专利检索 ap:("Aranapakam Mudumbai Venkatesan" OR "Tarek Suhayl Mansour" OR "Takao Abe" OR "Itsuki Yamamura" OR "Tsuyoshi Takasaki" OR "Atul Agarwal" OR "Osvaldo Dos Santos" OR "Fuk-Wah Sum" OR "Yang-I Lin") AND inv:"Aranapakam Mudumbai Venkatesan" 第 1 页

1.

发明授权
Bicyclic 6-alkylidene-penems as β-lactamase inhibitors 失效
标题翻译：双环6-亚烷基 - 青霉烯作为β-内酰胺酶抑制剂

公开(公告)号：US07112582B2

公开(公告)日：2006-09-26

申请号：US10427380

申请日：2003-05-01

申请人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Itsuki Yamamura , Tsuyoshi Takasaki , Atul Agarwal , Osvaldo dos Santos , Fuk-Wah Sum , Yang-I Lin

发明人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Itsuki Yamamura , Tsuyoshi Takasaki , Atul Agarwal , Osvaldo dos Santos , Fuk-Wah Sum , Yang-I Lin

IPC分类号： C07D499/881 , C07D519/06 , C07D513/04 , A61K31/431 , A61P31/04

CPC分类号： C07D519/00 , C07D499/861 , C07D499/88 , C07D503/00

摘要： The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X is S.

摘要翻译： 本发明提供式I化合物，药物组合物及其在有需要的患者中治疗细菌感染或疾病的用途。其中A和B之一表示氢，另一个表示任选取代的稠合双环杂芳基; 而X是S.

2.

发明申请
Bicyclic 6-Alkylidene-Penems as Beta-Lactamase Inhibitors 失效
标题翻译：双环6-亚烷基 - 半乳糖苷作为β-内酰胺酶抑制剂

公开(公告)号：US20080312203A1

公开(公告)日：2008-12-18

申请号：US12195706

申请日：2008-08-21

申请人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Itsuki Yamamura , Tsuyoshi Takasaki , Atul Agarwal , Osvaldo Dos Santos , Fuk-Wah Sum , Yang-I Lin

发明人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Itsuki Yamamura , Tsuyoshi Takasaki , Atul Agarwal , Osvaldo Dos Santos , Fuk-Wah Sum , Yang-I Lin

IPC分类号： A61K31/424 , C07D503/10 , A61K31/431 , A61K31/546 , A61K31/5365 , C07D498/04 , A61K31/545 , A61K31/43 , A61P31/04

CPC分类号： C07D519/00 , C07D499/861 , C07D499/88 , C07D503/00

摘要： The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X is O, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.

摘要翻译： 本发明提供式Ⅰ化合物，其中A和B之一为氢，另一个为任选取代的稠合双环杂芳基; X是O，药物组合物及其在有需要的患者中治疗细菌感染或疾病的用途。

3.

发明授权
Bicyclic 6-alkylidene-penems as β-lactamase inhibitors 失效
标题翻译：双环6-亚烷基 - 半乳糖和β-内酰胺酶抑制剂

公开(公告)号：US07812014B2

公开(公告)日：2010-10-12

申请号：US12195706

申请日：2008-08-21

申请人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Itsuki Yamamura , Tsuyoshi Takasaki , Atul Agarwal , Osvaldo Dos Santos , Fuk-Wah Sum , Yang-I Lin

发明人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Itsuki Yamamura , Tsuyoshi Takasaki , Atul Agarwal , Osvaldo Dos Santos , Fuk-Wah Sum , Yang-I Lin

IPC分类号： C07D519/06 , C07D513/04 , A61P31/04 , A61K31/424 , C07D499/881 , A61K31/431

CPC分类号： C07D519/00 , C07D499/861 , C07D499/88 , C07D503/00

摘要： The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group as defined herein; X is O; R5 is H, C1-C6 alkyl, C5-C6 cycloalkyl, or CHR3OCOC1-C6 alkyl; and R3 is hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.

摘要翻译： 本发明提供式I化合物，其中A和B之一是氢，另一个如本文定义的任选取代的稠合双环杂芳基; X是O; R5是H，C1-C6烷基，C5-C6环烷基或CHR3OCOC1-C6烷基; 和R 3是氢，C 1 -C 6烷基，C 5 -C 6环烷基，任选取代的芳基或任选取代的杂芳基; 或其药学上可接受的盐; 和药物组合物及其在有需要的患者中治疗细菌感染或疾病的用途。

4.

