公开(公告)号：US09895448B2

公开(公告)日：2018-02-20

申请号：US15133010

申请日：2016-04-19

Applicant: Arbutus Biopharma Corporation

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  David Butler ,  Muthusamy Jayaraman

IPC: A61K47/48 ,  C12N15/113 ,  A61K48/00 ,  C12N15/11 ,  C12N15/87 ,  A61K47/54 ,  A61K47/55

CPC classification number: A61K47/554 ,  A61K47/545 ,  A61K47/549 ,  A61K47/551 ,  A61K48/0008 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/87 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3513 ,  C12N2320/32 ,  C12Y304/21021

Abstract: The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.

公开(公告)号：US09764036B2

公开(公告)日：2017-09-19

申请号：US14953677

申请日：2015-11-30

Applicant: ARBUTUS BIOPHARMA CORPORATION

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  David Butler ,  Jayaprakash K. Nair ,  Muthusamy Jayaraman ,  Laxman Eltepu

IPC: A61K47/44 ,  C07D491/113 ,  C07D317/72 ,  C07D317/46 ,  C07D405/12 ,  A61K31/7088 ,  C07D491/056 ,  C07D317/44 ,  C07D317/28 ,  A61K31/713

CPC classification number: A61K47/44 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/713 ,  A61K39/00 ,  A61K39/39 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/28 ,  A61K2039/55555 ,  A61K2039/55561 ,  C07C229/08 ,  C07C229/30 ,  C07C237/16 ,  C07C251/38 ,  C07C251/78 ,  C07C271/12 ,  C07C271/20 ,  C07C323/25 ,  C07D203/10 ,  C07D317/28 ,  C07D317/44 ,  C07D317/46 ,  C07D317/72 ,  C07D319/06 ,  C07D405/12 ,  C07D491/056 ,  C07D491/113 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32 ,  Y02A50/464

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures:

公开(公告)号：US10456473B2

公开(公告)日：2019-10-29

申请号：US15594244

申请日：2017-05-12

Applicant: Arbutus Biopharma Corporation

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Michael E. Jung

IPC: A61K47/22 ,  A61K9/127 ,  C07D295/13 ,  C12N15/113

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).

公开(公告)号：US20180369384A1

公开(公告)日：2018-12-27

申请号：US15596845

申请日：2017-05-16

Applicant: Arbutus Biopharma Corporation

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Mamta Kapoor ,  Rajesh Kumar Kainthan

IPC: A61K47/18 ,  C12N15/88 ,  C07D491/10 ,  C07D317/72 ,  C07D317/44 ,  C07D317/28 ,  C07C323/25 ,  C07C271/20 ,  C07C271/12 ,  C07C251/40 ,  C07C229/12 ,  C07C219/08 ,  C07C217/08 ,  A61K47/22 ,  A61K31/713 ,  A61K31/7105

Abstract: The present invention is based, in part, upon the discovery of charged lipids that provide advantages when used in lipid particles for the in vivo delivery of a therapeutic agent. As such, described herein are compounds useful for delivering a nucleic acid to a cell.

公开(公告)号：US20180221494A1

公开(公告)日：2018-08-09

申请号：US15837785

申请日：2017-12-11

Applicant: Arbutus Biopharma Corporation

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  David Butler ,  Muthusamy Jayaraman

IPC: A61K47/54 ,  A61K47/55 ,  A61K48/00 ,  C12N15/11 ,  C12N15/113 ,  C12N15/87

CPC classification number: A61K47/554 ,  A61K47/545 ,  A61K47/549 ,  A61K47/551 ,  A61K48/0008 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/87 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3513 ,  C12N2320/32 ,  C12Y304/21021

Abstract: The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.

公开(公告)号：US20180104342A1

公开(公告)日：2018-04-19

申请号：US15594244

申请日：2017-05-12

Applicant: Arbutus Biopharma Corporation

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Michael E. Jung

IPC: A61K47/22 ,  C12N15/113 ,  A61K9/127 ,  C07D295/13

CPC classification number: A61K47/22 ,  A61K9/1272 ,  C07D295/13 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  Y02A50/463

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).

公开(公告)号：US20180064807A1

公开(公告)日：2018-03-08

申请号：US15474911

申请日：2017-03-30

Applicant: Arbutus Biopharma Corporation

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  David Butler ,  Jayaprakash K. Nair ,  Muthusamy Jayaraman ,  Laxman Eltepu

IPC: A61K39/39 ,  C12N15/113 ,  A61K9/127 ,  C07D203/10 ,  C07D317/28 ,  C07D319/06 ,  A61K31/713 ,  C07C229/08 ,  C07C251/38 ,  A61K47/18 ,  A61K47/20 ,  A61K47/28 ,  C07C237/16 ,  C07C323/25 ,  C07C251/78 ,  C07C271/12 ,  C07C271/20 ,  A61K47/10 ,  C12N15/11

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure:

公开(公告)号：US12023383B2

公开(公告)日：2024-07-02

申请号：US18110654

申请日：2023-02-16

Applicant: ARBUTUS BIOPHARMA CORPORATION

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Michael E. Jung

IPC: A61K47/22 ,  A61K9/127 ,  C07D295/13 ,  C12N15/113

CPC classification number: A61K47/22 ,  A61K9/1272 ,  C07D295/13 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  Y02A50/30

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I).

公开(公告)号：US20240066129A1

公开(公告)日：2024-02-29

申请号：US18110654

申请日：2023-02-16

Applicant: ARBUTUS BIOPHARMA CORPORATION

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Michael E. Jung

IPC: A61K47/22 ,  A61K9/127 ,  C07D295/13 ,  C12N15/113

CPC classification number: A61K47/22 ,  A61K9/1272 ,  C07D295/13 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  Y02A50/30

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I).

公开(公告)号：US10953095B2

公开(公告)日：2021-03-23

申请号：US16593661

申请日：2019-10-04

Applicant: Arbutus Biopharma Corporation

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Michael E. Jung

IPC: A61K47/22 ,  A61K9/127 ,  C07D295/13 ,  C12N15/113

Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).