公开(公告)号：US07232833B2

公开(公告)日：2007-06-19

申请号：US10810711

申请日：2004-03-26

申请人： Antony Bigot ,  Youssef El-Ahmad ,  Jean-Luc Malleron ,  Jean-Paul Martin ,  Serge Mignani ,  Guy Pantel ,  Baptiste Ronan ,  Michel Tabart ,  Michel Cheve ,  Fabrice Viviani

发明人： Antony Bigot ,  Youssef El-Ahmad ,  Jean-Luc Malleron ,  Jean-Paul Martin ,  Serge Mignani ,  Guy Pantel ,  Baptiste Ronan ,  Michel Tabart ,  Michel Cheve ,  Fabrice Viviani

IPC分类号： A61K31/47 ,  A61K31/517 ,  A61K31/44 ,  A61K31/50 ,  A61K31/54

CPC分类号： C07D401/06 ,  C07D409/14 ,  C07D413/06

摘要： The invention relates to 4-substituted quinoline compounds of general formula: which are active as antimicrobials, in which: X1, X2, X3, X4 and X5 is C—R′1, to C—R′5 respectively, or alternatively at most one represents N, Y represents CHR, CO, CROH, CRNH2, CRF or CF2, R being a hydrogen or alkyl, m is 1, 2 or 3 and n is 0, 1 or 2, Z is CH2 or Z is O, S, SO, SO2 and, in this case, n is equal to 2, R2 is —CO2R, —CH2CO2R, —CH2—CH2CO2R, —CH2OH or —CH2—CH2OH, wherein R is as defined above, R3 represents phenyl, heteroaryl or alk-Ro3, where alk is alkyl and Ro3 represents various groups, where appropriate containing oxygen, sulfur or amine, in their enantiomeric or diastereoisomeric forms or their mixtures, and/or where appropriate in the syn or anti form or their mixtures, and their salts.

摘要翻译： 本发明涉及以下通式的4-取代喹啉化合物：其作为抗微生物剂是有活性的，其中：X 1，X 2，X 3， >，X 4和X 5分别为C-R'1，C-R'5， 或者至多一个表示N，Y表示CHR，CO，CROH，CRNH 2，CRF或CF 2，R为氢或烷基，m为1,2 或3，n为0,1或2，Z为CH 2或Z为O，S，SO，SO 2，在这种情况下，n等于 2，R 2是-CO 2 R，-CH 2 CO 2 R，-CH 2， 2个-CH 2 CO 2 R 2，-CH 2 OH或-CH 2 -CH（CH 2） R 2 OH，其中R如上所定义，R 3表示苯基，杂芳基或烷基-SO 3 - ， - 其中烷基是烷基，R 3 O 3表示各种基团，其中适当地含有它们的对映体或非对映异构形式或其混合物中的氧，硫或胺， d /或适当时以合成或反式形式或其混合物及其盐。

公开(公告)号：US6124465A

公开(公告)日：2000-09-26

申请号：US346540

申请日：1999-07-02

申请人： Jean-Dominique Bourzat ,  Alain Commer.cedilla.on ,  Norbert Dereu ,  Patrick Mailliet ,  Fabienne Sounigo-Thompson ,  Jean-Paul Martin ,  Marc Capet ,  Michel Cheve

发明人： Jean-Dominique Bourzat ,  Alain Commer.cedilla.on ,  Norbert Dereu ,  Patrick Mailliet ,  Fabienne Sounigo-Thompson ,  Jean-Paul Martin ,  Marc Capet ,  Michel Cheve

IPC分类号： C07D209/56 ,  C07D233/56 ,  C07D401/08 ,  C07D209/80 ,  C07F9/28

CPC分类号： C07D209/56

摘要： Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl radical or a polycyclic or heterocyclic aromatic radical, R represents a radical of general formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z in which X.sub.1 =single bond, O, S; m=0, 1; n=0, 1, 2; it being possible for the CH.sub.2 radicals to be substituted; Z represents carboxyl, COOR.sub.6 (R.sub.6 =alkyl), CON(R.sub.7)(R.sub.8) (R.sub.7 =hydrogen or alkyl and R.sub.8 =hydrogen, hydroxyl, arylsulphonyl, heterocyclyl, optionally substituted amino, optionally substituted alkyloxy or optionally substituted alkyl), PO(OR.sub.9).sub.2 (R.sub.9 =hydrogen or alkyl), an --NH--CO--T (T=hydrogen or optionally substituted alkyl) radical, or else--a ##STR2## radical, R.sub.1 and R.sub.2 =hydrogen or halogen or alkyl, alkyloxy, which is optionally substituted, alkylthio, alkyloxycarbonyl or else R.sub.1 and R.sub.2, at the ortho position with respect to one another, form an optionally substituted heterocycle containing 1 or 2 heteroatoms, R.sub.3 and R.sub.4 =hydrogen or halogen or alkyl, alkenyl, alkyloxy, alkylthio. carboxyl or alkyloxycarbonyl, R.sub.5 =hydrogen, alkyl, alkylthio, X=O or S or --NH--, --CO--, methylene, vinyldiyl, alkene-1,1-diyl or cycloalkane-1,1-diyl, and Y=O or S, in the racemic form, as well as the optical isomers (diastereomers and enantiomers) and the salts of the product of formula (I). The compounds of formula (I) are farnesyl transferase inhibitors which exhibit notable antitumor and antileukemic properties.

