公开(公告)号：US20070269385A1

公开(公告)日：2007-11-22

申请号：US11748975

申请日：2007-05-15

申请人： Anthony Yun ,  Kirk Seward

发明人： Anthony Yun ,  Kirk Seward

IPC分类号： A61K31/7048 ,  A61K31/7034 ,  A61K39/395 ,  A61K31/496 ,  A61K31/366 ,  A61K31/22 ,  A61K31/65 ,  A61K31/33 ,  A61K9/12 ,  A61K31/34

CPC分类号： A61K31/22 ,  A61B17/24 ,  A61B17/3478 ,  A61K31/33 ,  A61K31/34 ,  A61K31/366 ,  A61K31/496 ,  A61K31/65 ,  A61K31/7034 ,  A61K31/7048 ,  A61M25/10 ,  A61M2025/105

摘要： Methods and kits for delivering pharmaceutical agents to the sinuses, sinus ostia, Eustachian tube, and pharynx are presented. A needle tip is translated through the mucosal tissue layer to a sub-epithelial or peri-luminal orientation and pharmaceutical agents are delivered into the sub-epithelial or peri-luminal tissue. Drugs distribute from the site of infusion to treat conditions including sinusitis and allergic rhinitis, among others.

摘要翻译： 提供用于将药剂递送到鼻窦，窦口，咽鼓管和咽部的方法和试剂盒。 针尖通过粘膜组织层翻译成亚上皮细胞或细胞周围取向，并将药剂递送至亚上皮细胞或管腔内组织。 药物从输注部位分配到治疗包括鼻窦炎和过敏性鼻炎等病症。

公开(公告)号：US20060035974A1

公开(公告)日：2006-02-16

申请号：US11198003

申请日：2005-08-05

申请人： Anthony Yun ,  Patrick Lee ,  Albert Cha

发明人： Anthony Yun ,  Patrick Lee ,  Albert Cha

IPC分类号： A61K31/202

CPC分类号： A61K31/202

摘要： The present invention is directed to a methods and compositions for enhancing the probability that a subject will become pregnant. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a linoleic acid active agent, e.g., linoleic acid, a polyunsaturated fatty acid analog thereof, etc. Also provided are kits that find use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications, including but not limited to the treatment of infertility conditions.

摘要翻译： 本发明涉及增加受试者将怀孕的可能性的方法和组合物。 该方法包括向受试者施用包含有效量的亚油酸活性剂，例如亚油酸，其多不饱和脂肪酸类似物等的药物组合物。还提供了用于实践本发明方法的试剂盒。 本发明的方法和组合物可用于各种不同的应用，包括但不限于不育症状的治疗。

公开(公告)号：US20050256028A1

公开(公告)日：2005-11-17

申请号：US10846486

申请日：2004-05-13

申请人： Anthony Yun ,  Patrick Lee

发明人： Anthony Yun ,  Patrick Lee

IPC分类号： A61K31/137 ,  A61K31/4745 ,  A61K31/57 ,  A61K38/08 ,  A61K38/11 ,  A61K38/22 ,  A61K38/26 ,  A61K38/48

CPC分类号： A61K31/137 ,  A61K31/4745 ,  A61K31/57 ,  A61K38/085 ,  A61K38/11 ,  A61K38/2221 ,  A61K38/26 ,  A61K38/4813

摘要： Methods are provided for treating a subject for a condition. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated during at least one predetermined phase of the subject's menstrual cycle to alter the parasympathetic activity/sympathetic activity ratio in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, including various disease conditions, that increase in severity and/or occurrence during one or more phases of the menstrual cycle. Also provided are systems and kits for use in practicing the subject methods.

摘要翻译： 提供用于治疗受试者的病症的方法。 根据本发明的方法，受试者的自主神经系统的至少一部分在受试者的月经周期的至少一个预定阶段被调节，以以有效治疗受试者的方式改变副交感神经活动/交感活动比 条件。 主题方法用于治疗各种不同的病症，包括各种疾病状况，其在月经周期的一个或多个阶段中严重性和/或发生率增加。 还提供了用于实践主题方法的系统和工具包。

公开(公告)号：US20050153885A1

公开(公告)日：2005-07-14

申请号：US10962190

申请日：2004-10-07

申请人： Anthony Yun ,  Patrick Lee

发明人： Anthony Yun ,  Patrick Lee

IPC分类号： A61K31/00 ,  A61K38/24 ,  A61K31/137 ,  A61K31/138 ,  A61K31/401 ,  A61K31/455 ,  A61K31/46 ,  A61K31/57 ,  A61K31/58 ,  A61K38/04

CPC分类号： A61K31/00

摘要： Methods are provided for treating a subject for a condition caused by an abnormality in the subject's autonomic nervous system. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is pharmacologically modulated with at least one aldosterone antagonist in a manner that is effective to treat the subject for the condition. Also provided are systems and kits for use in practicing the subject methods.

摘要翻译： 提供用于治疗受试者由于受试者的自主神经系统异常引起的病症的方法。 根据本发明的方法，受试者的自主神经系统的至少一部分以至少一种醛固酮拮抗剂以有效治疗该病人的方式进行药理学调节。 还提供了用于实践主题方法的系统和工具包。

公开(公告)号：US20050021092A1

公开(公告)日：2005-01-27

申请号：US10871366

申请日：2004-06-18

申请人： Anthony Yun ,  Patrick Lee

发明人： Anthony Yun ,  Patrick Lee

IPC分类号： A61N1/32 ,  A61N1/34 ,  A61N1/36 ,  A61N1/18

CPC分类号： A61N1/36017 ,  A61N1/326 ,  A61N1/36014 ,  A61N1/36021 ,  A61N1/36071 ,  A61N1/36189

摘要： Methods are provided for treating a subject for a condition caused by an abnormality in the subject's autonomic nervous system. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated to increase the parasympathetic activity/sympathetic activity ratio in a manner that is effective to treat the subject for the condition. Certain embodiments include modulating at least a portion of a subject's autonomic nervous system by inhibiting and/or increasing activity in at least a portion of the subject's autonomic nervous system. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.