发明授权
Tricyclic 6-alkylidene-penems as β-lactamase inhibitors 失效
标题翻译：三环6-亚烷基 - 青霉烯作为β-内酰胺酶抑制剂

公开(公告)号：US07018997B2

公开(公告)日：2006-03-28

申请号：US10427427

申请日：2003-05-01

申请人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Ado Mihira , Atul Agarwal , Hideki Ushirogochi , Yansong Gu , Satoshi Tamai , Fuk-Wah Sum

发明人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Ado Mihira , Atul Agarwal , Hideki Ushirogochi , Yansong Gu , Satoshi Tamai , Fuk-Wah Sum

IPC分类号： C07D499/881 , C07D519/06 , A61K31/43 , A61K31/431 , A61P31/04

CPC分类号： C07D519/00

摘要： The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is S.

摘要翻译： 本发明提供式I化合物，药物组合物及其在有需要的患者中治疗细菌感染或疾病的用途。其中A和B之一表示氢，另一个表示任选取代的稠合三环杂芳基; 而X是S.

5.

发明授权
Tricyclic 6-alkylidene-penems as β-lactamase inhibitors 失效
标题翻译：三环6-亚烷基 - 半乳糖和β-内酰胺酶抑制剂

公开(公告)号：US07691842B2

公开(公告)日：2010-04-06

申请号：US12187707

申请日：2008-08-07

申请人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Ado Mihira , Atul Agarwal , Hideki Ushirogochi , Yansong Gu , Satoshi Tamai , Fuk-Wah Sum

发明人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Ado Mihira , Atul Agarwal , Hideki Ushirogochi , Yansong Gu , Satoshi Tamai , Fuk-Wah Sum

IPC分类号： C07D503/10 , C07D519/06 , A61P31/04 , A61K31/424 , A61K31/43 , A61K31/431 , C07D499/881

CPC分类号： C07D519/00

摘要： The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof, wherein one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is O.

摘要翻译： 本发明提供式I化合物，药物组合物及其在有需要的患者中治疗细菌感染或疾病的用途，其中A和B之一表示氢，另一个为任选取代的稠合三环杂芳基; 而X是O.

6.

发明申请
Tricyclic 6-Alkylidene-Penems as Beta-Lactamase Inhibitors 失效
标题翻译：作为β-内酰胺酶抑制剂的三环6-亚烷基 - 半乳糖

公开(公告)号：US20080318921A1

公开(公告)日：2008-12-25

申请号：US12187707

申请日：2008-08-07

申请人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Ado Mihira , Atul Agarwal , Hideki Ushirogochi , Yansong Gu , Satoshi Tamai , Fuk-Wah Sum

发明人： Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Takao Abe , Ado Mihira , Atul Agarwal , Hideki Ushirogochi , Yansong Gu , Satoshi Tamai , Fuk-Wah Sum

IPC分类号： C07D503/10 , A61K31/424

CPC分类号： C07D519/00

摘要： The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.

摘要翻译： 本发明提供式I化合物，药物组合物及其在有需要的患者中治疗细菌感染或疾病的用途。

7.

发明授权
Triazine compounds as PI3 kinase and mTOR inhibitors 有权
标题翻译：三嗪化合物作为PI3激酶和mTOR抑制剂

公开(公告)号：US08445486B2

公开(公告)日：2013-05-21

申请号：US13490309

申请日：2012-06-06

申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi

发明人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi

IPC分类号： A61K31/535 , C07D413/14

CPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08

摘要： Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.

摘要翻译： 式I的化合物，其中：R1是和R2，R4和R6-9在本文中定义，及其药学上可接受的盐和酯。这些化合物抑制PI3激酶和mTOR，并可用于治疗PI3激酶和mTOR介导的疾病，如多种癌症。公开了制备和使用本发明化合物的方法。还公开了含有本发明化合物的各种组合物。

8.

发明授权
Triazine compounds as PI3 kinase and mTOR inhibitors 有权
标题翻译：三嗪化合物作为PI3激酶和mTOR抑制剂

公开(公告)号：US08217036B2

公开(公告)日：2012-07-10

申请号：US13218571

申请日：2011-08-26

申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi

发明人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi

IPC分类号： A61K31/535 , C07D413/14

CPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08

摘要： Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.

摘要翻译： 式I的化合物，其中：R1是和R2，R4和R6-9在本文中定义，及其药学上可接受的盐和酯。这些化合物抑制PI3激酶和mTOR，并可用于治疗PI3激酶和mTOR介导的疾病，如多种癌症。公开了制备和使用本发明化合物的方法。还公开了含有本发明化合物的各种组合物。