摘要翻译： 式（I）的新产品，其制备方法，含有它们的药物组合物及其在制备药物中的用途。 在式（I）中，以下取代基是优选的：Ar表示取代或稠合的苯基或多环或杂环芳族基，R表示通式 - （CH 2）m -X1（CH 2）n Z 其中X1 =单键，O，S; m = 0,1， n = 0,1,2; CH2基可以被取代; Z代表羧基，COOR6（R6 =烷基），CON（R7）（R8）（R7 =氢或烷基，R8 =氢，羟基，芳基磺酰基，杂环基，任选取代的氨基，任选取代的烷氧基或任选取代的烷基），PO OR 9）2（R 9 =氢或烷基），-NH-CO-T（T =氢或任选取代的烷基）基团，或者 - 基团，R 1和R 2 =氢或卤素或烷基，烷氧基， 取代的烷硫基，烷氧基羰基，或者R1和R2相对于彼此的邻位，形成含有1或2个杂原子的任选取代的杂环，R 3和R 4 =氢或卤素或烷基，烯基，烷氧基，烷硫基。 羧基或烷氧基羰基，R5 =氢，烷基，烷硫基，X = O或S或-NH-，-CO-，亚甲基，乙烯基二烯基，烯-1,1-二基或环烷烃-1,1-二基，Y = O 或S，外消旋形式，以及光学异构体（非对映体和对映体）和式（I）的产物的盐。 式（I）化合物是具有显着的抗肿瘤和抗白血病性质的法呢基转移酶抑制剂。

公开(公告)号：US6013662A

公开(公告)日：2000-01-11

申请号：US999408

申请日：1997-12-29

申请人： Jean-Dominique Bourzat ,  Alain Commer.cedilla.on ,  Norbert Dereu ,  Patrick Mailliet ,  Fabienne Sounigo-Thompson ,  Jean-Paul Martin ,  Marc Capet ,  Michel Cheve

发明人： Jean-Dominique Bourzat ,  Alain Commer.cedilla.on ,  Norbert Dereu ,  Patrick Mailliet ,  Fabienne Sounigo-Thompson ,  Jean-Paul Martin ,  Marc Capet ,  Michel Cheve

IPC分类号： C07D209/56 ,  C07D209/72 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  A01N43/38 ,  C07D235/08 ,  C07D401/08

CPC分类号： C07D401/12 ,  C07D209/56 ,  C07D209/72 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14

摘要： Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl radical or a polycyclic or heterocyclic aromatic radical, R represents a radical of general formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z in which X.sub.1 =single bond, O, S; m=0, 1; n=0, 1, 2; it being possible for the CH.sub.2 radicals to be substituted; Z represents carboxyl, COOR.sub.6 (R.sub.6 =alkyl), CON(R.sub.7)(R.sub.8) (R.sub.7 =hydrogen or alkyl and R.sub.8 =hydrogen, hydroxyl, arylsulphonyl, heterocyclyl, optionally substituted amino, optionally substituted alkyloxy or optionally substituted alkyl), PO(OR.sub.9).sub.2 (R.sub.9 =hydrogen or alkyl), an --NH--CO--T (T=hydrogen or optionally substituted alkyl) radical, or elsea ##STR2## radical, R.sub.1 and R.sub.2 =hydrogen or halogen or alkyl, alkyloxy which is optionally substituted, alkylthio, alkyloxycarbonyl or else R.sub.1 and R.sub.2, at the ortho position with respect to one another, form an optionally substituted heterocycle containing 1 or 2 heteroatoms, R.sub.3 and R.sub.4 =hydrogen or halogen or alkyl, alkenyl, alkyloxy, alkylthio, carboxyl or alkyloxycarbonyl, R.sub.5 =hydrogen, alkyl, alkylthio, X=O or S or --NH--, --CO--, methylene, vinyldiyl, alkene-1,1-diyl or cycloalkane-1,1-diyl, and Y=O or S, in the racemic form, as well as the optical isomers (diastereomers and enantiomers) and the salts of the product of formula (I). The compounds of formula (I) are farnesyl transferase inhibitors which exhibit notable antitumor and antileukemic properties.

