公开(公告)号：US11759515B2

公开(公告)日：2023-09-19

申请号：US17196890

申请日：2021-03-09

Applicant: Arcturus Therapeutics, Inc.

Inventor： Sean Michael Sullivan ,  Daiki Matsuda ,  Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Priya Prakash Karmali ,  Jared Henry Davis ,  Yanjie Bao

IPC: A61K39/215 ,  C07K14/005 ,  C12N15/86 ,  A61K47/20 ,  A61K47/26 ,  A61K47/10 ,  A61K9/51 ,  A61K39/12 ,  C07K14/18 ,  C12N7/00 ,  A61K39/00 ,  A61K38/00

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61K39/12 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  C07K14/005 ,  C07K14/1808 ,  C12N7/00 ,  C12N15/86 ,  A61K38/00 ,  A61K2039/53 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2830/42 ,  C12N2830/50

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

公开(公告)号：US11744887B2

公开(公告)日：2023-09-05

申请号：US17196889

申请日：2021-03-09

Applicant: Arcturus Therapeutics, Inc.

Inventor： Sean Michael Sullivan ,  Daiki Matsuda ,  Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Priya Prakash Karmali ,  Jared Henry Davis ,  Yanjie Bao ,  Amit Sagi

IPC: A61K39/215 ,  C07K14/005 ,  C12N15/86 ,  A61K47/20 ,  A61K47/26 ,  A61K47/10 ,  A61K9/51 ,  A61K39/12 ,  C07K14/18 ,  C12N7/00 ,  A61K39/00 ,  A61K38/00

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61K39/12 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  C07K14/005 ,  C07K14/1808 ,  C12N7/00 ,  C12N15/86 ,  A61K38/00 ,  A61K2039/53 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2830/42 ,  C12N2830/50

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

公开(公告)号：US12220455B2

公开(公告)日：2025-02-11

申请号：US18345893

申请日：2023-06-30

Applicant: Arcturus Therapeutics, Inc.

Inventor： Sean Michael Sullivan ,  Daiki Matsuda ,  Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Priya Prakash Karmali ,  Jared Henry Davis ,  Yanjie Bao ,  Amit Sagi

IPC: A61K39/215 ,  A61K9/51 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  C07K14/005 ,  C07K14/18 ,  C12N7/00 ,  C12N15/86

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

公开(公告)号：US20230219996A1

公开(公告)日：2023-07-13

申请号：US17816243

申请日：2022-07-29

Applicant: Arcturus Therapeutics, Inc.

Inventor： Daiki MATSUDA ,  Sean Michael Sullivan ,  Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Priya Prakash Karmali ,  Yanjie Bao ,  Amit Sagi ,  Rajesh Mukthavaram

IPC: C07H21/02 ,  C07K14/18 ,  C07K14/165 ,  C07K14/11 ,  A61K9/127 ,  A61K47/14 ,  A61K47/28 ,  A61K9/19

CPC classification number: C07H21/02 ,  A61K9/19 ,  A61K9/127 ,  A61K47/14 ,  A61K47/28 ,  C07K14/11 ,  C07K14/165 ,  C07K14/1808

Abstract: Provided herein are RNA molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include RNA molecules encoding viral replication proteins and antigenic proteins or fragments thereof, and lipids. RNA molecules and compositions including them are useful for inducing immune responses.