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17 条记录 (耗时 0.04 秒)

    PIPERIDINYL INDOLE AND TETROHYDROPYRIDINYL INDOLE DERIVATIVES AND METHODS OF THEIR USE
    2.
    发明申请
    PIPERIDINYL INDOLE AND TETROHYDROPYRIDINYL INDOLE DERIVATIVES AND METHODS OF THEIR USE 审中-公开
    哌啶吲哚和四氢吡啶并吲哚衍生物及其使用方法

    公开(公告)号：US20070225319A1

    公开(公告)日：2007-09-27

    申请号：US11750428

    申请日：2007-05-18

    申请人： Aranapakam Venkatesan ,  Osvaldo Santos ,  Yansong Gu

    发明人： Aranapakam Venkatesan ,  Osvaldo Santos ,  Yansong Gu

    IPC分类号： A61K31/437 ,  A61K31/445 ,  C07D401/02 ,  C07D487/02

    CPC分类号： C07D405/14 ,  C07D409/14 ,  C07D471/04

    摘要： 3-Piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed. Methods of using the derivatives and compositions containing the derivatives in the prevention and/or treatment of serotonin disorders, such as depression and anxiety, are also disclosed. Additionally, processes for the preparation of 3-piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed.

    摘要翻译： 3-哌啶-4-基-1H-吲哚和3-（1,2,3,6-四氢 - 吡啶-4-基）-1H-吲哚衍生物。 还公开了使用含有衍生物的衍生物和组合物在预防和/或治疗5-羟色胺病症例如抑郁和焦虑中的方法。 另外，公开了制备3-哌啶-4-基-1H-吲哚和3-（1,2,3,6-四氢 - 吡啶-4-基）-1H-吲哚衍生物的方法。

    Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans
    4.
    发明申请
    Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans 审中-公开
    杂环稠合苯并二恶烷的抗抑郁芳基哌嗪衍生物

    公开(公告)号：US20060276481A1

    公开(公告)日：2006-12-07

    申请号：US11505663

    申请日：2006-08-16

    申请人： Deborah Evrard ,  Dahui Zhou ,  Gary Stack ,  Aranapakam Venkatesan ,  Amedeo Failli ,  Susan Croce

    发明人： Deborah Evrard ,  Dahui Zhou ,  Gary Stack ,  Aranapakam Venkatesan ,  Amedeo Failli ,  Susan Croce

    IPC分类号： A61K31/496 ,  C07D491/02

    CPC分类号： C07D491/04 ,  Y02P20/582

    摘要： Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

    摘要翻译： 式I化合物可用于治疗抑郁症（包括但不限于重度抑郁症，儿童抑郁症和抑郁症），焦虑症，恐慌症，创伤后应激障碍，经前期焦虑症（也称为月经前） 综合征），注意缺陷障碍（伴有和不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关 疾病

    Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors
    8.
    发明申请
    Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors 审中-公开
    双环6-亚烷基 - 半乳糖作为D类β-内酰胺酶抑制剂

    公开(公告)号：US20060276445A1

    公开(公告)日：2006-12-07

    申请号：US11444344

    申请日：2006-05-31

    申请人： Tarek Mansour ,  Aranapakam Venkatesan

    发明人： Tarek Mansour ,  Aranapakam Venkatesan

    IPC分类号： A61K31/43 ,  A61K31/424

    CPC分类号： A61K31/43 ,  A61K31/424 ,  A61K31/429 ,  A61K2300/00

    摘要： This invention relates to certain bicyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with β-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of general formula I or a pharmaceutically acceptable salt or in vivo hydrolyzable ester R5 thereof: wherein: One of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X═O or S.

    摘要翻译： 本发明涉及作为D类酶抑制剂的某些二环-6-亚烷基半胱氨酸。 β-内酰胺酶水解β-内酰胺抗生素，因此成为细菌耐药的主要原因。 当与β-内酰胺抗生素组合时，本发明的化合物将提供有效治疗以防止威胁生命的细菌感染。 根据本发明，提供通式I的化合物或其药学上可接受的盐或体内可水解的酯R 5：其中：A和B中的一个表示氢，另一个是任选取代的 稠合双环杂芳基; 和X-O或S.