摘要翻译： 式（I）的新产品，其制备方法，含有它们的药物组合物及其在制备药物中的用途。 在式（I）中，以下取代基是优选的：Ar表示取代或稠合的苯基或多环或杂环芳族基，R表示通式 - （CH 2）m -X1（CH 2）n Z 其中X1 =单键，O，S; m = 0,1， n = 0,1,2; CH2基可以被取代; Z代表羧基，COOR6（R6 =烷基），CON（R7）（R8）（R7 =氢或烷基，R8 =氢，羟基，芳基磺酰基，杂环基，任选取代的氨基，任选取代的烷氧基或任选取代的烷基），PO OR 9）2（R 9 =氢或烷基），-NH-CO-T（T =氢或任选取代的烷基）基团，或者基团，R 1和R 2 =氢或卤素或任选被取代的烷基， 烷基硫代，烷氧基羰基，或者R1和R2相对于彼此的邻位，形成任选取代的含有1或2个杂原子的杂环，R 3和R 4 =氢或卤素或烷基，烯基，烷氧基，烷硫基，羧基或烷氧基羰基， R5 =氢，烷基，烷硫基，X = O或S或-NH-，-CO-，亚甲基，乙烯基二烯基，烯-1,1-二基或环烷烃-1,1-二基，Y = O或S 外消旋形式，以及光学异构体（非对映异构体和对映体）和式（I）的产物的盐。 式（I）化合物是具有显着的抗肿瘤和抗白血病性质的法呢基转移酶抑制剂。

公开(公告)号：US06218406B1

公开(公告)日：2001-04-17

申请号：US09346303

申请日：1999-07-02

申请人： Jean-Dominique Bourzat ,  Alain Commerçon ,  Norbert Dereu ,  Patrick Mailliet ,  Fabienne Sounigo-Thompson ,  Jean-Paul Martin ,  Marc Capet ,  Michel Cheve

发明人： Jean-Dominique Bourzat ,  Alain Commerçon ,  Norbert Dereu ,  Patrick Mailliet ,  Fabienne Sounigo-Thompson ,  Jean-Paul Martin ,  Marc Capet ,  Michel Cheve

IPC分类号： A61K314439

CPC分类号： C07D401/12 ,  C07D209/56 ,  C07D209/72 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14

摘要： Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl radical or a polycyclic or heterocyclic aromatic radical, R represents a radical of general formula —(CH2)m—X1—(CH2)n—Z in which X1=single bond, O, S; m=0, 1; n=0, 1, 2; it being possible for the CH2 radicals to be substituted; Z represents carboxyl, COOR6 (R6=alkyl), CON(R7)(R8) (R7=hydrogen or alkyl and R8=hydrogen, hydroxyl, arylsulphonyl, heterocyclyl, optionally substituted amino, optionally substituted alkyloxy or optionally substituted alkyl), PO(OR9)2 (R9=hydrogen or alkyl), an —NH—CO—T (T=hydrogen or optionally substituted alkyl) radical, or else—a radical, R1 and R2=hydrogen or halogen or alkyl, alkyloxy, which is optionally substituted, alkylthio, alkyloxycarbonyl or else R1 and R2, at the ortho position with respect to one another, form an optionally substituted heterocycle containing 1 or 2 heteroatoms, R3 and R4=hydrogen or halogen or alkyl, alkenyl, alkyloxy, alkylthio, carboxyl or alkyloxycarbonyl, R5=hydrogen, alkyl, alkylthio, X=O or S or —NH—, —CO—, methylene, vinyldiyl, alkene-1,1-diyl or cycloalkane-1,1-diyl, and Y=O or S, in the racemic form, as well as the optical isomers (diastereomers and enantiomers) and the salts of the product of formula (I). The compounds of formula (I) are farnesyl transferase inhibitors which exhibit notable antitumor and antileukemic properties.

