申请号：US11687570
申请日：2007-03-16
申请人： Eric Oldfield , Yongcheng Song , Yonghui Zhang , John Sanders
发明人： Eric Oldfield , Yongcheng Song , Yonghui Zhang , John Sanders
IPC分类号： A61K31/663 , A61P19/08 , C07C69/604 , C07C69/96 , C07D333/46 , C07D335/02 , C07F9/28
CPC分类号： C07F9/4037 , C07F9/3843 , C07F9/3856 , C07F9/3865 , C07F9/3869 , C07F9/3873 , C07F9/4028 , C07F9/404 , C07F9/4046 , C07F9/5414 , C07F9/5728 , C07F9/58 , C07F9/6506 , C07F9/655345 , C07F9/655363 , C07F9/72
摘要： The invention provides, inter alia, novel bisphosphonate compounds and methods of making and using. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor cell growth inhibition, activation of gammadelta T cells, inhibition of farnesyldiphosphate (FPPS) and/or undecaprenyldiphosphate synthase enzymes, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases. In regards to certain embodiments, a surprising advance has been the recognition that certain structural features can significantly enhance the activity of the compounds. For example, the presence of particular cationic species e.g., phosphonium, sulfonium, and arsonium moieties can contribute to desirable functional activity when positioned near a bisphosphonate moiety. In other embodiments of non-nitrogen containing bisphosphonates, terphenyl and benzyl bisphosphonate compounds and methods are provided. Further variations are also provided.
摘要翻译： 本发明尤其提供新的双膦酸盐化合物及其制备和使用方法。 在实施方案中，本发明提供了与研究和治疗应用相关的化合物和方法，例如用于肿瘤细胞生长抑制，Gammadelta T细胞的活化，法呢基二磷酸（FPPS）和/或十一烷基二磷酸合成酶的抑制，骨吸收疾病，癌症， 免疫疾病，免疫治疗和传染病。 关于某些实施方案，令人惊奇的进步是认识到某些结构特征可以显着增强化合物的活性。 例如，当位于二膦酸盐部分附近时，特定的阳离子物质例如鏻，锍和钍部分的存在可以有助于所需的功能活性。 在非含氮双膦酸盐的其它实施方案中，提供了三联苯基和苄基双膦酸盐化合物和方法。 还提供了进一步的变化。
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公开(公告)号：US20060150697A1
公开(公告)日：2006-07-13
申请号：US11363671
申请日：2006-02-28
申请人： John Sanders , Grigory Mazo , Jacob Mazo
发明人： John Sanders , Grigory Mazo , Jacob Mazo
IPC分类号： A01N25/00
CPC分类号： C05G3/0029 , C05G3/0088 , C05G3/04 , C08F222/02 , C08F222/04 , C08F222/06 , C08F222/38 , Y10T428/2809
摘要： Biodegradable anionic polymers are disclosed which include recurring polymeric subunits preferably made up of dicarboxylic monomers such as maleic anhydride, itaconic anhydride or citraconic anhydride. Free radical polymerization is used in the synthesis of the polymers. The polymers may be complexed with ions and/or mixed with fertilizers or seeds to yield agriculturally useful compositions. The preferred products of the invention may be applied foliarly or to the earth adjacent growing plants in order to enhance nutrient uptake by the plants.
摘要翻译： 公开了可生物降解的阴离子聚合物，其包括优选由二羧酸单体如马来酸酐，衣康酸酐或柠康酸酐组成的重复的聚合物亚单位。 自由基聚合用于聚合物的合成。 聚合物可以与离子络合和/或与肥料或种子混合以产生农业上有用的组合物。 本发明的优选产品可以叶面施用或邻近生长植物的土壤，以增强植物的营养吸收。
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