摘要翻译： 提供用于治疗受试者由于受试者的自主神经系统异常引起的病症的方法。 根据本发明的方法，调节受试者的自主神经系统的至少一部分以增加副交感神经活动/交感活动比，以有效治疗受试者的状况。 某些实施方案包括通过抑制和/或增加受试者的自主神经系统的至少一部分中的活性来调节受试者的自主神经系统的至少一部分。 主题方法用于治疗各种不同的病症，其中这些病症包括各种疾病状况。 还提供了用于实践主题方法的系统和工具包。

公开(公告)号：US20070112327A1

公开(公告)日：2007-05-17

申请号：US11592027

申请日：2006-11-01

申请人： Anthony Yun ,  Patrick Lee

发明人： Anthony Yun ,  Patrick Lee

IPC分类号： A61M31/00 ,  A61K9/22

CPC分类号： A61K9/0034 ,  A61N1/36007

摘要： Methods for treating a renal associated disease condition in a subject are provided. The subject methods are characterized by modulating at least one portion of the subject's autonomic nervous system in a manner effective to treat a renal condition in the subject. Specifically, the methods may include modulating, e.g., increasing, a parasympathetic/sympathetic activity ratio in the subject. Also provided are compositions, kits and systems for practicing the subject methods.

摘要翻译： 提供了治疗受试者的肾脏相关疾病状况的方法。 本发明方法的特征在于以有效治疗受试者的肾脏状况的方式调节受试者的自主神经系统的至少一部分。 具体地，所述方法可以包括调节，例如增加受试者的副交感神经/交感活动比。 还提供了用于实践本发明方法的组合物，试剂盒和系统。

公开(公告)号：US20060206149A1

公开(公告)日：2006-09-14

申请号：US11343940

申请日：2006-01-30

申请人： Anthony Yun

发明人： Anthony Yun

IPC分类号： A61N1/00

CPC分类号： A61N1/326 ,  A61N2/002

摘要： Methods for treating a disease condition in a subject are provided. The subject methods include selectively modulating at least one biological activity of advential tissue in a manner effective to treat the disease condition. Also provided are compositions, kits and systems for use in practicing the subject methods.

摘要翻译： 提供了治疗受试者的疾病状况的方法。 主题方法包括以有效治疗疾病状况的方式选择性调节外膜组织的至少一种生物活性。 还提供了用于实践本发明方法的组合物，试剂盒和系统。

公开(公告)号：US20060069012A1

公开(公告)日：2006-03-30

申请号：US11238108

申请日：2005-09-27

申请人： Anthony Yun ,  Patrick Lee

发明人： Anthony Yun ,  Patrick Lee

IPC分类号： A61K38/22 ,  A61K38/09 ,  A61K38/24

CPC分类号： A61K31/00 ,  A61K31/4045 ,  A61K41/0004 ,  A61K45/06 ,  A61N1/326 ,  A61N1/36082 ,  A61N1/36103

摘要： Methods and compositions for at least maintaining plasticity in a system of a subject are provided. Embodiments of the subject methods include lowering long term potentiation in said subject in a manner effective to at least maintain plasticity of a system in said subject.

摘要翻译： 提供了用于至少维持受试者系统中的可塑性的方法和组合物。 本发明方法的实施方案包括以有效至少维持所述受试者系统的可塑性的方式降低所述受试者的长期增强作用。

公开(公告)号：US20060200194A1

公开(公告)日：2006-09-07

申请号：US11318336

申请日：2005-12-23

申请人： Anthony Yun

发明人： Anthony Yun

IPC分类号： A61B17/00

CPC分类号： A61B17/12013

摘要： A harness for treating vessel aneurysms is disclosed. The harness applies elastic, compressive reinforcement on the aneurysm to reduce deleterious wall tension and to resist the shape change of the vessel. Rather than imposing a dimension beyond which the aneurysm cannot expand, the harness provides no hard limit over the range of systolic expansion of the vessel. Instead, the harness follows the contour of the vessel throughout systole and continuously exerts gentle resistance to stretch. Also disclosed is a method of delivering the vessel harness to the vessel with minimal invasion.

公开(公告)号：US20060190052A1

公开(公告)日：2006-08-24

申请号：US11344586

申请日：2006-01-30

申请人： Anthony Yun ,  Patrick Lee

发明人： Anthony Yun ,  Patrick Lee

IPC分类号： A61N1/18

CPC分类号： A61N1/3601

摘要： Methods and compositions for treating a subject for obesity-hypoventilation syndrome, or related conditions, are provided. The subject methods include applying an electrical stimulus to a subject in a manner that modulates chest cavity capacity in a manner effective to treat the subject. Also provided are compositions, kits and systems for use in practicing the subject methods.

摘要翻译： 提供了用于治疗受试者的肥胖 - 通气不足综合征或相关病症的方法和组合物。 主题方法包括以以有效治疗受试者的方式调节胸腔容量的方式对受试者施加电刺激。 还提供了用于实践本发明方法的组合物，试剂盒和系统。