摘要翻译： 式（I）的新型产物，其制备方法，含有它们的药物组合物及其在制备药物中的用途。在式（I）中，以下取代基是优选的：Ar表示取代或缩合的苯基或 多环或杂环芳族基团，R表示通式为（CH 2）m -X1（CH 2）n Z的基团，其中X1 =单键，O，S; m = 0,1， n = 0,1,2; CH2基可以被取代; Z代表羧基，COOR6（R6 =烷基），CON（R7）（R8）（R7 =氢或烷基，R8 =氢，羟基，芳基磺酰基，杂环基，任选取代的氨基，任选取代的烷氧基或任选取代的烷基），PO OR 9）2（R 9 =氢或烷基），-NH-CO-T（T =氢或任选取代的烷基）基团，或不相关的，R 1和R 2 =氢或卤素或烷基，烷氧基，其被任选取代 ，烷硫基，烷氧基羰基或其它R1和R2在相邻的邻位形成含有1或2个杂原子的任选取代的杂环，R 3和R 4 =氢或卤素或烷基，烯基，烷氧基，烷硫基，羧基或烷氧基羰基 ，R5 =氢，烷基，烷硫基，X = O或S或-NH-，-CO-，亚甲基，乙烯基二烯基，烯-1,1-二基或环烷烃-1,1-二基，Y = O或S， 外消旋形式，以及光学异构体（非对映异构体和对映体）和式（I）的产物的盐。 式（I）化合物是具有显着的抗肿瘤和抗白血病性质的法呢基转移酶抑制剂。

公开(公告)号：US07230007B2

公开(公告)日：2007-06-12

申请号：US10865454

申请日：2004-06-10

申请人： Jean-Christophe Carry ,  Gilles Doerflinger ,  Arielle Genevois-Borella ,  Michel Evers ,  Alain Le Brun ,  Jean-Paul Martin ,  Pascal Desmazeau ,  Serge Mignani ,  Heinz-Werner Kleemann

发明人： Jean-Christophe Carry ,  Gilles Doerflinger ,  Arielle Genevois-Borella ,  Michel Evers ,  Alain Le Brun ,  Jean-Paul Martin ,  Pascal Desmazeau ,  Serge Mignani ,  Heinz-Werner Kleemann

IPC分类号： A61K31/44 ,  C07D471/02

CPC分类号： C07D471/04

摘要： The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.

摘要翻译： 本发明公开并要求式I化合物及其药学上可接受的盐，以及使用所述式I化合物单独或与其它药物组合的抗心律失常药物与预防或治疗梗死的心脏保护组分的方法，用于 心绞痛的治疗以及与局部缺血诱导的损伤发展相关的病理生理过程的抑制剂，特别是引发缺血诱导的心律失常和心力衰竭。 包含式I化合物或式I化合物与一种或多种其它药物组合的药物组合物和式I化合物的制备方法也被公开并要求保护。

公开(公告)号：US20050014758A1

公开(公告)日：2005-01-20

申请号：US10865454

申请日：2004-06-10

申请人： Jean-Christophe Carry ,  Gilles Doerflinger ,  Arielle Genevois-Borella ,  Michel Evers ,  Alain Le Brun ,  Jean-Paul Martin ,  Pascal Desmazeau ,  Serge Mignani ,  Heinz-Werner Kleemann

发明人： Jean-Christophe Carry ,  Gilles Doerflinger ,  Arielle Genevois-Borella ,  Michel Evers ,  Alain Le Brun ,  Jean-Paul Martin ,  Pascal Desmazeau ,  Serge Mignani ,  Heinz-Werner Kleemann

IPC分类号： C07D471/04 ,  C07D471/02 ,  A61K31/4745 ,  A61K31/503 ,  A61K31/519 ,  C07D487/02

CPC分类号： C07D471/04

摘要： The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.

摘要翻译： 本发明公开并要求式I化合物及其药学上可接受的盐，以及使用所述式I化合物单独或与其它药物组合的抗心律失常药物与预防或治疗梗死的心脏保护组分的方法，用于 心绞痛的治疗以及与局部缺血诱导的损伤发展相关的病理生理过程的抑制剂，特别是引发缺血诱导的心律失常和心力衰竭。 包含式I化合物或式I化合物与一种或多种其它药物组合的药物组合物和式I化合物的制备方法也被公开并要求保护。

公开(公告)号：US08675066B2

公开(公告)日：2014-03-18

申请号：US12893162

申请日：2010-09-29

申请人： Stephen Scott Trundle ,  Robert J. McCarthy, Jr. ,  Jean-Paul Martin ,  Alison Jane Slavin ,  David James Hutz

发明人： Stephen Scott Trundle ,  Robert J. McCarthy, Jr. ,  Jean-Paul Martin ,  Alison Jane Slavin ,  David James Hutz

IPC分类号： H04N7/18

CPC分类号： G08B13/19639 ,  G08B13/196 ,  G08B13/19613 ,  G08B13/19634 ,  G08B13/1966 ,  G08B25/008 ,  G08B25/14 ,  G08B29/046 ,  H04N7/183 ,  H04N7/188

摘要： Image surveillance and reporting technology, in which an event that is indicative of potential physical activity within an area corresponding to a location of a camera unit is detected. In response to detection of the event, the camera unit is controlled to capture one or more images of the area corresponding to the location of the camera unit. The one or more images captured by the camera unit are analyzed to determine whether the one or more images include image data that is indicative of relevant physical activity within the area corresponding to the location of the camera unit. The one or more images are handled based on the determination of whether the one or more images include image data that is indicative of relevant physical activity within the area corresponding to the location of the camera unit.

摘要翻译： 检测图像监视和报告技术，其中检测到指示与相机单元的位置相对应的区域内潜在的身体活动的事件。 响应于事件的检测，控制相机单元以捕获与相机单元的位置相对应的区域的一个或多个图像。 分析由相机单元捕获的一个或多个图像，以确定一个或多个图像是否包括指示与相机单元的位置相对应的区域内的相关身体活动的图像数据。 基于确定一个或多个图像是否包括指示在与相机单元的位置相对应的区域内的相关身体活动的图像数据来处理一个或多个图像。

公开(公告)号：US08531294B2

公开(公告)日：2013-09-10

申请号：US12782668

申请日：2010-05-18

申请人： Alison Jane Slavin ,  Jean-Paul Martin ,  Daniel Ramos

发明人： Alison Jane Slavin ,  Jean-Paul Martin ,  Daniel Ramos

IPC分类号： G08B13/00

CPC分类号： G08B13/2462 ,  G08B13/2402 ,  G08B13/2491 ,  G08B21/18 ,  G08B25/008 ,  G08B25/14

摘要： Techniques are described for moving asset location tracking and monitoring system technology. A system monitors for events related to a monitoring system that monitors a fixed property and the system detects an event related to the monitoring system based on the monitoring. The system performs an operation that leverages geographic location tracking of at least one mobile asset associated with the fixed property based on the detected event.

摘要翻译： 描述了移动资产定位跟踪和监控系统技术的技术。 系统监视与监控系统相关的事件，监控系统监控固定属性，系统会根据监控情况检测与监控系统有关的事件。 该系统基于检测到的事件执行利用与固定属性相关联的至少一个移动资产的地理位置跟踪的操作。

公开(公告)号：US08493202B1

公开(公告)日：2013-07-23

申请号：US13053994

申请日：2011-03-22

申请人： Stephen Scott Trundle ,  Alison Jane Slavin ,  Jean-Paul Martin

发明人： Stephen Scott Trundle ,  Alison Jane Slavin ,  Jean-Paul Martin

IPC分类号： G08B23/00

CPC分类号： G08B29/046 ,  G08B25/005 ,  G08B25/006 ,  G08B25/008 ,  G08B29/02 ,  G08B29/185

摘要： Techniques are described for handling an event where a control panel or an alarm signaling device is tampered with or destroyed by a disablement tactic, e.g., a “crash and smash intrusion.”

摘要翻译： 描述了用于处理事件的技术，其中控制面板或警报信号装置被诸如“崩溃和粉碎入侵”的禁用策略篡改或破坏。

公开(公告)号：US08467763B2

公开(公告)日：2013-06-18

申请号：US13403082

申请日：2012-02-23

申请人： Jean-Paul Martin ,  Stephen Scott Trundle ,  David Saul Goldfarb ,  David James Hutz

发明人： Jean-Paul Martin ,  Stephen Scott Trundle ,  David Saul Goldfarb ,  David James Hutz

IPC分类号： H04M11/04

CPC分类号： G08B25/14 ,  G08B13/00 ,  G08B25/08 ,  G08B25/10 ,  H04M11/04 ,  H04W4/90

摘要： Techniques are described for establishing a two-way voice communication session with an alarm system. The alarm system may establish a two-way voice communication session with an operator associated with a monitoring service that provides monitoring services for alarm events detected by the alarm system. The alarm system also may establish a two-way voice communication session with a notification recipient that is interested in receiving notifications associated with events detected by the alarm system.

摘要翻译： 描述了用于与报警系统建立双向语音通信会话的技术。 报警系统可以与与监控服务相关联的运营商建立双向语音通信会话，监控服务为报警系统检测到的报警事件提供监控服务。 报警系统还可以与有兴趣接收与由报警系统检测到的事件有关的通知的通知接收者建立双向语音通信会话。